English Journal

STAT3 and importins are novel mediators of early molecular and cellular responses in experimental duodenal ulceration.

Khomenko T1, Deng X, Ahluwalia A, Tarnawski A, Patel KN, Sandor Z, Szabo S.
Digestive diseases and sciences.Dig Dis Sci.2014 Feb;59(2):297-306. doi: 10.1007/s10620-013-2807-6. Epub 2014 Jan 3.
OBJECTIVES: Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that directly upregulates VEGF, Ref-1, p21, and anti-apoptotic genes such as Bcl-xL. In this study, we hypothesized that STAT3 signaling is activated and provides a critical protective role that is requi
PMID 24385009

Discovery of lansoprazole and its unique pharmacological properties independent from anti-secretory activity.

Satoh H.
Current pharmaceutical design.Curr Pharm Des.2013;19(1):67-75.
The proton pump inhibitors (PPIs) lansoprazole (LPZ) and omeprazole (OPZ) have been widely used for more than 20 years in the treatment of acid-related diseases such as gastro-duodenal ulcers and reflux esophagitis. Both LPZ and OPZ are derivatives of 2-[(2- pyridylmethyl)sulfinyl]-1H-benzimidazole,
PMID 22950496

Chemical screen identifies FDA-approved drugs and target pathways that induce precocious pancreatic endocrine differentiation.

Rovira M1, Huang W, Yusuff S, Shim JS, Ferrante AA, Liu JO, Parsons MJ.
Proceedings of the National Academy of Sciences of the United States of America.Proc Natl Acad Sci U S A.2011 Nov 29;108(48):19264-9. doi: 10.1073/pnas.1113081108. Epub 2011 Nov 14.
Pancreatic β-cells are an essential source of insulin and their destruction because of autoimmunity causes type I diabetes. We conducted a chemical screen to identify compounds that would induce the differentiation of insulin-producing β-cells in vivo. To do this screen, we brought together the us
PMID 22084084