melancholia

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depressiondepressive disorderdepressive illnessdepressive neurosisdepressive syndromeendogenous depressionunipolar depression
Depression; Major depression


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「extreme depression characterized by tearful sadness and irrational fears」

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「憂うつ病,うつ病」

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/07/01 06:15:18」(JST)

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英文文献

  • A Double-blind, randomized, placebo-controlled clinical trial of S-adenosyl-L-methionine (SAMe) versus escitalopram in major depressive disorder.
  • Mischoulon D, Price LH, Carpenter LL, Tyrka AR, Papakostas GI, Baer L, Dording CM, Clain AJ, Durham K, Walker R, Ludington E, Fava M.Author information 1 Bowdoin Sq, 6th Floor, Massachusetts General Hospital, Boston, MA 02114 dmischoulon@partners.org.AbstractOBJECTIVE: To examine the comparative antidepressant efficacy of S-adenosyl-l-methionine (SAMe) and escitalopram in a placebo-controlled, randomized, double-blind clinical trial.
  • The Journal of clinical psychiatry.J Clin Psychiatry.2014 Dec 24. [Epub ahead of print]
  • OBJECTIVE: To examine the comparative antidepressant efficacy of S-adenosyl-l-methionine (SAMe) and escitalopram in a placebo-controlled, randomized, double-blind clinical trial.METHOD: One hundred eighty-nine outpatients (49.7% female, mean [SD] age = 45 [15] years) with DSM-IV-diagnosed major depr
  • PMID 24500245
  • GSK3β, CREB, and BDNF in peripheral blood of patients with Alzheimer's disease and depression.
  • Pláteník J1, Fišar Z2, Buchal R1, Jirák R3, Kitzlerová E3, Zvěřová M3, Raboch J3.Author information 1Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Kateřinská 32, 121 08 Prague 2, Czech Republic.2Department of Psychiatry, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Ke Karlovu 11, 120 00 Prague 2, Czech Republic. Electronic address: zfisar@lf1.cuni.cz.3Department of Psychiatry, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Ke Karlovu 11, 120 00 Prague 2, Czech Republic.AbstractBACKGROUND: Glycogen synthase kinase-3β (GSK3β), cAMP-response element-binding protein (CREB) and brain-derived neurotrophic factor (BDNF) play critical roles in neuronal survival, synaptic plasticity and memory and participate in the pathophysiology of both depressive disorder and Alzheimer's disease (AD).
  • Progress in neuro-psychopharmacology & biological psychiatry.Prog Neuropsychopharmacol Biol Psychiatry.2014 Apr 3;50:83-93. doi: 10.1016/j.pnpbp.2013.12.001. Epub 2013 Dec 12.
  • BACKGROUND: Glycogen synthase kinase-3β (GSK3β), cAMP-response element-binding protein (CREB) and brain-derived neurotrophic factor (BDNF) play critical roles in neuronal survival, synaptic plasticity and memory and participate in the pathophysiology of both depressive disorder and Alzheimer's dis
  • PMID 24334212
  • Major depressive disorder in breast cancer: A critical systematic review of pharmacological and psychotherapeutic clinical trials.
  • Carvalho AF1, Hyphantis T2, Sales PM3, Soeiro-de-Souza MG4, Macêdo DS5, Cha DS6, McIntyre RS7, Pavlidis N8.Author information 1Psychiatry Research Group, Faculty of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil; Department of Clinical Medicine, Faculty of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil. Electronic address: andrefc7@terra.com.br.2Department of Psychiatry, Medical School, University of Ioannina, Ioannina, Greece.3Psychiatry Research Group, Faculty of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil.4Mood Disorders Unit (GRUDA), Institute and Department of Psychiatry, School of Medicine, University of São Paulo, São Paulo, SP, Brazil.5Psychiatry Research Group, Faculty of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil; Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, Fortaleza, CE, Brazil.6Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, ON, Canada; Institute of Medical Science, University of Toronto, Toronto, ON, Canada.7Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, ON, Canada; Institute of Medical Science, University of Toronto, Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada.8Department of Medical Oncology, Medical School, University of Ioannina, Ioannina, Greece.AbstractBACKGROUND: While women with breast cancer often face varying levels of psychological distress, there is a subgroup whose symptomatology reaches a threshold for diagnosis of major depressive disorder (MDD). Major depressive disorder is known to influence patient outcomes, such as health-related quality of life and treatment adherence. There are no systematic reviews that evaluate pharmacological and psychotherapeutic treatment trials for MDD among individuals with breast cancer.
  • Cancer treatment reviews.Cancer Treat Rev.2014 Apr;40(3):349-55. doi: 10.1016/j.ctrv.2013.09.009. Epub 2013 Sep 14.
  • BACKGROUND: While women with breast cancer often face varying levels of psychological distress, there is a subgroup whose symptomatology reaches a threshold for diagnosis of major depressive disorder (MDD). Major depressive disorder is known to influence patient outcomes, such as health-related qual
  • PMID 24084477
  • The role of controlled attention on recall in major depression.
  • Ellis AJ, Wells TT, Vanderlind WM, Beevers CG.Author information a Semel Institute of Neuroscience and Human Behaviour , University of California , Los Angeles , CA , USA.AbstractInformation processing biases are hallmark features of major depressive disorder (MDD). Depressed individuals display biased memory and attention for negative material. Given that memory is highly dependent on attention for initial encoding, understanding the interplay of these processes may provide important insight into mechanisms that produce memory biases in depression. In particular, attentional control-the ability to selectively attend to task-relevant information by both inhibiting the processing of irrelevant information and disengaging attention from irrelevant material-may be one area of impairment in MDD. In the current study, clinically depressed (MDD: n = 15) and never depressed (non-MDD: n = 22) participants' line of visual gaze was assessed while participants viewed positive and negative word pairs. For each word pair, participants were instructed to attend to one word (target) and ignore one word (distracter). Free recall of study stimuli was then assessed. Depressed individuals displayed greater recall of negatively valenced target words following the task. Although there were no group differences in attentional control in the context of negative words, attention to negative targets mediated the relationship between depression status and recall of negative words. Results suggest a stronger link between attention and memory for negative material in MDD.
  • Cognition & emotion.Cogn Emot.2014 Apr;28(3):520-9. doi: 10.1080/02699931.2013.832153. Epub 2013 Sep 6.
  • Information processing biases are hallmark features of major depressive disorder (MDD). Depressed individuals display biased memory and attention for negative material. Given that memory is highly dependent on attention for initial encoding, understanding the interplay of these processes may provide
  • PMID 24006889

