magaldrate

Magaldrate
Systematic (IUPAC) name
	Magnesium aluminate monohydrate
Clinical data
AHFS/Drugs.com	Micromedex Detailed Consumer Information
MedlinePlus	a682683
Pregnancy; category	C;
Legal status	OTC;
Routes of; administration	Oral
Pharmacokinetic data
Bioavailability	Negligible
Metabolism	Nil
Excretion	Fecal and renal
Identifiers
CAS Registry Number	1317-26-6
ATC code	A02AD02; A02AF01 (combination with antiflatulents)
PubChem	CID: 6336542
ChemSpider	4891688
UNII	6V88E24N5T
Chemical data
Formula	AlMg2(OH)7·H2O
Molecular mass	212.66 g/mol
	InChI InChI=1S/Al.Mg.2H2O/h;;2*1H2/p-1 ; Key:SXSTVPXRZQQBKQ-UHFFFAOYSA-M ;
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マガルドレート

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/06/21 19:07:38」(JST)

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Magaldrate (INN) is a common antacid drug that is used for the treatment of duodenal and gastric ulcers, esophagitis from gastroesophageal reflux.

Available forms

Magaldrate is available in the form of oral suspension or tablets.

Pharmacology

Magaldrate is a hydroxymagnesium aluminate complex that is converted rapidly in gastric acid to Mg(OH)₂ and Al(OH)₃, which are absorbed poorly and thus provide a sustained antacid effect.^[1]

Interactions and adverse reactions

Magaldrate may negatively influence drugs like tetracyclines, benzodiazepines, and indomethacin. High doses or prolonged usage may lead to an increment of defecation and a reduction in feces consistence. In some cases it can alter the functionality of the gastrointestinal tract, occasionally provoking constipation or diarrhea.

Brand names

The drug is sold with the following brand names:Maganta plus (Square pharma,Bangladesh) Digecid Plus (Beximco Pharma, Bangladesh), Marlox Plus (Incepta pharma Bangladesh), Gastid (SK+F, Bangladesh), Novelta (Bangladesh), Gadral (Italy); Magaltop (Italy); Magralibi (Italy); Mylanta (Australia); Riopan (Argentina, Austria, Brazil, Egypt, Germany, Italy, Mexico, Belgium, Switzerland, Greece).

References

^ Laurence L., Brunton. Goodman & Gilman's The Pharmacological Basis of Therapeutics, 12th ed.

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English Journal

Acute pericarditis and myocarditis by Toxoplasma gondii in an immunocompetent young man: a case report.

Pergola G, Cascone A, Russo M.SourceDepartment of Infectious Diseases, Second University of Naples, Italy.
Le infezioni in medicina : rivista periodica di eziologia, epidemiologia, diagnostica, clinica e terapia delle patologie infettive.Infez Med.2010 Mar;18(1):48-52.
Infection due to protozoan parasite Toxoplasma gondii is highly prevalent among humans throughout the world. Acquired primary infection is seldom severe in immunocompetent people while it can be life-threatening in immunodeficient ones. We report a case of acquired toxoplasmosis in an immunocompeten
PMID 20424527

Cephradine antacids interaction studies.

Arayne MS, Sultana N, Afzal M.SourceDepartment of Chemistry, University of Karachi, Karachi-75270, Pakistan. arayne@gawab.com
Pakistan journal of pharmaceutical sciences.Pak J Pharm Sci.2007 Jul;20(3):179-84.
The present work comprises of interaction studies of cephradine with antacids. Cephradine is included among the first generation cephalosporin, which is active against a wide range of Gram positive and Gram-negative bacteria including penicillinase-producing staphylococci. Since the presence of comp
PMID 17545100