mean cell hemoglobin concentration

平均赤血球血色素濃度

WordNet

1. have a specified degree of importance; "My ex-husband means nothing to me"; "Happiness means everything"
2. an average of n numbers computed by adding some function of the numbers and dividing by some function of n (同)mean_value
3. mean or intend to express or convey; "You never understand what I mean!"; "what do his words intend?" (同)intend
4. denote or connote; "`maison means `house in French"; "An example sentence would show what this word means" (同)intend, signify, stand_for
5. (used of persons or behavior) characterized by or indicative of lack of generosity; "a mean person"; "he left a miserly tip" (同)mingy, miserly, tight
6. destine or designate for a certain purpose; "These flowers were meant for you"
7. excellent; "famous for a mean backhand"
8. the spatial property of being crowded together (同)density, denseness, tightness, compactness
9. bringing together military forces
10. strengthening the concentration (as of a solute in a mixture) by removing diluting material
11. the strength of a solution; number of molecules of a substance in a given volume
12. complete attention; intense mental effort (同)engrossment, absorption, immersion
13. increase in density
14. small room in which a monk or nun lives (同)cubicle
15. a device that delivers an electric current as the result of a chemical reaction (同)electric cell
16. a room where a prisoner is kept (同)jail cell, prison cell
17. (biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
18. any small compartment; "the cells of a honeycomb"
19. a small unit serving as part of or as the nucleus of a larger political movement (同)cadre
20. rich in significance or implication; "a meaning look" (同)pregnant, significant
21. the message that is intended or expressed or signified; "what is the meaning of this sentence"; "the significance of a red traffic light"; "the signification of Chinese characters"; "the import of his announcement was ambiguous" (同)significance, signification, import
22. the idea that is intended; "What is the meaning of this proverb?" (同)substance
23. considerable capital (wealth or income); "he is a man of means" (同)substance
24. how a result is obtained or an end is achieved; "a means of control"; "an example is the best agency of instruction"; "the true way to success" (同)agency, way
25. an instrumentality for accomplishing some end

PrepTutorEJDIC

1. 〈人が〉…‘を'『意図する』,‘の'つもりである;…‘を'言おうとある;示そうとする / 〈単語・句・文章などが〉…‘を'『意味を持つ』,‘を'『意味する』 / (人に対して)…‘を'当てる,向ける《+『名』+『for』+『名』》 / 《受動態で》〈人・物〉‘を'(…)向きにする / 〈物事が〉…‘を'示す,表す / (結果として)〈物事が〉…‘を'もたらす,生じさせる / 《『mean』+『for』+『名』+『to』 do》《米話》(…が…するような)つもりでいる
2. 《名詞の前にのみ用いて》(品質・価値・才能などが)『劣った』,つまらない / (人・行為などが)『卑劣な』,さもしい / 《古》(身分・地位などが)卑しい / 《まれ》(身なり・建物などが)みずぼらしい,見るもあわれな / 《米話》(動物が)御しにくい;(一般に)扱いにくい
3. 中庸,中道 / (数学で) / 平均[値];(特に)算術平均,相加平均 / (比例式の)中項,内項 / (両極端の)中間の,中央に位置する / (大きさ・品質・程度などが)平均的な,平均の
4. 〈U〉(…への)(光線・注意などの)集中;(仕事などへの)専念,専心《+『on』+『名』》 / 〈C〉(人口などの)集中 / 〈U〉濃縮;〈液体の〉濃度
5. (刑務所の)『独房』;(修道院の)小さい独居室 / (ミツバチの)みつ房,巣穴 / 小さい部屋 / 『細胞』 / 電池 / 花粉室 / (共産党などの)細胞
6. (・・・の)『目的』,意義《+『of』+『名』》 / (吾・文の)『意味』(sense)《+『of』+『名』》 / 意味ありげな様子,意味深長 / 《名詞の前にのみ用いて》意味ありげな,意味常長な / 《複合吾を作って》・・・するつもりの,の意図をもった
7. 〈C〉《単数・複数扱い》『方法』,『手段』 / 《複数扱い》『資力』,『財産』,富

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/09/22 08:18:37」(JST)

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hemoglobin

The mean corpuscular hemoglobin concentration, a measure of the concentration of hemoglobin in a given volume of packed red blood cells. It is reported as part of a standard complete blood count.

