WordNet
- inflammation of the brain and spinal cord and their meninges (同)cerebromeningitis, encephalomeningitis
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/09/03 06:55:35」(JST)
[Wiki en表示]
Meningoencephalitis |
Classification and external resources |
Specialty |
neurology |
ICD-10 |
G04 |
ICD-9-CM |
323.9 |
DiseasesDB |
22354 |
MeSH |
D888590 |
Meningoencephalitis (; from Greek: meninges- membranes; enkephalos brain; and -itis inflammation) is a medical condition that simultaneously resembles both meningitis, which is an infection or inflammation of the meninges, and encephalitis, which is an infection or inflammation of the brain.
Contents
- 1 Causes
- 1.1 Bacterial
- 1.2 Viral
- 1.3 Other/multiple
- 1.4 Protozoal
- 1.5 Animal
- 2 Prognosis
- 3 Notable cases
- 4 In popular culture
- 5 See also
- 6 References
Causes
Causative organisms include protozoans, viral and bacterial pathogens.
Specific types include:
Bacterial
- Listeria monocytogenes
- Neisseria meningitidis
- Rickettsia prowazekii
- Mycoplasma pneumoniae
- Tuberculosis
- Borrelia (Lyme disease)
- Leptospirosis
Viral
- Tick-borne meningoencephalitis
- West Nile virus
- Measles
- Epstein-Barr virus
- Varicella-zoster virus
- Enterovirus
- Herpes simplex virus type 1
- Herpes simplex virus type 2
- Mumps, a relatively common cause of meningoencephalitis. However, most cases are mild, and mumps meningoencephalitis generally does not result in death or neurologic sequelae.[1]
- HIV, a very small number of individuals exhibit meningoencephalitis at the primary stage of infection.[2][3]
Other/multiple
- Granulomatous meningoencephalitis
- Antibodies targeting amyloid beta peptide proteins which have been used during research on Alzheimer's disease.[4]
- The fungus, Cryptococcus neoformans, can be symptomatically manifested within the CNS as meningoencephalitis with hydrocephalus being a very characteristic finding due to the unique thick polysaccharide capsule of the organism.
- Anti-N-methyl-D-aspartate (anti-NMDA) receptor antibodies, which are also associated with seizures and a movement disorder
- Vasculitis
Protozoal
- Primary amoebic meningoencephalitis, e.g., Naegleria fowleri, Balamuthia mandrillaris, Sappinia diploidea
- Trypanosoma brucei
- Toxoplasma gondii (sporozoa)
Ameobic pathogens exist as free-living protozoans. Nevertheless, these pathogens cause rare and uncommon CNS infections. N. fowleri produces primary amebic meningoencephalitis (PAM). The symptoms of PAM are indistinguishable from acute bacterial meningitis. Other amebae cause granulomatous amebic encephalitis (GAE), which is a more subacute and can even a non-symptomatic chronic infection. Ameobic meningoencephalitis can mimic a brain abscess, aseptic or chronic meningitis, or CNS malignancy.[5]
Animal
- Halicephalobus gingivalis
Animal pathogens exist as facultative parasites. They are an exceptionally rare cause of meningoencephalitis.[6]
Prognosis
The disease is associated with high rates of mortality and severe morbidity.[citation needed]
Notable cases
It was cause of death of the popular British TV presenter Christopher Price.[7]
In May, 2009 former Premier of New South Wales (Australia) Morris Iemma was admitted to hospital with meningoencephalitis.[8]
Recent medical research indicates that it was the cause of Mary Ingalls' (older sister of Laura Ingalls) blindness (not scarlet fever as the book indicates).[9][10][11][12]
In popular culture
In the 2011 film Contagion, the pandemic disease kills when it causes meningoencephalitis in patients. The film's virus is named Meningoencephalitis Virus One (MEV-1).
In the 'House' episode Euphoria (Part 2), primary amoebic meningoencephalitis was the cause of Foreman's symptoms.
See also
- Meningitis
- Meningism
- Primary amoebic meningoencephalitis
- Encephalitis
References
- ^ Bruyn HB, Sexton HM, Brainerd HD (March 1957). "Mumps meningoencephalitis; a clinical review of 119 cases with one death". Calif Med 86 (3): 153–60. PMC 1512024. PMID 13404512.
