matrix metalloproteinase 14

マトリックスメタロプロテアーゼ14

関

MMP-14

WordNet

1. (geology) amass of fine-grained rock in which fossils, crystals, or gems are embedded
2. mold used in the production of phonograph records, type, or other relief surface
3. the body substance in which tissue cells are embedded (同)intercellular substance, ground_substance
4. (mathematics) a rectangular array of quantities or expressions set out by rows and columns; treated as a single element and manipulated according to rules
5. an enclosure within which something originates or develops (from the Latin for womb)
6. the formative tissue at the base of a nail

PrepTutorEJDIC

1. （複数形 matrices, ～・es）(発生・成長の)母体 / 鋳型・模型;(レコードの)原盤;(活字の)母型,字母 / (金属・化石・宝石などの含んだ)母岩・《古》子宮・基盤; (細胞)細胞間質; (地学)基質; (印)字母; 紙型; 鋳型; (鉱)母岩; (数)行列; (コンピュータ)マトリックス (入力導線と出力導線の回路網); (言)母型文 （matrix sentence）
2. マトリクシング(4チャンネルに再生転換できる2チャンネルの録音方式)

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/10/15 10:07:21」(JST)

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Membrane-type matrix metalloproteinase-1
Identifiers
EC number	3.4.24.80
CAS number	161384-17-4
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Membrane-type matrix metalloproteinase-1 (EC 3.4.24.80, matrix metalloproteinase 14) is an enzyme. This enzyme catalyses the following chemical reaction

Endopeptidase activity. Activates progelatinase A by cleavage of the propeptide at Asn³⁷-Leu. Other bonds hydrolysed include Gly35-Ile in the propeptide of collagenase 3, and Asn³⁴¹-Phe, Asp⁴⁴¹-Leu and Gln³⁵⁴-Thr in the aggrecan interglobular domain

This enzyme belongs to peptidase family M10.

See also

• Metalloproteinase

References

External links

• Membrane-type matrix metalloproteinase-1 at the US National Library of Medicine Medical Subject Headings (MeSH)

UpToDate Contents

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• 5. 脳卒中のための血液バイオマーカー blood biomarkers for stroke

English Journal

• miRNA-584-5p exerts tumor suppressive functions in human neuroblastoma through repressing transcription of matrix metalloproteinase 14.

• Xiang X1, Mei H1, Qu H1, Zhao X1, Li D1, Song H1, Jiao W2, Pu J1, Huang K3, Zheng L4, Tong Q5.
• Biochimica et biophysica acta.Biochim Biophys Acta.2015 Sep;1852(9):1743-54. doi: 10.1016/j.bbadis.2015.06.002. Epub 2015 Jun 3.
• Matrix metalloproteinase 14 (MMP-14) is a membrane-anchored MMP crucial for tumorigenesis and aggressiveness, and is highly expressed in neuroblastoma (NB), the most common extracranial solid tumor in childhood. Recent evidence shows the emerging roles of endogenous promoter-targeting microRNAs (miR
• PMID 26047679

• Soluble extracellular matrix metalloproteinase inducer (EMMPRIN, EMN) regulates cancer-related cellular functions by homotypic interactions with surface CD147.

• Knutti N1, Kuepper M2, Friedrich K1.
• The FEBS journal.FEBS J.2015 Aug 16. doi: 10.1111/febs.13414. [Epub ahead of print]
• EMMPRIN (Extracellular matrix metalloproteinase inducer) is a widely expressed glycoprotein and a member of the immunoglobulin superfamily which exists in both a membrane-spanning and a soluble form. Homotypic interactions of EMMPRIN underlie its multiple roles in normal development and pathological
• PMID 26277583

• MMP14 Cleavage of VEGFR1 in the Cornea Leads to a VEGF-Trap Antiangiogenic Effect.

• Han KY1, Dugas-Ford J1, Lee H2, Chang JH1, Azar DT1.
• Investigative ophthalmology & visual science.Invest Ophthalmol Vis Sci.2015 Aug 1;56(9):5450-6. doi: 10.1167/iovs.14-16248.
• PURPOSE: To determine the possible antiangiogenic effect of metalloproteinase (MMP) 14 cleavage of vascular endothelial growth factor receptor 1 (VEGFR1) in the cornea.METHODS: Recombinant mouse (rm) VEGFR1 was incubated with various concentrations of recombinant MMP14 to examine proteolysis in vitr
• PMID 26284550

Japanese Journal

• 関節リウマチ患者に対するイグラチモド単剤投与の経験

• 臨床リウマチ 27(2), 100-105, 2015
• NAID 130005090302

• The combined effects of iguratimod with anti-TNFα antibody on experimental arthritis models in mice

• Inflammation and Regeneration 34(3), 157-164, 2014
• NAID 130004943861

• Yellow Wine Polyphenolic Compounds Inhibit Matrix Metalloproteinase-2, -9 Expression and Improve Atherosclerotic Plaque in LDL-Receptor–Knockout Mice

• Journal of Pharmacological Sciences 125(2), 132-141, 2014
• NAID 130004438629

Related Links

• Inhibition of matrix metalloproteinase 14 (MMP-14)-mediated ...

1. J Biol Chem. 2011 Sep 23;286(38):33167-77. doi: 10.1074/jbc.M111.256644. Epub 2011 Jul 27. Inhibition of matrix metalloproteinase 14 (MMP-14)-mediated cancer cell migration. Zarrabi K, Dufour A, Li J, Kuscu C ...

• MMP14 - Matrix metalloproteinase-14 precursor - Homo ...

Seems to specifically activate progelatinase A. May thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive ...

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★リンクテーブル★

リンク元	「MMP-14」「マトリックスメタロプロテアーゼ14」
関連記事	「matrix metalloproteinase」「metalloproteinase」「metalloproteinases」

「MMP-14」

　　[★]

• マトリックスメタロプロテアーゼ14

関

matrix metalloproteinase 14

「マトリックスメタロプロテアーゼ14」

　　[★]

英

matrix metalloproteinase 14、MMP-14

「matrix metalloproteinase」

　　[★] マトリックスメタロプロテアーゼ MMP

「metalloproteinase」

　　[★] メタロプロテアーゼ

「metalloproteinases」

　　[★] メタロプロテアーゼ