リソソーム膜糖タンパク質
WordNet
- having partial rights and privileges or subordinate status; "an associate member"; "an associate professor"
- a person who joins with others in some activity or endeavor; "he had to consult his associate before continuing"
- a person with subordinate membership in a society, institution, or commercial enterprise; "associates in the law firm bill at a lower rate than do partners"
- any event that usually accompanies or is closely connected with another; "first was the lightning and then its thunderous associate"
- make a logical or causal connection; "I cannot connect these two pieces of evidence in my mind"; "colligate these facts"; "I cannot relate these events at all" (同)tie_in, relate, link, colligate, link up, connect
- a thin pliable sheet of material
- a pliable sheet of tissue that covers or lines or connects the organs or cells of animals or plants (同)tissue layer
- an organelle found in the cytoplasm of most cells (especially in leukocytes and liver and kidney cells)
- a conjugated protein having a carbohydrate component
PrepTutorEJDIC
- 〈人〉'を'(…の)『仲間に加える』,(…に)連合させる《+『名』〈人〉+『with』+『名』》 / (…と)…'を'結びつけて考える(起こす)《+『名』+『with』+『名』》 / (…と)『仲間になる』,交際する《+『with』+『名』》 / (…と)合体する,提携する《+『with』+『名』》 / 『仲間』,『同僚』;組合員 / 準会員 / 付属物;連想されるもの / 連合した;仲間の,同僚の / 補助の,準…
- (生物の)膜,皮膜
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/11/07 17:57:31」(JST)
[Wiki en表示]
| Lysosome-associated membrane glycoprotein (Lamp) |
| Identifiers |
| Symbol |
Lamp |
| Pfam |
PF01299 |
| InterPro |
IPR002000 |
| PROSITE |
PDOC00280 |
| TCDB |
9.A.16 |
| Available protein structures: |
| Pfam |
structures |
| PDB |
RCSB PDB; PDBe; PDBj |
| PDBsum |
structure summary |
|
Lysosome-associated membrane glycoproteins (lamp)[1] are integral membrane proteins, specific to lysosomes, and whose exact biological function is not yet clear. Structurally, the lamp proteins consist of two internally homologous lysosome-luminal domains separated by a proline-rich hinge region; at the C-terminal extremity there is a transmembrane region (TM) followed by a very short cytoplasmic tail (C). In each of the duplicated domains, there are two conserved disulfide bonds. This structure is schematically represented in the figure below.
+-----+ +-----+ +-----+ +-----+
| | | | | | | |
xCxxxxxCxxxxxxxxxxxxCxxxxxCxxxxxxxxxCxxxxxCxxxxxxxxxxxxCxxxxxCxxxxxxxx
+--------------------------++Hinge++--------------------------++TM++C+
In mammals, there are two closely related types of lamp: LAMP1 and LAMP2.
CD69 (also called gp110 or macrosialin)[2] is a heavily glycosylated integral membrane protein whose structure consists of a mucin-like domain followed by a proline-rich hinge; a single lamp-like domain; a transmembrane region and a short cytoplasmic tail.
CD molecules are leucocyte antigens on cell surfaces. CD antigens nomenclature is updated at Protein Reviews On The Web (http://mpr.nci.nih.gov/prow/).
Human proteins containing this domain[edit]
CD68; LAMP1; LAMP2; LAMP3;
References[edit]
- ^ Fukuda M (1991). "Lysosomal membrane glycoproteins. Structure, biosynthesis, and intracellular trafficking". J. Biol. Chem. 266 (32): 21327–21330. PMID 1939168.
- ^ Holness CL, da Silva RP, Fawcett J, Gordon S, Simmons DL (1993). "Macrosialin, a mouse macrophage-restricted glycoprotein, is a member of the lamp/lgp family". J. Biol. Chem. 268 (13): 9661–9666. PMID 8486654.
|
Peroxisomal and lysosomal proteins
|
|
| Enzymes |
Mevalonate kinase · Catalase · Acetyl-CoA C-acyltransferase · Glyceronephosphate O-acyltransferase · Alkylglycerone phosphate synthase · Phytanoyl-CoA hydroxylase · HSD17B4 · AMACR
|
|
| Transporters |
SLC27A2
|
|
| Structure/Peroxin |
PEX1, PEX2 - PXMP3, PEX3, PEX5, PEX6, PEX7, PEX10, PEX11A, PEX11B, PEX11G, PEX12, PEX13, PEX14, PEX16, PEX19, PEX26
|
|
| LAMP |
CD68 · LAMP1 · LAMP2 · LAMP3
|
|
|
see also intermediates, disorders
B strc: edmb (perx), skel (ctrs), epit, cili, mito, nucl (chro)
|
|
This article incorporates text from the public domain Pfam and InterPro IPR002000
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
English Journal
- Construction and evaluation of DNA vaccine encoding Hantavirus glycoprotein N-terminal fused with lysosome-associated membrane protein.
