- dorsal medial nucleus、dorsomedial nucleus、dorsomedial thalamic nucleus、medial dorsal nucleus、mediodorsal thalamic nucleus
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/07/23 12:04:24」(JST)[Wiki en表示]
- Noradrenaline and acetylcholine responsiveness of glucose-monitoring and glucose-insensitive neurons in the mediodorsal prefrontal cortex.
- Nagy B1, Szabó I2, Csetényi B2, Hormay E2, Papp S2, Keresztes D2, Karádi Z2.Author information 1Pécs University, Medical School, Institute of Physiology, and Molecular Neurophysiology Research Group, Pécs University Szentágothai Research Center, Pécs, Hungary. Electronic address: firstname.lastname@example.orgPécs University, Medical School, Institute of Physiology, and Molecular Neurophysiology Research Group, Pécs University Szentágothai Research Center, Pécs, Hungary.AbstractThe mediodorsal prefrontal cortex (mdPFC), as part of the forebrain glucose-monitoring (GM) system, plays important role in several regulatory processes to control the internal state of the organism and to initiate behavioral outputs accordingly. Little is known, however, about the neurochemical sensitivity of neurons located in this area. Substantial evidence indicates that the locus ceruleus - noradrenaline (NA) projection system and the nucleus basalis magnocellularis - cholinergic projection system regulate behavioral state and state dependent processing of sensory information, various cognitive functions already associated with the mdPFC. The main goal of the present study was to examine noradrenergic and cholinergic responsiveness of glucose-monitoring and glucose-insensitive (GIS) neurons in the mediodorsal prefrontal cortex. One fifth of the neurons tested changed in firing rate to microelectrophoretically applied NA. Responsiveness of the GM cells to this catecholamine proved to be significantly higher than that of the GIS units. Microiontophoretic application of acetylcholine (Ach) resulted in activity changes (predominantly facilitation) of more than 40% of the mdPFC neurons. Proportion of Ach sensitive units among the GM and the GIS neurons was found to be similar. The glucose-monitoring neurons of the mdPFC and their distinct NA and remarkable Ach sensitivity are suggested to be of particular significance in prefrontal control of adaptive behaviors.
- Brain research.Brain Res.2014 Jan 16;1543:159-64. doi: 10.1016/j.brainres.2013.11.014. Epub 2013 Nov 16.
- The mediodorsal prefrontal cortex (mdPFC), as part of the forebrain glucose-monitoring (GM) system, plays important role in several regulatory processes to control the internal state of the organism and to initiate behavioral outputs accordingly. Little is known, however, about the neurochemical sen
- PMID 24252621
- Brief maternal separation affects brain α1-adrenoceptors and apoptotic signaling in adult mice.
- Coccurello R, Bielawski A, Zelek-Molik A, Vetulani J, Kowalska M, D'Amato FR, Nalepa I.Author information Institute of Cell Biology and Neurobiology (IBCN), National Research Council (CNR)/S. Lucia Foundation, Via del Fosso di Fiorano 64, 00143 Rome, Italy.AbstractExposure to adversity during early life is a risk factor for the development of different mood and psychiatric disorders, including depressive-like behaviors. Here, neonatal mice were temporarily but repeatedly (day 1 to day 13) separated from mothers and placed in a testing environment containing a layer of odorless clean bedding (CB). We assessed in adult animals the impact of this early experience on binding sites and mRNA expression of α1-adrenergic receptor subtypes, heat shock proteins (HSPs) and proapoptotic and antiapoptotic members of the Bcl-2 family proteins in different brain regions involved in processing of olfactory information and rewarding stimuli. We found that repeated exposure to CB experience produced anhedonic-like behavior in terms of reduced saccharin intake and α1-adrenoceptor downregulation in piriform and somatosensory cortices, hippocampus, amygdala and discrete thalamic nuclei. We also found a selective decrease of α1B-adrenoceptor binding sites in the cingulate cortex and hippocampus and an increase of hippocampal α1A and α1B receptor, but not of α1D-adrenoceptor, mRNA levels. Moreover, while a significant decrease of antiapoptotic heat shock proteins Hsp72 and Hsp90 was identified in the prefrontal cortex, a parallel increase of antiapoptotic members of Bcl-2 family proteins was found at the hippocampal level. Together, these data provide evidence that the early exposure to CB experience produced enduring downregulation of α1-adrenoceptors in the prefrontal-limbic forebrain/limbic midbrain network, which plays a key role in the processing of olfactory information and reaction to rewarding stimuli. Finally, these data show that CB experience can "prime" the hippocampal circuitry and promote the expression of antiapoptotic factors that can confer potential neuroprotection to subsequent adversity.
