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Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/08/16 12:26:50」(JST)
[Wiki en表示]
Medrysone
|
| Systematic (IUPAC) name |
|
(6S,8S,9S,10R,11S,13R,14S,17S)- 17-acetyl-11-hydroxy-6,10,13-trimethyl-1,2,6,7,8,9,
11,12,14,15,16,17- dodecahydrocyclopenta[a] phenanthren-3-one
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| Clinical data |
| AHFS/Drugs.com |
Micromedex Detailed Consumer Information |
| MedlinePlus |
a606003 |
Pregnancy
category |
- US: C (Risk not ruled out)
|
| Legal status |
|
Routes of
administration |
Eye drops |
| Identifiers |
| CAS Registry Number |
2668-66-8 Y |
| ATC code |
S01BA08 |
| PubChem |
CID: 247839 |
| IUPHAR/BPS |
7086 |
| DrugBank |
DB00253 N |
| ChemSpider |
216968 N |
| UNII |
D2UFC189XF N |
| KEGG |
D02289 Y |
| ChEMBL |
CHEMBL1201173 N |
| Chemical data |
| Formula |
C22H32O3 |
| Molecular mass |
344.488 g/mol |
SMILES
-
C[C@H]1C[C@H]2[C@@H]3CC[C@@H]([C@]3(C[C@@H]([C@@H]2[C@@]4(C1=CC(=O)CC4)C)O)C)C(=O)C
|
InChI
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InChI=1S/C22H32O3/c1-12-9-15-17-6-5-16(13(2)23)22(17,4)11-19(25)20(15)21(3)8-7-14(24)10-18(12)21/h10,12,15-17,19-20,25H,5-9,11H2,1-4H3/t12-,15-,16+,17-,19-,20+,21-,22+/m0/s1 N
-
Key:GZENKSODFLBBHQ-ILSZZQPISA-N N
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| N (what is this?) (verify) |
Medrysone is a corticosteroid that has been used in optometry[citation needed], and in ophthalmology for the treatment of eye inflammations.[1][2] It has been discontinued in the US.[2]
See also
References
- ^ Rastogi, R. K.; Mathur, A.; Raizada, I. N. (1985). "Efficacy of medrysone as anti-inflammatory agent". Indian journal of ophthalmology 33 (5): 295–297. PMID 3843339. edit
- ^ a b Medrysone Micromedex Detailed Consumer Information
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Glucocorticoids and antiglucocorticoids (H02)
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|
| Agonists |
| Pregnene |
|
|
| Pregnenedione |
- Hydrocortisone (cortisol)# (Hydrocortisone aceponate
- Hydrocortisone buteprate
- Hydrocortisone butyrate)
- Budesonide
- Ciclesonide
- Deflazacort
- Medrysone
- Tixocortol
- HALOGENATED AT 6: Cloprednol
- HALOGENATED, WITH FG AT 16: Halcinonide
|
|
| Pregnadiene |
- Rimexolone
- HALOGENATED, WITH FG AT 16: Flunisolide
- Triamcinolone
- Amcinonide
- Fluocinolone acetonide (Fluocinonide)
|
|
| Pregnadienediol |
- Prednisone (Meprednisone)
- HALOGENATED AT 9: Fluorometholone
- HALOGENATED, WITH FG AT 16: Fluocortolone (Clocortolone
- Diflucortolone
- Fluocortin)
- Desoximetasone
|
|
| Pregnadienetriol |
- Prednisolone# (Methylprednisolone
- Methylprednisolone aceponate
- Prednicarbate
- Prednylidene)
- Desonide
- HALOGENATED: Fluprednisolone (Difluprednate
- Fluperolone)
- HALOGENATED, WITH FG AT 16: Dexamethasone#
- Betamethasone (Clobetasol
- Clobetasone
- Diflorasone
- Halometasone
- Ulobetasol)
- Beclometasone
- Paramethasone
- Alclometasone
- Fluclorolone acetonide
- Flumetasone
- Fluprednidene
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|
| Pregnatriene |
|
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| Androstene |
- HALOGENATED, WITH FG AT 16: Fluticasone (Fluticasone propionate
- Fluticasone furoate)
|
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| Others/unsorted |
- HALOGENATED: Loteprednol
- HALOGENATED, WITH FG AT 16: Fludroxycortide
- Formocortal
- Mometasone furoate
- Promestriene
|
|
|
Antagonists /
SGRMs |
- Antagonists: Ketoconazole
- Mifepristone
|
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| Synthesis modifiers |
- Acetoxolone
- Aminoglutethimide
- Carbenoxolone
- Enoxolone
- Ketoconazole
- Metyrapone
- Mitotane
- Trilostane
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|
-
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
|
|
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Index of hormones
|
|
| Description |
- Glands
- Hormones
- thyroid
- mineralocorticoids
- Physiology
- Development
|
|
| Disease |
- Diabetes
- Congenital
- Neoplasms and cancer
- Other
- Symptoms and signs
|
|
| Treatment |
- Procedures
- Drugs
- calcium balance
- corticosteroids
- oral hypoglycemics
- pituitary and hypothalamic
- thyroid
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Glucocorticoid signaling