- ^ Newton, PJ; Newsholme, W; Brink, NS; Manji, H; Williams, IG; Miller, RF (2002). "Acute meningoencephalitis and meningitis due to primary HIV infection". BMJ (Clinical research ed.) 325 (7374): 1225–7. doi:10.1136/bmj.325.7374.1225. PMC 1124692. PMID 12446542.
- ^ Del Saz, SV; Sued, O; Falcó, V; Agüero, F; Crespo, M; Pumarola, T; Curran, A; Gatell, JM et al. (2008). "Acute meningoencephalitis due to human immunodeficiency virus type 1 infection in 13 patients: clinical description and follow-up". Journal of neurovirology 14 (6): 474–9. doi:10.1080/13550280802195367. PMID 19037815.
- ^ Orgogozo JM, Gilman S, Dartigues JF et al. (2003-07-08). "Subacute meningoencephalitis in a subset of patients with AD after Aß42 immunization". Neurology 61 (1): 46–54. doi:10.1212/01.WNL.0000073623.84147.A8. PMID 12847155. Retrieved 2008-05-01.
- ^ Amebic Meningoencephalitis at eMedicine
- ^ "Rare parasitic worm kills two kidney donor patients, inquest hears". The Guardian. 2014-11-18. Retrieved 2014-11-24.
- ^ "Presenter Killed by Rare Infection". BBC News. 2002-06-19. Retrieved 2008-05-01.
- ^ Silmalis, Linda (2009-06-28). "Paralysed Iemma fights to walk again". The Sunday Telegraph. Retrieved 2009-06-28.
- ^ Allexan, Sarah S.; Byington, Carrie L.; Finkelstein, Jerome I.; Tarini, Beth A. (2013). "Blindness in Walnut Grove: How Did Mary Ingalls Lose Her Sight?". Pediatrics. peds.2012-1438.
- ^ Dell'Antonia, KJ (2013-02-04). "Scarlet Fever Probably Didn’t Blind Mary Ingalls". New York Times. Retrieved 2013-02-04.
- ^ Serena, Gordon (2013-02-04). "Mistaken Infection 'On The Prairie'?". U.S. News and World Report. Retrieved 2013-02-04.
- ^ "What really made Mary Ingalls go blind?". NBC News. 2013-02-04.
Inflammation
|
|
Acute |
Plasma derived mediators |
- Bradykinin
- complement
- coagulation
- Factor XII
- Plasmin
- Thrombin
|
|
Cell derived mediators |
preformed: |
- Lysosome granules
- biogenic amines
|
|
synthesized on demand: |
- cytokines
- eicosanoids
- Leukotriene B4
- Prostaglandins
- Nitric oxide
- Kinins
|
|
|
|
Chronic |
- Macrophage
- Epithelioid cell
- Giant cell
- Granuloma
|
|
Processes |
Traditional: |
- Rubor
- Calor
- Tumor
- Dolor (pain)
- Functio laesa
|
|
Modern: |
- Acute-phase reaction/Fever
- Vasodilation
- Increased vascular permeability
- Exudate
- Leukocyte extravasation
- Chemotaxis
|
|
|
Specific locations |
|
|
Meningitis and other diseases of meninges (G00–G03, 320–322)
|
|
Meningitis |
- Arachnoiditis
- Bacterial
- Tuberculous
- Haemophilus
- Pneumococcal
- Viral
- Fungal
- Aseptic
|
|
Other |
|
|
Index of the central nervous system
|
|
Description |
- Anatomy
- meninges
- cortex
- association fibers
- commissural fibers
- lateral ventricles
- basal ganglia
- diencephalon
- mesencephalon
- pons
- cerebellum
- medulla
- spinal cord
- Physiology
- Development
|
|
Disease |
- Cerebral palsy
- Meningitis
- Demyelinating diseases
- Seizures and epilepsy
- Headache
- Stroke
- Sleep
- Congenital
- Injury
- Neoplasms and cancer
- Other
- Symptoms and signs
- head and neck
- eponymous
- lesions
- Tests
|
|
Treatment |
- Procedures
- Drugs
- general anesthetics
- analgesics
- addiction
- epilepsy
- cholinergics
- migraine
- Parkinson's
- vertigo
- other
|
|
|
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
English Journal
- Acute meningoencephalitis associated with echovirus 9 infection in Sri Lanka, 2009.