- Jiang DB1, Sun YJ2, Cheng LF3, Zhang GF1, Dong C4, Jin BQ2, Song CJ2, Ma Y2, Zhang FL5, Yang K6.
- Vaccine.Vaccine.2015 Jun 26;33(29):3367-76. doi: 10.1016/j.vaccine.2015.05.007. Epub 2015 May 28.
- BACKGROUND: Hantaviral diseases can have a high case fatality rate within the absence of broadly effective antiviral treatments or vaccines. We developed a DNA vaccine targeting the Hantavirus glycoprotein N-terminal (Gn) to major histocompatibility complex class II compartment by fusing the antigen
- PMID 26027907
- Micellar extraction possesses a new advantage for the analysis of Alzheimer's disease brain proteome.
- Musunuri S1, Kultima K, Richard BC, Ingelsson M, Lannfelt L, Bergquist J, Shevchenko G.
- Analytical and bioanalytical chemistry.Anal Bioanal Chem.2015 Feb;407(4):1041-57. doi: 10.1007/s00216-014-8320-8. Epub 2014 Nov 22.
- Integral membrane proteins (MPs), such as transporters, receptors, and ion channels, are of great interest because of their participation in various vital cellular functions including cell-cell interactions, ion transport, and signal transduction. However, studies of MPs are complicated because of t
- PMID 25416231
- Lysosome-associated membrane proteins (LAMPs) regulate intracellular positioning of mitochondria in MC3T3-E1 cells.
- Rajapakshe AR1, Podyma-Inoue KA1, Terasawa K1, Hasegawa K2, Namba T1, Kumei Y1, Yanagishita M1, Hara-Yokoyama M3.
- Experimental cell research.Exp Cell Res.2015 Feb 1;331(1):211-22. doi: 10.1016/j.yexcr.2014.09.014. Epub 2014 Sep 22.
- The intracellular positioning of both lysosomes and mitochondria meets the requirements of degradation and energy supply, which are respectively the two major functions for cellular maintenance. The positioning of both lysosomes and mitochondria is apparently affected by the nutrient status of the c
- PMID 25246127
Japanese Journal
- The Major Lysosomal Membrane Proteins LAMP-1 and LAMP-2 Participate in Differentiation of C2C12 Myoblasts
- N-acetylglucosaminyltransferase IVa promotes invasion of choriocarcinoma
- Constitutive expression of a COOH-terminal leucine mutant of lysosome-associated membrane protein-1 causes its exclusive localization in low density intracellular vesicles
Related Links
- Lysosome-associated membrane glycoproteins (lamp) [PMID: 1939168] are integral membrane proteins, specific to lysosomes, and whose exact biological function is not yet clear. Structurally, the lamp proteins consist of two ...
- Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis. ... 100% UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry. 90% UniRef90 ...
★リンクテーブル★
[★]
- 関
- LAMP、lysosome-associated membrane glycoprotein
[★]
- 英
- lysosome-associated membrane glycoprotein
- 関
- リソソーム膜タンパク質
[★]
- 結合する、連合させる。連想によって結びつける。(人を)仲間/友達などとしての関係に置く。(化)会合させる
- 仲間/友人などとして交際する(with)。一つにまとめる、連合する
- 仕事仲間、提携者、同僚。友人、朋友。準会員。従業員、社員
- 密接な蒸す偽付きのある物、付随する物、つきもの。準国家
- 連想によって心に浮かぶ言葉/思い、連想物
- 仲間の、同僚の。製紙機械員に次ぐ資格の
- 付随する、連想される
- 関
- accompany、association、associative、attach、bearing、bind、binding、bond、bonding、coassemble、colleague、combine、conjoin、conjugate、conjugation、conjunction、connect、connection、correlate、correlation、couple、dock、engage、engagement、federation、implication、join、joint、ligate、link、linkage、peer、pertinent、reference、relate、relation、relationship、relative、relevance、relevant、symphysial、union
[★]
- 関
- concomitant、erratic、erratically
- associate
[★]
- 関
- cell surface glycoprotein、surface glycoprotein
[★]