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1. β-ラクタム系抗生物質：作用機序、耐性および有害作用 beta lactam antibiotics mechanisms of action and resistance and adverse effects
2. β-ラクタム系抗菌薬に対する肺炎レンサ球菌の耐性 resistance of streptococcus pneumoniae to beta lactam antibiotics
3. 成人における市中肺炎の治療に関する抗菌薬の研究 antibiotic studies for the treatment of community acquired pneumonia in adults
4. 腸球菌における抗菌薬耐性の機構 mechanisms of antibiotic resistance in enterococci
5. 基質特異性拡張型β-ラクタマーゼ extended spectrum beta lactamases

English Journal

David N1, Pasceri R1, Kitson RR1, Pradal A1, Moody CJ2.
Chemistry (Weinheim an der Bergstrasse, Germany).Chemistry.2016 Jul 25;22(31):10867-76. doi: 10.1002/chem.201601605. Epub 2016 Jun 27.
A short formal total synthesis of the marine natural product diazonamide A is described. The route is based on indole oxidative rearrangement, and a number of options were investigated involving migration of tyrosine or oxazole fragments upon oxidation of open chain or macrocyclic precursors. The
PMID 27346186

Acquired resistance to HSP90 inhibitor 17-AAG and increased metastatic potential are associated with MUC1 expression in colon carcinoma cells.

Liu X1, Ban LL, Luo G, Li ZY, Li YF, Zhou YC, Wang XC, Jin CG, Ye JG, Ma DD, Xie Q, Huang YG.
Anti-cancer drugs.Anticancer Drugs.2016 Jun;27(5):417-26. doi: 10.1097/CAD.0000000000000347.
Heat shock protein 90 (HSP90) is a molecular chaperone required for the stability and function of many proteins. The chaperoning of oncoproteins by HSP90 enhances the survival, growth, and invasive potential of cancer cells. HSP90 inhibitors are promising new anticancer agents, in which the benzoqui
PMID 26872308

[Gene Expression Profile of Apoptosis in Leukemia Cells Induced by Hsp90 Selective inhibitor 17-AAG].

Wang NN1, Li ZH1, Tao YF1, Xu LX1, Pan J1, Hu SY2.
Zhongguo shi yan xue ye xue za zhi / Zhongguo bing li sheng li xue hui = Journal of experimental hematology / Chinese Association of Pathophysiology.Zhongguo Shi Yan Xue Ye Xue Za Zhi.2016 Jun;24(3):672-80. doi: 10.7534/j.issn.1009-2137.2016.03.007.
OBJECTIVE: To investigate the apoptotic effects of Hsp90 selective inhibitor 17-AAG on human leukemia HL-60 and NB4 cells and analyse its possible mechanism.METHODS: CCK-8 assay was used to quantify the growth inhibition of cells after exposure to 17-AAG for 24 hours. Flow cytometrve with annexin V/
PMID 27342489

Heterocycles : an international journal for reviews and communications in heterocyclic chemistry 91(4), 701-717, 2015-04-01
NAID 40020423179

Identification of micromonolactam, a new polyene macrocyclic lactam from two marine Micromonospora strains using chemical and molecular methods : clarification of the biosynthetic pathway from a glutamate starter unit