出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/01/19 03:48:12」(JST)
| Magnesium stearate | |
|---|---|
|
IUPAC name
Magnesium octadecanoate |
|
| Identifiers | |
| CAS number | 557-04-0 Y |
| PubChem | 11177 |
| ChemSpider | 10704 Y {CH} |
| UNII | 70097M6I30 Y |
| ChEBI | CHEBI:9254 Y |
| Jmol-3D images | Image 1 |
|
SMILES
|
|
|
InChI
|
|
| Properties | |
| Molecular formula | Mg(C 18H |
| Molar mass | 591.27 g/mol |
| Appearance | light white powder |
| Odor | slight |
| Density | 1.026 g/cm3 |
| Melting point | 88.5 °C (191.3 °F; 361.6 K) |
| Solubility in water | 0.003 g/100 mL (15 °C) 0.004 g/100 mL (25 °C) |
| Solubility | negligible in ether and alcohol slightly soluble in benzene |
| Hazards | |
| MSDS | External MSDS |
| NFPA 704 |
1
1
0
|
| Flash point | 250 °C (482 °F; 523 K) |
| LD50 | > 1000 mg/kg (oral, rat) |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa) | |
| Y (verify) (what is: Y/N?) | |
| Infobox references | |
Magnesium stearate, also called octadecanoic acid, magnesium salt, is a white substance, powder which becomes solid at room temperature. It has the chemical formula Mg(C
18H
35O
2)
2. It is a salt containing two equivalents of stearate (the anion of stearic acid) and one magnesium cation (Mg2+). Magnesium stearate melts at about 88 °C, is not soluble in water, and is generally considered safe for human consumption at levels below 2500 mg/kg per day.[1] In 1979, the FDA's Subcommittee on GRAS (generally recognized as safe) Substances (SCOGS) reported, "There is no evidence in the available information on ... magnesium stearate ... that demonstrates, or suggests reasonable grounds to suspect, a hazard to the public when they are used at levels that are now current and in the manner now practiced, or which might reasonably be expected in the future."[2]
Magnesium stearate is created by the reaction of sodium stearate with magnesium sulfate.
Magnesium stearate is often used as an anti-adherent[3] in the manufacture of medical tablets, capsules and powders.[4] In this regard, the substance is also useful, because it has lubricating properties, preventing ingredients from sticking to manufacturing equipment during the compression of chemical powders into solid tablets; magnesium stearate is the most commonly used lubricant for tablets.[5] Studies have shown that magnesium stearate may affect the release time of the active ingredients in tablets, etc., but not that it reduces the overall bioavailability of those ingredients.[6][7] As a food additive or pharmaceutical excipient, its E number is E470b.
Magnesium stearate is also used to bind sugar in hard candies like mints, and is a common ingredient in baby formulas. In pure powder form, the substance can be a dust explosion hazard, although this issue is effectively insignificant beyond the manufacturing plants using it.[8]
Magnesium stearate is manufactured from both animal and vegetable oils. Some nutritional supplements specify that the magnesium stearate used is sourced from vegetables.[citation needed]
Magnesium stearate is a major component of "bathtub rings." When produced by soap and hard water, magnesium stearate and calcium stearate both form a white solid insoluble in water, and are collectively known as "soap scum."[9]
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
| リンク元 | 「aluminum monostearate」「ステアリン酸マグネシウム」「calcium stearate」「octadecanoic acid」 |
| 関連記事 | 「stearate」「magnesium」 |