lysosomal enzymes

出典: meddic

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/07/31 04:13:14」(JST)

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  • Three dimensional structure of a bacterial α-l-fucosidase with a 5-membered iminocyclitol inhibitor.
  • Wright DW, Moreno-Vargas AJ, Carmona AT, Robina I, Davies GJ.SourceStructural Biology Laboratory, Department of Chemistry, University of York, York YO10 5DD, United Kingdom.
  • Bioorganic & medicinal chemistry.Bioorg Med Chem.2013 Aug 15;21(16):4751-4. doi: 10.1016/j.bmc.2013.05.056. Epub 2013 Jun 13.
  • Fucosidases, enzymes that cleave fucose from the non-reducing end of a glycan, represent promising medicinal targets reflecting their roles in cancer metastasis, inflammation, host-parasite interactions and the lysosomal storage disorder fucosidosis. The X-ray crystal structures of Bacteroides theta
  • PMID 23830696
  • Plasmin promotes foam cell formation by increasing macrophage catabolism of aggregated low-density lipoprotein.
  • Haka AS, Grosheva I, Singh RK, Maxfield FR.SourceFrom the Department of Biochemistry, Weill Cornell Medical College, New York, NY.
  • Arteriosclerosis, thrombosis, and vascular biology.Arterioscler Thromb Vasc Biol.2013 Aug;33(8):1768-78. doi: 10.1161/ATVBAHA.112.301109. Epub 2013 May 23.
  • OBJECTIVE: The plasmin/plasminogen system is involved in atherosclerosis. However, the mechanisms by which it stimulates disease are not fully defined. A key event in atherogenesis is the deposition of low-density lipoprotein (LDL) on arterial walls where it is modified, aggregated, and retained. Ma
  • PMID 23702659


  • 糖尿病性腎症の発症にコレステロールを含む凝集タンパク質は関係しているか? : AGE-コレステロール凝集タンパク質は腎メサンギウム細胞においてlysosomal enzymeによって分解される
  • Status of autophagy, lysosome activity and apoptosis during corpus luteum regression in cattle
  • Status of autophagy, lysosome activity and apoptosis during corpus luteum regression in cattle


Malfunction of lysosomal enzymes can result in lysosomal storage diseases such as Tay-Sachs disease and Pompe's disease. Glycosidases alpha-Galactosidase A/GLA alpha-N-acetylgalactosaminidase/NAGA alpha-N alpha-L ...
Lysosomal Acid Hydrolases Lysosomes contain about 50 different degradative enzymes that can hydrolyze proteins, DNA, RNA, polysaccharides, and lipids. Mutations in the genes that encode these enzymes are responsible for ...





  [★] 酵素

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「any of several complex proteins that are produced by cells and act as catalysts in specific biochemical reactions」

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  • adj.
  • リソソームの、ライソソームの