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1. 発作性夜間血色素尿症の病因：GPIアンカーの欠如 pathogenesis of paroxysmal nocturnal hemoglobinuria absence of the gpi anchor
2. マンノース結合レクチン欠損症 mannose binding lectin deficiency

English Journal

Mycobacterium tuberculosis promotes Th17 expansion via regulation of human dendritic cells toward a high CD14 and low IL-12p70 phenotype that reprograms upon exogenous IFN-γ.

Søndergaard JN1, Laursen JM2, Rosholm LB2, Brix S3.
International immunology.Int Immunol.2014 Dec;26(12):705-16. doi: 10.1093/intimm/dxu085. Epub 2014 Sep 15.
The capacity to develop protective immunity against mycobacteria is heterogeneously distributed among human beings, and it is currently unknown why the initial immune response induced against Mycobacterium tuberculosis (Mtb) does not provide proper clearance of this pathogen. Dendritic cells (DCs) a
PMID 25223368

Effect of space length of mannose ligand on uptake of mannosylated liposome in RAW 264.7 cells: In vitro and in vivo studies.

Jeong HS1, Sook Na K, Hwang H, Oh PS, Hyun Kim D, Tae Lim S, Sohn MH, Jeong HJ.
Journal of biomedical materials research. Part A.J Biomed Mater Res A.2014 Dec;102(12):4545-53. doi: 10.1002/jbm.a.35112. Epub 2014 Mar 2.
The most widely used method for increasing uptake on macrophage is specific targeting for mannose receptor (MR) presented on macrophages. Efficiency of the uptake for MR is influenced by the space length and flexibility of mannose ligand in liposome (LP). We prepared mannosylated liposomes (M-EGn-LP
PMID 24677479

Optimal structural design of mannosylated nanocarriers for macrophage targeting.

Chen P1, Zhang X2, Jia L3, Prud'homme RK4, Szekely Z5, Sinko PJ6.
Journal of controlled release : official journal of the Controlled Release Society.J Control Release.2014 Nov 28;194:341-9. doi: 10.1016/j.jconrel.2014.09.006. Epub 2014 Sep 16.
Macrophages are involved in a number of diseases, such as HIV infection/AIDS, tuberculosis, tumor development and atherosclerosis. Macrophages possess several cell surface receptors (e.g., the mannose receptor, MR) that may serve as drug delivery cellular portals for nanocarriers (NCs). In this stud
PMID 25220160

森本一洋
YAKUGAKU ZASSHI 133(1), 81-92, 2013
… Furthermore, the drug delivery efficacy of mannosylated CPFX-liposome (particle size: 1000 nm) was highly delivered to AM and antibacterial effects were significantly higher than those of unmodified CPFX-liposome. …
NAID 130003361891

Ihara Yoshito,Inai Yoko,Ikezaki Midori
Trends in glycoscience and glycotechnology 23(129), 1-13, 2011-05-31
タンパク質C-マンノシル (C-Man) 化はα-マンノースがC-C結合を介してトリプトファン (Trp/W) 残基のC2原子に直接結合している特徴的な糖付加修飾である。C-Man化はある種のタンパク質のTrp-x-x-Trp (W-x-x-W) というコンセンサス配列のはじめのTrp残基で主に観察される。この修飾反応は酵素によって触媒されるが、これを担うC-マンノース転移酵素は同定されていない。 …
NAID 10029582397

Evaluation of osteoclastogenesis via NFκB decoy/mannosylated cationic liposome-mediated inhibition of pro-inflammatory cytokine production from primary cultured macrophages.

Dinh Thuy Duong,Higuchi Yuriko,Kawakami Shigeru,Yamashita Fumiyoshi,Hashida Mitsuru
Pharmaceutical research 28(4), 742-751, 2011-04
To explore the effect of NFκB activation in macrophages on osteoclastogenesis of bone marrow cells for potential application as a new type of therapy for preventing bone loss.
NAID 120003072110