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Physicochemical and pharmacokinetic characterization of a spray-dried malotilate emulsion.

Zhang J, Gao Y, Qian S, Liu X, Zu H.SourceSchool of Pharmacy, China Pharmaceutical University, Nanjing 210009, PR China.
International journal of pharmaceutics.Int J Pharm.2011 Jul 29;414(1-2):186-92. doi: 10.1016/j.ijpharm.2011.05.032. Epub 2011 May 17.
Malotilate (MT) is a hepatoprotective drug administered orally. However, MT was found to be a poorly water-soluble drug with low oral bioavailability. In the present investigation, a novel spray-dried emulsion (SDE) loaded with MT was prepared, and its physicochemical properties were characterized b
PMID 21619915

Serum levels of YKL-40 and PIIINP as prognostic markers in patients with alcoholic liver disease.

Nøjgaard C, Johansen JS, Christensen E, Skovgaard LT, Price PA, Becker U; EMALD Group.SourceDepartment of Gastroenterology and Alcohol Unit, Hvidovre Hospital, Hvidovre, Denmark. mille@dadlnet.dk
Journal of hepatology.J Hepatol.2003 Aug;39(2):179-86.
BACKGROUND/AIMS: YKL-40 (growth factor) and PIIINP (N-terminal propeptide of Type III procollagen) are potential markers of liver fibrosis. The aim was to evaluate the prognostic value of serum YKL-40 and PIIINP levels in patients with alcoholic liver disease.METHODS: Three hundred and seventy patie
PMID 12873813

[Establishment of BCG combined LPS-induced hepatocyte immunotoxicity model to assess liver protective effects]

Zheng QZ, Wang LM, Lou YJ.SourceCollege of Pharmacy, Zhejiang University, Hangzhou 310031, China.
Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences.Zhejiang Da Xue Xue Bao Yi Xue Ban.2002 Aug;31(6):419-423.
OBJECTIVE: To establish a hepatocyte immunotoxicity model for screening of liver protective medications.METHODS: Cytotoxicity was induced by coincubating BCG-pretreated rat hepatocytes in vivo and with 10 mg/L LPS in vitro. Biphenyldimethylesterate (DDB), malotilate(MLT), silybin(SB) and glycyrrhizi
PMID 12601856

Inhibitory effects of malotilate on in vitro invasion of lung′ endothelial cell monolayer by human oral squamous cell′ carcinoma cells.

Shibta T.,Nagayasu H.,Hamada J-I.,Konaka S.,′ Hosokawa M.,Kawano T.,Kitajo H.,Arisue M.
Collected papers from Institute for Genetic Medicine Hokkaido University 2, 185-194, 2001
NAID 110000091074

Fibroblast-migration in a wound model of ascorbic acid-supplemented three-dimensional culture system : the effects of cytokines and malotilate, a new wound healing stimulant, on cell-migration

OHGODA Osamu,SAKAI Atsushi,KOGA Hiroyasu,KANAI Kazuo,MIYAZAKI Tsuneo,NIWANO Yoshimi
Journal of dermatological science 17(2), 123-131, 1998-06-01
NAID 10017051459

Pharmacokinetics of Malotilate in Compensated or Decompensated Cirrhotic Patients.

伯水英夫,中岡稔,鈴木亘,五十嵐省吾
臨床薬理 24(3), 497-508, 1993
… Malotilate, an agent used for the treatment of liver disease, is extensively metabolized; … the pharmacokinetic profile of malotilate is ready altered in patients with liver diseases. … The differences in pharmacokinetic profiles of malotilate between compensatory and noncompensatory liver cirrhosis patients were estimated. …
NAID 130002045513

リンク元

Malotilate
Systematic (IUPAC) name
	diisopropyl 1,3-dithiol-2-ylidenemalonate
Clinical data
AHFS/Drugs.com	International Drug Names
Routes of; administration	Oral
Legal status
Legal status	℞ (Prescription only);
Identifiers
CAS Number	59937-28-9
ATC code	none
PubChem	CID 4006
ChemSpider	3866
UNII	RV59PND975
ChEMBL	CHEMBL1697754
Chemical data
Formula	C12H16O4S2
Molar mass	288.38 g/mol
	SMILES CC(C)OC(=O)C(=C1SC=CS1)C(=O)OC(C)C ;
	InChI InChI=1S/C12H16O4S2/c1-7(2)15-10(13)9(11(14)16-8(3)4)12-17-5-6-18-12/h5-8H,1-4H3 ; Key:YPIQVCUJEKAZCP-UHFFFAOYSA-N ;
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