和文文献

  • 非定型うつ病 : パーソナリティ特性・障害に関連したうつ病の診療覚書 (特集 うつ病の亜型分類への展望(その1))
  • 内因性うつ病 : 概念史と現代的意義 (特集 うつ病の亜型分類への展望(その1))
  • 軽症うつ病:病態と治療の考え方 : うつ病治療の古くからある,そして忘れられつつあるストラテジー
  • 大前 晋
  • Depression strategy : うつ病治療の新たなストラテジー 3(2), 1-3, 2013-06
  • NAID 40019748761
  • 高齢透析患者の療養生活における体験の意味づけ
  • 田中 紀子,原田 小夜,太田 節子
  • 聖泉看護学研究 2, 69-81, 2013-04
  • 背景 近年,透析治療の進歩による生存寿命の長期化と導入の高齢化により,高齢透析患者が年々増加している.透析治療の受容には,認知機能が影響することから,年齢が高くなるほど透析治療の受容は悪いことが指摘されている.しかし,高齢透析患者の多くは,透析治療を休むことや放棄することなく治療を継続しており,そこには透析の受容とは異なる療養生活における体験の意味づけがあると考えられる.目的 本研究は,高齢透析患 …
  • NAID 110009585898

関連リンク

Directed by Lars von Trier. With Kirsten Dunst, Charlotte Gainsbourg, Kiefer Sutherland, Alexander Skarsgård. Two sisters find their already strained relationship challenged as a mysterious new planet threatens to collide with Earth.
全て一つになっている化粧品を使うと、スキンケアまでできて、手間はかからないし、便利な物です。 私は、いつもは、化粧水から始まって、クリームまで、順番につけて行きます。 ある日知人が、あなた、今日は体調が悪いの ...
Melancholia - A beautiful movie about the end of the world - by Lars von Trier ... Well, it's hard to smuggle in a bit of ugliness. So I think the film is slightly on the edge of plastic. Here and there. Would you please write that?

関連画像

Film Comment: Melancholia (2011)directed by Silvio Narizzano as claire in lars von trier s melancholiaMelancholia: when worlds collide MELANCHOLIAmelancholia-von-trierMelancholiaMelancholia: when worlds collide


★リンクテーブル★
先読みdepression
リンク元うつ病」「抑欝」「depressive disorder」「depressive syndrome」「endogenous depression

depression」

  [★]

D, 低下、うつ病
  • n.
  • 押し下げること、下降、沈下、陥没
  • くぼみ、窪地、低地、陥凹
  • 意気消沈、憂鬱、ふさぎ。(精神医)鬱病、よくうつ、メランコリー
  • 不振、低下、減退。(経済)不景気、不況
  • (生理)機能低下


WordNet   license wordnet

「a concavity in a surface produced by pressing; "he left the impression of his fingers in the soft mud"」
impression, imprint

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「a long-term economic state characterized by unemployment and low prices and low levels of trade and investment」
slump, economic crisis

WordNet   license wordnet

「a mental state characterized by a pessimistic sense of inadequacy and a despondent lack of activity」

