- 関
- mannosylated
English Journal
- Neurons and Glia Modify Receptor Protein-tyrosine Phosphatase ζ (RPTPζ)/Phosphacan with Cell-specific O-Mannosyl Glycans in the Developing Brain.
- Dwyer CA1, Katoh T2, Tiemeyer M2, Matthews RT3.
- The Journal of biological chemistry.J Biol Chem.2015 Apr 17;290(16):10256-73. doi: 10.1074/jbc.M114.614099. Epub 2015 Mar 3.
- Protein O-mannosylation is a glycan modification that is required for normal nervous system development and function. Mutations in genes involved in protein O-mannosyl glycosylation give rise to a group of neurodevelopmental disorders known as congenital muscular dystrophies (CMDs) with associated C
- PMID 25737452
- Disease mutations in CMP-sialic acid transporter SLC35A1 result in abnormal α-dystroglycan O-mannosylation, independent from sialic acid.
- Riemersma M1, Sandrock J2, Boltje TJ3, Büll C4, Heise T3, Ashikov A2, Adema GJ4, van Bokhoven H5, Lefeber DJ6.
- Human molecular genetics.Hum Mol Genet.2015 Apr 15;24(8):2241-6. doi: 10.1093/hmg/ddu742. Epub 2014 Dec 30.
- Binding of cellular α-dystroglycan (α-DG) to its extracellular matrix ligands is fully dependent on a unique O-mannose-linked glycan. Disrupted O-mannosylation is the hallmark of the muscular dystrophy-dystroglycanopathy (MDDG) syndromes. SLC35A1, encoding the transporter of cytidine 5'-monophosph
- PMID 25552652
- Engineered Biosynthesis of Enduracidin Lipoglycopeptide Antibiotics using the Ramoplanin Mannosyltransferase Ram29.
- Wu MC1, Styles MQ1, Law BJ1, Struck AW1, Nunns L1, Micklefield J1.
- Microbiology (Reading, England).Microbiology.2015 Apr 15. pii: mic.0.000095. doi: 10.1099/mic.0.000095. [Epub ahead of print]
- The lipopeptides ramoplanin from Actinoplanes sp. ATCC 33076 and enduracidin produced by Streptomyces fungicidicus are effective antibiotics against a number of drug resistant Gram-positive pathogens. While these two antibiotics share a similar cyclic peptide structure, comprising 17 amino acids wit
- PMID 25878261
Japanese Journal
- タンパク質C-マンノシル化と予想されるその細胞機能
- Ihara Yoshito,Inai Yoko,Ikezaki Midori
- Trends in Glycoscience and Glycotechnology 23(129), 1-13, 2011
- タンパク質C-マンノシル (C-Man) 化はα-マンノースがC-C結合を介してトリプトファン (Trp/W) 残基のC2原子に直接結合している特徴的な糖付加修飾である。C-Man化はある種のタンパク質のTrp-x-x-Trp (W-x-x-W) というコンセンサス配列のはじめのTrp残基で主に観察される。この修飾反応は酵素によって触媒されるが、これを担うC-マンノース転移酵素は同定されていない。 …
- NAID 130000674611
- ENDO Tamao
- Trends in glycoscience and glycotechnology 22(125), 152-161, 2010-05-31
- 生体で作られるタンパク質の多くは糖鎖を含んでいる。糖鎖は糖タンパク質の生物学的な性質や機能に影響を与えることが知られている。糖タンパク質糖鎖は、タンパク質への結合様式によってN-型糖鎖とO-型糖鎖の二つのグループに大別される。本稿では、O-マンノース型糖鎖の構造、生合成、機能、そして病理との関連について概説する。
- NAID 10027508474
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- mannosylation Definition from Wiktionary, the free dictionary Jump to: navigation, search English [edit] Noun [edit] mannosylation (plural mannosylations) (biochemistry) The formation of a mannose glycoside, especially one of a protein or ...
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- mannosylation、mannosylated