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Receptor
(ligands) |
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GR
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Agonists
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|
|
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Mixed (SEGRAs)
|
- Dagrocorat
- Fosdagrocorat
- Mapracorat
|
|
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Antagonists
|
- 3α-Hydroxytibolone
- 3β-Hydroxytibolone
- Aglepristone
- Asoprisnil
- C108297
- C113176
- CORT-108297
- Cyproterone acetate
- Ketoconazole
- Lilopristone
- LLY-2707
- Miconazole
- Mifepristone
- Onapristone
- Org 34850
- PCN
- Telapristone
- Tibolone
- Toripristone
- Ulipristal acetate
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|
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Enzyme
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Modulators
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- 20,22-desmolase, 17α-hydroxylase/17,20-lyase, 3β-HSD, 11β-HSD, 21-hydroxylase, 11β-hydroxylase, and 18-hydroxylase) (see also Steroid hormone metabolism modulators)
|
|
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| Others |
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Precursors/prohormones
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- Cholesterol
- 22R-Hydroxycholesterol
- 20α,22R-Dihydroxycholesterol
- Pregnenolone
- Pregnenolone sulfate
- 17-Hydroxypregnenolone
- Progesterone
- 17-Hydroxyprogesterone
- 11-Deoxycorticosterone
|
|
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Indirect
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- ACTH (corticotropin)
- CRH
- DHEA
- DHEA sulfate
- Plasma proteins (albumin, transcortin)
- Vasopressin
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See also: Androgenics • Estrogenics • Mineralocorticoids • Progestogenics
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UpToDate Contents
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English Journal
- New Anti-Inflammatory Metabolites by Microbial Transformation of Medrysone.
- Bano S1, Wahab AT2, Yousuf S1, Jabeen A2, Mesaik MA3, Rahman AU1, Choudhary MI1,2,4.
- PloS one.PLoS One.2016 Apr 22;11(4):e0153951. doi: 10.1371/journal.pone.0153951. eCollection 2016.
- Microbial transformation of the anti-inflammatory steroid medrysone (1) was carried out for the first time with the filamentous fungi Cunninghamella blakesleeana (ATCC 8688a), Neurospora crassa (ATCC 18419), and Rhizopus stolonifer (TSY 0471). The objective was to evaluate the anti-inflammatory pote
- PMID 27104348
- LC-MS/MS method for determination of megestrol in human plasma and its application in bioequivalence study.
- Li F1, Zou XJ, Zheng H, Xiang Y.
- Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban.J Huazhong Univ Sci Technolog Med Sci.2013 Dec;33(6):912-6. doi: 10.1007/s11596-013-1221-9. Epub 2013 Dec 13.
- A rapid and highly selective liquid chromatography-tandem mass spectrometric (LC-MS/MS) method for the determination of megestrol in human plasma was described using medrysone as internal standard (IS). Blood samples were collected from 20 healthy volunteers after oral administration of 160 mg meges
- PMID 24337858
- [Effects of electroacupuncture of Sanyinjiao (SP 6) on genito-endocrine in patients with perimenopausal syndrome].
- Qin ZY1, Ling H, Xia XH, Meng L, Wu ZJ.
- Zhen ci yan jiu = Acupuncture research / [Zhongguo yi xue ke xue yuan Yi xue qing bao yan jiu suo bian ji].Zhen Ci Yan Jiu.2007 Aug;32(4):255-9.
- OBJECTIVE: To observe the regulative effect of electroacupuncture (EA) of Sanyinjiao (SP 6) on genito-endocrine in patients with perimenopausal syndrome (PMS).METHODS: A total of 175 PMS patients (157 cases with complete data) were randomized into EA group (n=81) and medication group (n=76) accordin
- PMID 17907389
Japanese Journal
- 前眼部炎性疾患に対する1.0%Medrysoneと0.01%Betamethasone(Rinderon)の消炎効果に対する二重盲検法による検討
- 葉田野 博,萱場 忠一郎,児玉 寛典
- ＣＨＥＭＯＴＨＥＲＡＰＹ 33(Supplement2), 804-809, 1985
- Fundamental and clinical studies on sultamicillin were carried out in the field of ophthalmology, and the following results were obtained.<BR>1. The MICs of sultamicillin against <I>S. aur …
- NAID 130004072182
- MedrysoneとBetamethasoneの眼圧への影響
- 眼圧上昇のないステロイドHydroxymesterone(medrysone)
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