マガルドレート
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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/06/21 19:07:38」(JST)
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Magaldrate
|
Systematic (IUPAC) name |
Magnesium aluminate monohydrate |
Clinical data |
AHFS/Drugs.com |
Micromedex Detailed Consumer Information |
MedlinePlus |
a682683 |
Pregnancy
category
|
|
Legal status
|
|
Routes of
administration
|
Oral |
Pharmacokinetic data |
Bioavailability |
Negligible |
Metabolism |
Nil |
Excretion |
Fecal and renal |
Identifiers |
CAS Registry Number
|
1317-26-6 Y |
ATC code
|
A02AD02
A02AF01 (combination with antiflatulents) |
PubChem |
CID: 6336542 |
ChemSpider |
4891688 Y |
UNII |
6V88E24N5T Y |
Chemical data |
Formula |
AlMg2(OH)7·H2O |
Molecular mass
|
212.66 g/mol |
InChI
-
InChI=1S/Al.Mg.2H2O/h;;2*1H2/p-1 Y
Key:SXSTVPXRZQQBKQ-UHFFFAOYSA-M Y
|
Y (what is this?) (verify) |
Magaldrate (INN) is a common antacid drug that is used for the treatment of duodenal and gastric ulcers, esophagitis from gastroesophageal reflux.
Contents
- 1 Available forms
- 2 Pharmacology
- 3 Interactions and adverse reactions
- 4 Brand names
- 5 References
Available forms
Magaldrate is available in the form of oral suspension or tablets.
Pharmacology
Magaldrate is a hydroxymagnesium aluminate complex that is converted rapidly in gastric acid to Mg(OH)2 and Al(OH)3, which are absorbed poorly and thus provide a sustained antacid effect.[1]
Interactions and adverse reactions
Magaldrate may negatively influence drugs like tetracyclines, benzodiazepines, and indomethacin. High doses or prolonged usage may lead to an increment of defecation and a reduction in feces consistence. In some cases it can alter the functionality of the gastrointestinal tract, occasionally provoking constipation or diarrhea.
Brand names
The drug is sold with the following brand names:Maganta plus (Square pharma,Bangladesh) Digecid Plus (Beximco Pharma, Bangladesh), Marlox Plus (Incepta pharma Bangladesh), Gastid (SK+F, Bangladesh), Novelta (Bangladesh), Gadral (Italy); Magaltop (Italy); Magralibi (Italy); Mylanta (Australia); Riopan (Argentina, Austria, Brazil, Egypt, Germany, Italy, Mexico, Belgium, Switzerland, Greece).
References
|
This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed. (September 2014) |
- ^ Laurence L., Brunton. Goodman & Gilman's The Pharmacological Basis of Therapeutics, 12th ed.
Drugs for acid related disorders: Antacids (A02A)
|
|
Magnesium
(increases motility) |
- Magnesium carbonate
- Magnesium oxide
- Magnesium peroxide
- Magnesium hydroxide
- Magnesium silicate
|
|
Aluminium
(decreases motility) |
- Algeldrate
- Aluminium phosphate
- Aluminium acetoacetate
- Aloglutamol
- Aluminium glycinate
- Carbaldrate
|
|
Calcium |
- Calcium carbonate
- Calcium silicate
|
|
Sodium |
|
|
Combinations and complexes
of aluminium, calcium and magnesium |
- Almagate
- Almasilate
- Hydrotalcite
- Magaldrate
|
|
Index of digestion
|
|
Description |
- Anatomy
- Physiology
- Development
|
|
Disease |
- Congenital
- Neoplasms and cancer
- Inflammatory bowel disease
- Gluten sensitivity
- Other
- Symptoms and signs
- Blood tests
|
|
Treatment |
- Procedures
- Drugs
- anabolic steroids
- antacids
- diarrhoea and infection
- bile and liver
- functional gastrointestinal disorders
- laxatives
- peptic ulcer and reflux
- nausea and vomiting
- other
- Surgery
|
|
|
English Journal
- Acute pericarditis and myocarditis by Toxoplasma gondii in an immunocompetent young man: a case report.
- Pergola G, Cascone A, Russo M.SourceDepartment of Infectious Diseases, Second University of Naples, Italy.
- Le infezioni in medicina : rivista periodica di eziologia, epidemiologia, diagnostica, clinica e terapia delle patologie infettive.Infez Med.2010 Mar;18(1):48-52.
- Infection due to protozoan parasite Toxoplasma gondii is highly prevalent among humans throughout the world. Acquired primary infection is seldom severe in immunocompetent people while it can be life-threatening in immunodeficient ones. We report a case of acquired toxoplasmosis in an immunocompeten
- PMID 20424527
- Cephradine antacids interaction studies.
- Arayne MS, Sultana N, Afzal M.SourceDepartment of Chemistry, University of Karachi, Karachi-75270, Pakistan. arayne@gawab.com
- Pakistan journal of pharmaceutical sciences.Pak J Pharm Sci.2007 Jul;20(3):179-84.
- The present work comprises of interaction studies of cephradine with antacids. Cephradine is included among the first generation cephalosporin, which is active against a wide range of Gram positive and Gram-negative bacteria including penicillinase-producing staphylococci. Since the presence of comp
- PMID 17545100
Related Links
- magaldrate /mag·al·drate/ (mag´al-drāt) a chemical combination of aluminum and magnesium hydroxides and sulfate; an antacid. magaldrate [mag′əldrāte] an antacid containing a combination of magnesium and aluminum compounds. ...
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