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1. 巨核球の生物学と血小板の産生 megakaryocyte biology and the production of platelets
2. 鉄芽球性貧血の臨床的側面、診断、および治療 clinical aspects diagnosis and treatment of the sideroblastic anemias
3. 先天性および後天性血小板機能障害 congenital and acquired disorders of platelet function
4. 家族性急性白血病および骨髄異形成症候群 familial acute leukemia and myelodysplastic syndromes
5. 自動血液分析装置 automated hematology instrumentation

English Journal

PMID 25753067

Impact of preeclampsia on megakaryocytopoesis and platelet homeostasis of preterm infants.

Yang J1, Zhang H, Niu J, Mu X, Zhang X, Liu Y, Wang J, Chen Y.
Platelets.Platelets.2015 Jun 17:1-5. [Epub ahead of print]
The aim of this article is to investigate the megakaryopoyesis and thrombopoiesis in preterm infants born to mothers with preeclampsia and the potential effects mediated by soluble fms-like tyrosine kinase 1 (sFlt1) and thrombopoietin (TPO). A perspective case-control study was performed on 26 cord
PMID 26083681

Phytosphingosine promotes megakaryocytic differentiation of myeloid leukemia cells.

Han SH, Kim J, Her Y, Seong I, Park S, Bhattara D, Jin G, Lee K, Chung G, Hwang S, Bae YS, Kim J1.
BMB reports.BMB Rep.2015 Jun 16. pii: 3239. [Epub ahead of print]
We report that Pytosphingosine, a sphingolipid found in many organisms and implicated in cellular signaling, promotes megakaryocytic differentiation of myeloid leukemia cells. Specifically, Pytosphingosine induced several hallmark changes associated with megakaryopoiesis from K562 and HEL cells incl
PMID 26077028

Japanese Journal

CLEC-2による生体応答制御 (特集 C型レクチン受容体による生体応答制御)

臨床免疫・アレルギー科 = Clinical immunology & allergology 66(2), 122-128, 2016-08
NAID 40020941233

GATA-dependent regulation of TPO-induced <i>c-mpl</i> Gene Expression during Megakaryopoiesis

Okajimas Folia Anatomica Japonica 90(4), 101-106, 2014
NAID 130004495133

Congenital amegakaryocytic thrombocytopenia iPS cells exhibit defective MPL-mediated signaling.

The Journal of clinical investigation, 2013-08-01
NAID 120005312065

Related Links

Megakaryopoiesis - National Center for Biotechnology Information

TPO signaling in megakaryopoiesis Multiple growth factors support megakaryopoesis, the most important of which is thrombopoietin (TPO). TPO belongs to the four-helix bundle family of cytokines, which includes erythropoietin, G ...

megakaryopoiesis - definition of megakaryopoiesis by Medical ...

megakaryopoiesis megakaryocytopoiesis. ... However, according to more recent studies, these autoantibodies, directed against glycoproteins of the integrin family, also prevent formation of new platelets via inhibited megakaryopoiesis or destruction of megakaryocytes within the bone marrow.