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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/09/01 16:50:34」(JST)
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English Journal
- Matrix metalloproteinase 7 is a useful marker for 5-fluorouracil-based adjuvant chemotherapy in stage II and stage III colorectal cancer patients.
- Huang Y, Yu H, Lei H, Xie C, Zhong Y.Author information Department of Radio-Chemo Therapy, Zhongnan Hospital, Wuhan University, Wuhan, Hubei, China.AbstractMatrix metalloproteinase 7 (MMP7) was reported to be a negative regulator in Fas-mediated apoptosis. The mechanism of cell killing associated with 5-FU treatment in colon cancer was also closely related to Fas-induced apoptosis, which implied that the expression level of MMP7 in colorectal cancer may be associated with the sensitivity of 5-FU treatment. To prove the hypothesis, first we verified the negative relevance between the colorectal cancer cells apoptosis in response to 5-FU treatment and MMP7 level by MTT and flow cytometry assay in vitro. Further, we found the apoptosis was in a positive relation with the Fas ligand level collected from the medium, suggesting a Fas-induced apoptosis. We found that increased level of MMP7 resulted in the enhanced drug resistance in SW620 colon cancer cells treated with 5-FU in vitro. Besides, we analyzed the influence of MMP7 on prognosis of 76 patients with TNM stage II-III colorectal cancers who had undergone curative resections and received 5-FU-based adjuvant chemotherapy. The expression of MMP7 was detected by IHC, and the relationship between the expression of MMP7 and disease-free survival was analyzed by univariate analysis and multivariate analysis. Patients with higher expression of MMP7 showed inferior disease-free survival (p = 0.007), and high expression of MMP7 was a significant independent unfavorable prognostic factor (p = 0.012). These data suggested that MMP7 is a useful marker for 5-FU chemotherapy sensitivity in patients with stage II-III colorectal cancer.
- Medical oncology (Northwood, London, England).Med Oncol.2014 Mar;31(3):824. doi: 10.1007/s12032-013-0824-0. Epub 2014 Jan 28.
- Matrix metalloproteinase 7 (MMP7) was reported to be a negative regulator in Fas-mediated apoptosis. The mechanism of cell killing associated with 5-FU treatment in colon cancer was also closely related to Fas-induced apoptosis, which implied that the expression level of MMP7 in colorectal cancer ma
- PMID 24469951
- Knockdown of MMP-7 inhibits cell proliferation and enhances sensitivity to 5-fluorouracil and X-ray irradiation in colon cancer cells.
- Zhang W, Li Y, Yang L, Zhou B, Chen KL, Meng WJ, Liu Y, Hu JK, Sun XF, Zhou ZG.Author information Department of Gastrointestinal Surgery, Institute of Digestive Surgery and Organ Microcirculation, West China Hospital, Sichuan University, No. 37 on Guo-Xue, Chengdu, 610041, Sichuan Provence, China.AbstractThe role of matrix metalloproteinase-7 (MMP-7) in the pathogenesis of colon cancer is not understood thoroughly. Previous studies from our group have shown that the expression levels of MMP-7 were highly elevated in colorectal cancer patient specimens and were correlated with Dukes Staging, histological differentiation grade and CEA level. The goal of this study was to investigate the cellular impact of MMP-7 in colon cancer. In this study, we used the SW480 colon cancer cell lines of MMP-7 knockdown by lentivirus-mediated RNA interference as a model system to investigate the impact of MMP-7 on cell proliferation and sensitivity to 5-Fluorouracil (5-FU) and X-ray irradiation (IR). Cell proliferation and sensitivity to 5-FU and IR were measured by MTT assay and colony formation assay. Cell cycle was evaluated by flow cytometry. We showed that the down regulation of MMP-7 inhibits colon cancer cell proliferation and sensitizes tumour cells to 5-FU and IR (P < 0.05). Decreased MMP-7 expression in SW480 cells by RNA interference triggered cell cycle arrest at G1 phase (P < 0.05). Down regulation of MMP-7 may inhibit the cell proliferation of colon cancer cells and increase tumour cells sensitivity to radiotherapy and chemotherapy. RNAi-mediated silencing of MMP-7 may represent a powerful therapeutic approach for controlling human colorectal cancer growth.