It is calculated by dividing the hemoglobin by the hematocrit. Reference ranges for blood tests are 32 to 36 g/dl, or between 19.9 to 22.3 mmol/L. It is thus a mass or molar concentration. Still, many instances measure MCHC in percentage (%), as if it were a mass fraction (m_Hb / m_RBC). Numerically, however, the MCHC in g/dl and the mass fraction of hemoglobin in red blood cells in % are identical, assuming a RBC density of 1g/mL and negligible hemoglobin in plasma.

Interpretation

MCHC is diminished ("hypochromic") in microcytic anemias, and normal ("normochromic") in macrocytic anemias (due to larger cell size, though the hemoglobin amount or MCH is high, the concentration remains normal). MCHC is elevated ("hyperchromic") in hereditary spherocytosis, sickle cell disease and homozygous hemoglobin C disease.

This count is used to give a rough guide to what shade of red erythrocytes will be (i.e., the paler the color the lower the MCHC will be than the standard).

Complications with cold agglutinin

Because of the way automated analysers count blood cells, a very high MCHC (greater than about 370 g/L) may indicate the blood is from someone with a cold agglutinin. This means that when their blood gets colder than 37°C it starts to clump together. As a result, the analyzer may incorrectly report a low number of very dense red blood cells for blood samples in which agglutination has occurred.

This problem is usually picked up by the laboratory before the result is reported. The blood is warmed until the cells separate from each other, and quickly put through the machine while still warm.This is the most sensitive test for iron deficiency anemia.

There are four steps to perform when an increase MCHC(>370 g/L or 37.0 g/dL) is received from the analyzer:

1. Remix the EDTA tube—if the MCHC corrects, report corrected results
2. Incubation at 37°C—if the MCHC corrects, report corrected results and comment on possible cold agglutinin
3. Saline replacement: Replace plasma with same amount of saline to exclude interference e.g. Lipemia and Auto-immune antibodies—if the MCHC corrects, report corrected results and comment on Lipemia
4. Check the slide for spherocytosis (e.g. in hereditary spherocytosis, among other causes)

Worked example

Measure	Units	Conventional units	Conversion
Hct	40%
Hb	100 grams/liter	10 grams/deciliter	(deci- is 10-1)
RBC	5E+12 cells/liter	5E+6 cells/μL	(micro is 10-6)
MCV = Hct / RBC	8E-14 liters/cell	80 femtoliters/cell	(femto- is 10-15)
MCH = Hb / RBC	2E-11 grams/cell	20 picograms/cell	(pico- is 10-12)
MCHC = MCH / MCV	250 grams/liter	25 grams/deciliter	(deci is 10-1)

See also

• Red blood cell indices
  • Mean corpuscular volume
  • Mean corpuscular hemoglobin

References

External links

• FP Notebook
• Cornell
• Medline

UpToDate Contents

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• 1. 貧血を有する成人患者に対するアプローチ approach to the adult patient with anemia
• 2. 遺伝性球状赤血球症：臨床的特徴、診断および治療 hereditary spherocytosis clinical features diagnosis and treatment
• 3. 自動血液分析装置 automated hematology instrumentation
• 4. 大赤血球症 macrocytosis
• 5. 赤血球細胞の力学 red blood cell mechanics

English Journal

• Optimizing preoperative haemoglobin in major orthopaedic surgery using intravenous iron with or without erythropoietin. An epidemiologic study.

• Basora M1, Colomina MJ2, Tio M3, Mora L2, Sánchez-Etayo G3, Salazar F3, Ciércoles E2, Paños M2, Guerrero E2, Berge R3.
• Revista espanola de anestesiologia y reanimacion.Rev Esp Anestesiol Reanim.2015 Jun-Jul;62(6):313-321. doi: 10.1016/j.redar.2014.07.011. Epub 2015 Feb 17.
• AIM: To evaluate the effectiveness of intravenous iron treatment, with or without associated erythropoietin (rHuEPO), measured as haemoglobin (Hb) increase. The relationships between the Hb increase and parameters used to evaluate anaemia were analysed.MATERIAL AND METHOD: Retrospective observationa
• PMID 25698609

• Macroscopic optical physiological parameters correlate with microscopic proliferation and vessel area breast cancer signatures.

• Chung SH1, Feldman MD2, Martinez D3, Kim H4, Putt ME5, Busch DR6,7, Tchou J8, Czerniecki BJ9, Schnall MD10, Rosen MA11, DeMichele A12, Yodh AG13, Choe R14.
• Breast cancer research : BCR.Breast Cancer Res.2015 May 27;17(1):72. [Epub ahead of print]
• INTRODUCTION: Non-invasive diffuse optical tomography (DOT) and diffuse correlation spectroscopy (DCS) can detect and characterize breast cancer and predict tumor responses to neoadjuvant chemotherapy, even in patients with radiographically dense breasts. However, the relationship between measured o
• PMID 26013572

• Physiological condition of bank voles (Myodes glareolus) during the increase and decline phases of the population cycle.