WordNet   license wordnet

「angular distance below the horizon (especially of a celestial object)」

WordNet   license wordnet

「pushing down; "depression of the space bar on the typewriter"」

WordNet   license wordnet

「sad feelings of gloom and inadequacy」

PrepTutorEJDIC   license prepejdic

「〈C〉『くぼ地』,くぼみ / 〈U〉〈C〉『意気消沈』,憂うつ;うつ病 / 〈C〉『不景気』,不況 / 〈U〉押し下げること,降下,低下」


うつ病」

  [★] 鬱病

depression
抗うつ薬抑うつ症メランコリー melancholia

分類

  • 一次
  • 大うつ病性障害(単極性障害)
  • 双極性障害
  • 気分変調性障害
  • 気分循環性障害
  • 特別な気分障害
  • 産後うつ病
  • 季節性気分障害
  • 二次
  • 薬物の使用による

疫学

  • 世界的に有病率が高い(十ヵ国を対象とした研究では生涯有病率は平均8-12%、日本では3%、米国では17%であった(参考2))  097G008(うつ病は世界的に主要な健康問題になっている。)

病因

  • 脳のノルエピネフリン神経、セロトニン神経の働きに異常
  • レセルピンと鬱病の関係
  • レセルピン
  • 血圧低下作用が臨床応用されていた
  • 1931年に鎮静作用を示すことが明らかにされていた。
  • ノルエピネフリン神経におけるシナプス小胞への取り込みを阻害することによって
血圧↓→脳内モノアミン枯渇→うつ病発症→使われなくなる

評価

鬱の診断基準

also see DSM-IV
  • 1. 抑うつ気分
  • 気分の落ち込みや何をしても癒されない気分や空虚感など
  • 2. 興味、喜びの喪失
  • 感情が麻痺した状態

診断

鑑別診断

KPS.973 ← あまり整理されていない印象
  • 抑うつ気分を伴う適応障害
  • 気分変調性障害
  • 失調感情障害
  • 統合失調症
  • 大うつ病性障害
  • 双極I型障害
  • 境界性人格障害
  • 低カリウム血症
  • 短期精神病性障害
  • 気分循環性障害
  • 抗高血圧性毒性
  • ステロイド精神病性障害
  • 甲状腺機能低下症
  • 脳腫瘍
  • 全身不全麻痺
  • アンフェタミン使用障害
  • コカイン使用障害
  • 膵癌
  • 肝炎
  • ウイルス感染後症候群
  • アルツハイマー型認知症
  • 血管性認知症
  • 晩発性アルツハイマー型認知症
  • 早発性アルツハイマー型認知症
  • 肝硬変
  • 動脈硬化症
  • 伝染性単核球症
  • 甲状腺機能亢進症
  • 潜在性悪性腫瘍
  • エイズ
  • シゾイド人格障害/統合失調質人格障害
  • 失調型人格障害/統合失調型人格障害
IMD.1077 PSY.284
  • 二次性:
  • 脳器質性疾患
  • 脳血管障害:脳梗塞、脳出血など:CT、MRI、神経学的所見などから鑑別する
  • 脳変性疾患:パーキンソン病アルツハイマー病:CT、MRI、神経学的所見などから鑑別する

症状

昏迷、不安焦燥、精神活動抑制、微小思考
  • 気分の憂うつだったり、寂しくなったりという抑うつ気分
  • 将来に希望を持てなくて悲観的になり、考ええばかりおそってくる抑うつ気分
  • 意欲、興味、関心の低下をきたす
  • 朝に抑うつ気分がひどい
  • 症状がひどいと自殺を試みる

治療

方針

  • 1. うつ病であることを説明
  • 2. 休息
  • 3. 治癒の見通しを明らかにする
  • 4. 重要決定は延期させる
  • 5. 自殺しない約束

modality

  • 薬物療法
効果の発現は服用開開始から1-2週間後で即効性はない。鬱症状が改善した後も4ヶ月継続すべき。(PSY.288)
軽症~中等症:SSRI, SNRI
重症:三環系抗うつ薬
  • 精神療法
  • 身体療法
  • 電気痙攣療法 electroconvulsive therapy ECT:薬物療法に反応しない薬物治療抵抗性うつ病が適応。自殺の危険が迫っている例、身体疾患もしくは副作用により薬物療法に耐えられない例も適応。修正型電気痙攣療法もある。
  • 高照度光療法:季節性感情障害 SADが適応。

薬物療法

  • MAOとうつ病
  • MAO inhibitorは脳モノアミン神経伝達物質の量を増やす
  • MAO inhibitor
  • モノアミン神経伝達物質が蓄積される
  • パーキンソン病やうつ病の病状をよくする

参考

  • 1. [charged] うつ病の疫学、病因、および神経生物学 - uptodate [1]



抑欝」

  [★]

depressionmelancholia
うつ病、低下、抑圧抑制うつうつ状態鬱病メランコリー抑うつ抑うつ状態
-melancholia


depressive disorder」

  [★]

depressive illnessdepressive neurosisdepressive syndromeendogenous depressionmelancholiaunipolar depression


depressive syndrome」

  [★]

depressive disorderdepressive neurosisendogenous depressionmelancholiaunipolar depression

endogenous depression」

  [★]

depressive disorderdepressive neurosisdepressive syndromemelancholiaunipolar depression




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