- Clinical and experimental medicine.Clin Exp Med.2014 Feb;14(1):99-106. doi: 10.1007/s10238-012-0212-7. Epub 2012 Oct 20.
- The role of matrix metalloproteinase-7 (MMP-7) in the pathogenesis of colon cancer is not understood thoroughly. Previous studies from our group have shown that the expression levels of MMP-7 were highly elevated in colorectal cancer patient specimens and were correlated with Dukes Staging, histolog
- PMID 23086188
- Fibulin-3 suppresses Wnt/β-catenin signaling and lung cancer invasion.
- Chen X, Meng J, Yue W, Yu J, Yang J, Yao Z, Zhang L.Author information Department of Immunology, Tianjin Key Laboratory of Cellular and Molecular Immunology, Key Laboratory of Immuno Microenviroment and Disease of the Educational Ministry, Tianjin Medical University, Tianjin, P.R. China.AbstractThe 5-year survival rate of lung cancer is below 20%, with most patients dying from distant metastasis. However, the molecular mechanisms underlying lung cancer invasion and metastasis have not been fully characterized. In this study, we found that fibulin-3, a fibulin family extracellular matrix protein, functions as a suppressor of lung cancer invasion and metastasis. Fibulin-3 was downregulated in large fractions of lung tumors and cell lines, and inhibited lung cancer cell invasion and the expression of matrix metalloproteinase-7 (MMP-7), a promoter of lung cancer invasion. The expression levels of fibulin-3 and MMP-7 were inversely correlated in lung tumors. Fibulin-3 inhibited extracellular signal-regulated kinase (ERK) to activate glycogen synthase kinase 3β (GSK3β) and suppress Wnt/β-catenin signaling, which induces MMP-7 expression in lung cancer cells. Furthermore, fibulin-3 expression impeded the growth and metastasis of lung tumors in mice. Collectively, these results suggest that downregulation of fibulin-3 contributes to lung cancer invasion and metastasis by activating Wnt/β-catenin signaling and MMP-7 expression.
- Carcinogenesis.Carcinogenesis.2014 Jan 30. [Epub ahead of print]
- The 5-year survival rate of lung cancer is below 20%, with most patients dying from distant metastasis. However, the molecular mechanisms underlying lung cancer invasion and metastasis have not been fully characterized. In this study, we found that fibulin-3, a fibulin family extracellular matrix pr
- PMID 24480807
Japanese Journal
- 活性型マトリックスメタロプロティナーゼ-7(マトリライシン-1)の局在解析のためのin situ zymographyの開発
- 根守 良一,山本 正義,片岡 史夫 [他]
- 富士フイルム研究報告 (52), 114-121, 2007
- NAID 40015365536
- Binding of active matrilysin to cell surface cholesterol sulfate is essential for its membrane-associated proteolytic action and induction of homotypic cell adhesion
- YAMAMOTO K
- J. Biol. Chem. 281, 9170-9180, 2006
- NAID 80019231491
- Matrilysin 1 influences colon carcinoma cell migration by cleavage of the laminin-5 beta3 chain
- REMY L
- Cancer Res 66, 11228-11237, 2006
- NAID 30018587147
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- P09237-1 []FASTA Add to basket Added to basket « Hide 10 20 30 40 50 MRLTVLCAVC LLPGSLALPL PQEAGGMSEL QWEQAQDYLK RFYLYDSETK ...
- Matrilysin-1 (also called matrix metalloproteinase-7) is expressed in injured lung and in cancer but not in normal epithelia. Bronchiolization of the alveoli (BOA), a potential precursor of lung cancer, is a histologically distinct type of ...
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「matrix metalloproteinase 7」
マトリックスメタロプロテアーゼ7、マトリックスメタロプロテイナーゼ7
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