- Progress in neuro-psychopharmacology & biological psychiatry.Prog Neuropsychopharmacol Biol Psychiatry.2014 Jan 3;48:161-9. doi: 10.1016/j.pnpbp.2013.10.004. Epub 2013 Oct 12.
- Exposure to adversity during early life is a risk factor for the development of different mood and psychiatric disorders, including depressive-like behaviors. Here, neonatal mice were temporarily but repeatedly (day 1 to day 13) separated from mothers and placed in a testing environment containing a
- PMID 24128685
- Impaired executive function following ischemic stroke in the rat medial prefrontal cortex.
- Cordova CA, Jackson D, Langdon KD, Hewlett KA, Corbett D.Author information Division of BioMedical Sciences, Memorial University, St. John's, NL, Canada; Heart and Stroke Foundation Centre for Stroke Recovery, Canada.AbstractSmall (lacunar) infarcts frequently arise in frontal and midline thalamic regions in the absence of major stroke. Damage to these areas often leads to impairment of executive function likely as a result of interrupting connections of the prefrontal cortex. Thus, patients experience frontal-like symptoms such as impaired ability to shift ongoing behavior and attention. In contrast, executive dysfunction has not been demonstrated in rodent models of stroke, thereby limiting the development of potential therapies for human executive dysfunction. Male Sprague-Dawley rats (n=40) underwent either sham surgery or bilateral endothelin-1 injections in the mediodorsal nucleus of the thalamus or in the medial prefrontal cortex. Executive function was assessed using a rodent attention set shifting test that requires animals to shift attention to stimuli in different stimulus dimensions. Medial prefrontal cortex ischemia impaired attention shift performance between different stimulus dimensions while sparing stimulus discrimination and attention shifts within a stimulus dimension, indicating a selective attention set-shift deficit. Rats with mediodorsal thalamic lacunar damage did not exhibit a cognitive impairment relative to sham controls. The selective attention set shift impairment observed in this study is consistent with clinical data demonstrating selective executive disorders following stroke within specific sub-regions of frontal cortex. These data contribute to the development and validation of a preclinical animal model of executive dysfunction, that can be employed to identify potential therapies for ameliorating cognitive deficits following stroke.
- Behavioural brain research.Behav Brain Res.2014 Jan 1;258:106-11. doi: 10.1016/j.bbr.2013.10.022. Epub 2013 Oct 19.
- Small (lacunar) infarcts frequently arise in frontal and midline thalamic regions in the absence of major stroke. Damage to these areas often leads to impairment of executive function likely as a result of interrupting connections of the prefrontal cortex. Thus, patients experience frontal-like symp
- PMID 24144544
- The mediodorsal nucleus of the human thalamus is in a crucial position that allows it to establish connections with diverse cerebral structures, particularly the prefrontal cortex. The present review examines existing ...
- Mediodorsal Nucleus Of Thalamus The mediodorsal nucleus (MD) of the thalamus has reciprocal projections with the frontal cortex and limbic system, and may be involved in absence seizures. Ultrastructural analysis in the ...
|リンク元||「dorsal medial nucleus」「medial dorsal nucleus」「dorsomedial thalamic nucleus」「mediodorsal thalamic nucleus」|
- dorsomedial nucleus、dorsomedial thalamic nucleus、medial dorsal nucleus、mediodorsal nucleus、mediodorsal thalamic nucleus
- dorsal medial nucleus、dorsomedial nucleus、dorsomedial thalamic nucleus、mediodorsal nucleus、mediodorsal thalamic nucleus
- dorsal medial nucleus、dorsomedial nucleus、medial dorsal nucleus、mediodorsal nucleus、mediodorsal thalamic nucleus
- dorsal medial nucleus、dorsomedial nucleus、dorsomedial thalamic nucleus、medial dorsal nucleus、mediodorsal nucleus
- cell nucleus, karyon