WordNet

a harmful or corrupting agency; "bigotry is a virus that must not be allowed to spread"; "the virus of jealousy is latent in everyone"
(virology) ultramicroscopic infectious agent that replicates itself only within cells of living hosts; many are pathogenic; a piece of nucleic acid (DNA or RNA) wrapped in a thin coat of protein
a software program capable of reproducing itself and usually capable of causing great harm to files or other programs on the same computer; "a true virus cannot spread to another computer without human assistance" (同)computer virus

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ビールス,ろ過性病原体
manの複数形

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/07/23 22:37:40」(JST)

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Mengovirus, also known as Columbia SK virus, mouse Elberfield virus and Encephalomyocarditisvirus (EMCV), belongs to the genus Cardiovirus which is a member of the Picornaviridae. Its genome is a single stranded positive-sense RNA molecule, making the Mengoviruses a class IV virus under the Baltimore classification system. The genome is approximately 8400nt in length, and has 5’ VG protein (Virus genome protein) and a 3’ polyadenine tail.

Structure

The Mengovirus is a non-enveloped virus which has a nucleocapsid made up of 12 subunits. The virion is 30 nm in diameter and displays icosohedral symmetry.

Gene Expression and Genome Replication

Once inside a host cell, the Mengovirus genome acts as a piece of mRNA, and is directly translated by host ribosomes in the cytoplasm. There is a large un-translated region at the 5’ end of the RNA that has a ribosome binding site, removing the need of a cap. A single polypeptide is made, and is cleaved into individual proteins by viral proteases. The genome is divided into three parts: P1, P2 and P3. P1 encodes the virus capsid proteins, P2 and P3 encode genes required for genome replication to occur. For replication to occur an intermediate double stranded RNA molecule is made to be used as a template for the production of positive sense genomes.

Infection

Mengovirus is infectious to vertebrate animals, and has been isolated from mice and other rodents. It can also cause acute fever in humans. There is no specific treatment for a Mengovirus infection; although Persantine has been shown to inhibit its replication.^[1] The illness is not severe enough to require vaccination. The Mengovirus is able to suppress the host’s immune response by reducing the expression of Nuclear Factor kappa B using the 5’ un-translated region.

References

^ http://jvi.asm.org/cgi/content/full/79/17/11062?view=long&pmid=16103157

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English Journal

Sixty Years of Discovery.

, B B, D D, D D, .
Annual review of immunology. 2019 Apr;37()1-17.
Each of us is a story. Mine is a story of doing science for 60 years, and I am honored to be asked to tell it. Even though this autobiography was written for the , I have chosen to describe my whole career in science because the segment that was immunology is so intertwined with all else I was doing
PMID 30379594

Extended direct lysis method for virus detection on berries including droplet digital RT-PCR or real time RT-PCR with reduced influence from inhibitors.

Sun B, Bosch A, Myrmel M.
Journal of virological methods. 2019 Apr;().
Detection of viruses on berries is a challenging task, often hampered by the presence of RT-qPCR inhibiting substances from berry juice. A direct extraction method for virus detection (murine norovirus and GA phage) on frozen raspberries was previously published. We expanded (different types of berr
PMID 30953663

Bacterial Stabilization of a Panel of Picornaviruses.

Aguilera ER, Nguyen Y, Sasaki J, Pfeiffer JK.
mSphere. 2019 04;4(2).
Several viruses encounter various bacterial species within the host and in the environment. Despite these close encounters, the effects of bacteria on picornaviruses are not completely understood. Previous work determined that poliovirus (PV), an enteric virus, has enhanced virion stability when exp
PMID 30944213