メロミオシン
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2019/06/23 06:10:09」(JST)
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Meromyosin is a part of myosin (mero meaning "part of"). With regards to human anatomy myosin and actin constitute the basic functional unit of a muscle fiber, called sarcomere, playing a role in muscle contraction.
Biochemically viewed meromyosin form subunits of the actin-associated motor protein, myosin, which is formed by trypsin proteolysis (protein breakdown).[citation needed] Following proteolysis, two types of meromyosin are formed: heavy meromyosin (HMM) and light meromyosin (LMM).
Light meromyosin has a long, straight portion in the “tail” region. Heavy meromyosin is a protein chain terminating in a globular head portion/cross bridge. HMM consists of two subunits, Heavy Meromyosin Subunit 1 and 2 (HMMS-1 and HMMS-2). The majority of myosin activity is concentrated in HMMS-1. HMMS-1 has an actin binding site and ATP binding site (myosin ATPase) that determines the rate of muscle contraction when muscle is stretched.
Light and heavy meromyosin are subunits of myosin filaments (thick myofilaments).
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English Journal
- Unidirectional growth of heavy meromyosin (HMM) clusters along actin filaments revealed by real-time fluorescence microscopy.
- Hirakawa R1, Nishikawa Y1, Uyeda TQP2, Tokuraku K1.
- Cytoskeleton (Hoboken, N.J.).Cytoskeleton (Hoboken).2017 Sep 9. doi: 10.1002/cm.21408. [Epub ahead of print]
- PMID 28888060
- Lessons from a tarantula: new insights into myosin interacting-heads motif evolution and its implications on disease.
- Alamo L1, Pinto A1, Sulbarán G1,2, Mavárez J3, Padrón R4.
- Biophysical reviews.Biophys Rev.2017 Sep 4. doi: 10.1007/s12551-017-0292-4. [Epub ahead of print]
- PMID 28871552
- Acceleration of the sliding movement of actin filaments with the use of a non-motile mutant myosin in in vitro motility assays driven by skeletal muscle heavy meromyosin.
- Iwase K1, Tanaka M1, Hirose K2, Uyeda TQP2, Honda H1.
- PloS one.PLoS One.2017 Jul 24;12(7):e0181171. doi: 10.1371/journal.pone.0181171. eCollection 2017.
- PMID 28742155
Japanese Journal
- 1P152 コフィリンの結合を協同的に阻害するG146Vアクチンミュータントへのヘビーメロミオシンの結合(筋肉(筋蛋白質・収縮),第48回日本生物物理学会年会)
- Identification of the glutamine residue that may be involved in the transglutaminase-mediated intramolecular crosslinking of carp and walleye pollack myosin
- Asymmetric Photocross-Linking of Singly Phosphorylated Smooth Muscle Heavy Meromyosin
Related Links
- In biochemistry, meromyosin (mero meaning "part of") are subunits of the actin- associated motor protein, myosin, formed by trypsin digestion (proteolysis). Following digestion, two types of meromyosin are formed: heavy meromyosin ( HMM) ...
- Heavy meromyosin (HMM) is the larger of the two fragments obtained from the muscle protein myosin II following limited proteolysis by trypsin or chymotrypsin. HMM is used to determine the polarity of actin filaments by decorating them with ...
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