• Nieminen P1, Huitu O2, Henttonen H3, Finnilä MA4, Voutilainen L5, Itämies J6, Kärjä V7, Saarela S8, Halonen T9, Aho J10, Mustonen AM11.
• Comparative biochemistry and physiology. Part A, Molecular & integrative physiology.Comp Biochem Physiol A Mol Integr Physiol.2015 May 22. pii: S1095-6433(15)00119-1. doi: 10.1016/j.cbpa.2015.05.007. [Epub ahead of print]
• The dynamics of animal populations are greatly influenced by interactions with their natural enemies and food resources. However, quantifying the relative effects of these factors on demographic rates remains a perpetual challenge for animal population ecology. Food scarcity is assumed to limit the
• PMID 26006298

Japanese Journal

• 28-Day dietary toxicity study of L-phenylalanine in rats

• Shibui Yusuke,Miwa Tadashi,Kodama Terutaka,Gonsho Akinori
• Fundamental Toxicological Sciences 1(2), 29-38, 2014
• … Effects of L-phenylalanine administration were noted in mean body weights and mean body weight gains in females fed 0.5% and in males and females fed 5.0% (w/w) L-phenylalanine diets. … Effects were also noted in mean food consumption in males and females fed the 5.0% (w/w) L-phenylalanine diet. …
• NAID 130005083333

• Use of Proton Pump Inhibitors Is Associated With Anemia in Cardiovascular Outpatients

• Shikata Toshiyuki,Sasaki Naoko,Ueda Masahiro,Kimura Takeshi,Itohara Kanako,Sugahara Masataka,Fukui Miho,Manabe Eri,Masuyama Tohru,Tsujino Takeshi
• Circulation Journal 79(1), 193-200, 2014
• … The effect of PPI on hemoglobin (Hb) concentration, however, has not been clarified in cardiovascular outpatients.Methods and Results:We retrospectively investigated the clinical characteristics of 278 continuous outpatients who received blood test including complete blood count and serum creatinine concentration (mean age, 69.9±10.8 years; …
• NAID 130004927034

• Use of Proton Pump Inhibitors Is Associated With Anemia in Cardiovascular Outpatients

• Shikata Toshiyuki,Sasaki Naoko,Ueda Masahiro,Kimura Takeshi,Itohara Kanako,Sugahara Masataka,Fukui Miho,Manabe Eri,Masuyama Tohru,Tsujino Takeshi
• Circulation Journal, 2014
• … The effect of PPI on hemoglobin (Hb) concentration, however, has not been clarified in cardiovascular outpatients.Methods and Results:We retrospectively investigated the clinical characteristics of 278 continuous outpatients who received blood test including complete blood count and serum creatinine concentration (mean age, 69.9±10.8 years; …
• NAID 130004704018

Related Links

• mean cell hemoglobin concentration - Definition of mean cell ...

+ Add to Word List Create new word list More... Word List Title: 3 to 50 characters max. Word List Description: 3 to 250 characters max. Shared Private Definitions mean cell hemoglobin concentration - Medical Definition noun Abbr. MCHC

• Mean cell hemoglobin concentration definition - Medical ...

Featured Image Picture of Psoriasis A reddish, scaly rash often located over the surfaces of the elbows, knees, scalp, and around or in the ears, navel ... Mean cell hemoglobin concentration: The average concentration of hemoglobin in a given volume of blood.

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関連記事	「mean」「concentration」「means」「meaning」「cell」

「mean」

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(過去-過去分詞meant)

• 意味する

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avenue、average、even、gateway、implication、imply、instrumental、mean value、meaning、means、policy、purport、represent、semantic、sense、tool

　 　 　 　 　 　 　 　 　 　

「concentration」

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• 濃度、濃縮、(精神の)集中

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attention、attentive、centralize、conc.、concentrate、concentrated、condensation、enrich、enrichment、focus

　 　 　 　 　 　 　

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• np.

• 手段、方法

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avenue、fashion、gateway、instrumental、manner、mean、method、mode、policy、procedure、process、tool、way

　 　 　 　

「meaning」

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• n.

• 意味、意義

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consequence、implication、imply、mean、purport、represent、semantic、sense、significance

　 　 　 　

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　　[★] 細胞