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metabotropic glutamate receptor
Metabotropic glutamate receptors

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/04/05 04:16:23」(JST)

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  • Epileptic stimulus increases Homer 1a expression to modulate endocannabinoid signaling in cultured hippocampal neurons.
  • Li Y, Krogh KA, Thayer SA.SourceDepartment of Pharmacology, University of Minnesota Medical School, 6-120 Jackson Hall, 321 Church Street, Minneapolis, MN 55455, USA.
  • Neuropharmacology.Neuropharmacology.2012 Nov;63(6):1140-9. Epub 2012 Jul 16.
  • Endocannabinoid (eCB) signaling serves as an on-demand neuroprotective system. eCBs are produced postsynaptically in response to depolarization or activation of metabotropic glutamate receptors (mGluRs) and act on presynaptic cannabinoid receptor-1 to suppress synaptic transmission. Here, we examine
  • PMID 22814532
  • β-Estradiol unmasks metabotropic receptor-mediated metaplasticity of NMDA receptor transmission in the female rat dentate gyrus.
  • Nebieridze N, Zhang XL, Chachua T, Velíšek L, Stanton PK, Velíšková J.SourceDepartment of Cell Biology & Anatomy, New York Medical College, Valhalla, NY, USA.
  • Psychoneuroendocrinology.Psychoneuroendocrinology.2012 Nov;37(11):1845-54. doi: 10.1016/j.psyneuen.2012.03.023. Epub 2012 Apr 27.
  • Loss of estrogen in women following menopause is associated with increased risk for cognitive decline, dementia and depression, all of which can be prevented by estradiol replacement. The dentate gyrus plays an important role in cognition, learning and memory. The gatekeeping function of the dentate
  • PMID 22541715


  • Ca(2+)-dependent binding of calcium-binding protein 1 to presynaptic group III metabotropic glutamate receptors and blockage by phosphorylation of the receptors.
  • Nakajima Yoshiaki
  • Biochemical and biophysical research communications 412(4), 602-605, 2011-09-09
  • Presynaptic group III metabotropic glutamate receptors (mGluRs) and Ca(2+) channels are the main neuronal activity-dependent regulators of synaptic vesicle release, and they use common molecules in th …
  • NAID 80021990000
  • 神経系前駆細胞における機能的グルタミン酸シグナリング
  • 中道 範隆
  • 薬学雑誌 131(9), 1311-1316, 2011
  • … In this review, we have summarized our recent studies on the functionality of ionotropic (iGluR) and metabotropic (mGluR) glutamate receptors expressed by undifferentiated neural progenitor cells (NPC) isolated from embryonic rat and mouse brains. … Reverse transcription polymerase chain reaction analyses revealed expression of mRNA for particular iGluR and mGluR subtypes in NPC. …
  • NAID 40018967174


mGluRに対する薬剤の作用部位としての活性化スイッチ 本研究で同定された活性化スイッチを担う残基のうち、ヘリックスⅢのチロシン残基はmGluRの活性を制御する薬剤(MPEP, EM-TBPC)の結合部位のひとつとして過去に報告されている ...
代謝型グルタミン酸受容体(mGluR) タンパク質を構成するアミノ酸の1種であるグルタミン酸は、神経伝達物質としての作用があります。グルタミン酸を受容するグルタミン酸受容体は、イオンチャネル型受容体と代謝型受容体に分類 ...



リンク元代謝型グルタミン酸受容体」「metabotropic glutamate receptor」「代謝型グルタミン酸レセプター



metabotropic glutamate receptormGluR
Metabotropic glutamate receptors

metabotropic glutamate receptor」





metabotropic glutamate receptormGluR

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