- Danthanarayana N1,2, Williams DT3,4, Williams SH3, Thevanesam V5, Speers DJ3,6, Fernando MS7.
- Journal of medical virology.J Med Virol.2015 Dec;87(12):2033-9. doi: 10.1002/jmv.24267. Epub 2015 May 21.
- The aetiology of acute meningoencephalitis in Sri Lankan children and adults is poorly understood. This study was carried out to determine pathogens responsible for meningoencephalitis in Sri Lanka. A hospital-based cross-sectional study was performed using cerebrospinal fluid samples (22 adult and
- PMID 25983131
- Naegleria fowleri: Pathogenesis, Diagnosis, and Treatment Options.
- Grace E1, Asbill S1, Virga K2.
- Antimicrobial agents and chemotherapy.Antimicrob Agents Chemother.2015 Nov;59(11):6677-81. doi: 10.1128/AAC.01293-15. Epub 2015 Aug 10.
- Naegleria fowleri has generated tremendous media attention over the last 5 years due to several high-profile cases. Several of these cases were followed very closely by the general public. N. fowleri is a eukaryotic, free-living amoeba belonging to the phylum Percolozoa. Naegleria amoebae are ubiqui
- PMID 26259797
- Simian Virus 40 Infection in the Spinal Cord of Simian Immunodeficiency Virus-Immunosuppressed Rhesus Macaques.
- Kaliyaperumal S1, Wüthrich C, Westmoreland SV, Koralnik IJ.
- Journal of neuropathology and experimental neurology.J Neuropathol Exp Neurol.2015 Nov;74(11):1071-6. doi: 10.1097/NEN.0000000000000252.
- Progressive multifocal leukoencephalopathy (PML) is an often-fatal demyelinating disease of the CNS that usually develops in immunocompromised individuals because of reactivation of quiescent JC virus (JCV). There are only a few reports of JCV infection in the human spinal cord. Progressive multifoc
- PMID 26469249
Japanese Journal
- 遅発性増悪を来した健常者発症のクリプトコッカス髄膜脳炎の1例
- 沼畑 恭子,赤岩 靖久,吉澤 健太,乗峯 苑子,尾上 祐行,宮本 智之
- 臨床神経学 59(4), 190-194, 2019
- <p>症例は29歳男性,生来健康.頭痛と発熱が増悪し当院搬送.体温38.3°C,項部硬直著明,脳脊髄液検査で初圧500 mmH<sub>2</sub>O,細胞数増加,髄液糖/血糖比0.027,クリプトコッカス抗原陽性からクリプトコッカス髄膜脳炎と診断し抗真菌薬治療で症状改善を認めていた.第18病日に全身痙攣,右視野暗点を認め,頭部MRIで両側大脳皮質に散在性の病 …
- NAID 130007636895
- 遅発性増悪を来した健常者発症のクリプトコッカス髄膜脳炎の1例
- 沼畑 恭子,赤岩 靖久,吉澤 健太,乗峯 苑子,尾上 祐行,宮本 智之
- 臨床神経学, 2019
- <p>症例は29歳男性,生来健康.頭痛と発熱が増悪し当院搬送.体温38.3°C,項部硬直著明,脳脊髄液検査で初圧500 mmH<sub>2</sub>O,細胞数増加,髄液糖/血糖比0.027,クリプトコッカス抗原陽性からクリプトコッカス髄膜脳炎と診断し抗真菌薬治療で症状改善を認めていた.第18病日に全身痙攣,右視野暗点を認め,頭部MRIで両側大脳皮質に散在性の病 …
- NAID 130007628027
- Meningoencephalitis Caused by a <i>Campylobacter fetus</i> in a Patient with Chronic Alcoholism
- Tanabe Sho,Kutsuna Satoshi,Tsuboi Motoyuki,Takeshita Nozomi,Hayakawa Kayoko,Ohmagari Norio
- Internal Medicine, 2019
- … meningoencephalitis in a patient with chronic alcoholism. … meningoencephalitis. … meningoencephalitis, should be considered. …
- NAID 130007626569
Related Pictures
★リンクテーブル★
[★]
リステリア髄膜脳炎
- 関
- Listeria meningitis、Listeria monocytogenes meningitis
[★]
急性流行性白質脳炎。急性原発性出血性髄膜脳炎
[★]
自由生活性アメーバ性髄膜脳炎
[★]
眼球クローヌス髄膜脳炎