lysine hydroxylase

出典: meddic


procollagen-lysine 2-oxoglutarate 5-dioxygenase

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  • Lysyl hydroxylase 2 induces a collagen cross-link switch in tumor stroma.
  • Chen Y, Terajima M, Yang Y, Sun L, Ahn YH, Pankova D, Puperi DS, Watanabe T, Kim MP, Blackmon SH, Rodriguez J, Liu H, Behrens C, Wistuba II, Minelli R, Scott KL, Sanchez-Adams J, Guilak F, Pati D, Thilaganathan N, Burns AR, Creighton CJ, Martinez ED, Zal T, Grande-Allen KJ, Yamauchi M, Kurie JM.
  • The Journal of clinical investigation.J Clin Invest.2015 Feb 9. pii: 74725. doi: 10.1172/JCI74725. [Epub ahead of print]
  • Epithelial tumor metastasis is preceded by an accumulation of collagen cross-links that heighten stromal stiffness and stimulate the invasive properties of tumor cells. However, the biochemical nature of collagen cross-links in cancer is still unclear. Here, we postulated that epithelial tumorigenes
  • PMID 25664850
  • The in Vivo Effect of Prophylactic Subchondral Bone Protection of Osteoarthritic Synovial Membrane in Bone-Specific Ephb4-Overexpressing Mice.
  • Valverde-Franco G1, Hum D1, Matsuo K2, Lussier B3, Pelletier JP1, Fahmi H1, Kapoor M1, Martel-Pelletier J4.
  • The American journal of pathology.Am J Pathol.2015 Feb;185(2):335-46. doi: 10.1016/j.ajpath.2014.10.004. Epub 2014 Nov 29.
  • Osteoarthritis (OA) is characterized by progressive joint destruction, including synovial membrane alteration. EphB4 and its ligand ephrin-B2 were found in vitro to positively affect OA subchondral bone and cartilage. In vivo in an experimental mouse model overexpressing bone-specific Ephb4 (TgEph
  • PMID 25453723
  • Skin malformations in a neonatal foal tested homozygous positive for Warmblood Fragile Foal Syndrome.
  • Monthoux C, de Brot S, Jackson M, Bleul U, Walter J.
  • BMC veterinary research.BMC Vet Res.2015 Jan 31;11(1):12. [Epub ahead of print]
  • BackgroundSkin malformations that resembled manifestations of Ehlers-Danlos-Syndrome were described in a variety of domestic animals during the last century as cutis hyperelastica, hyperelastosis cutis, dermatosparaxis, dermal/collagen dysplasia, dermal/cutaneous asthenia or Ehlers-Danlos-like syndr
  • PMID 25637337


  • コラーゲンのリシン残基水酸化 : 全身および口腔領域の結合組織の生理・病理学的性状決定に重要な翻訳後修飾
  • 松浦 尚志,片渕 三千綱,徳富 健太郎,佐藤 博信
  • 福岡歯科大学学会雑誌 33(3), 133-145, 2007-09-30
  • … Among extensive posttranslational modifications of collagen, lysine (Lys) hydroxylation is important for physiological and pathophysiological conditions of connective tissues. … The specific Lys residues are catalyzed by three isoforms of lysyl hydroxylase (LH, known as PLOD : procollagen-lysine, 2-oxoglutarate 5-dioxygenase). …
  • NAID 110006436919
  • Effects of Dipeptides Having a C-Terminal Lysine on the Cholesterol 7α-Hydroxylase mRNA Level in HepG2 Cells
  • Morikawa Kensei,Ishikawa Kumiko,Kanamaru Yoshihiro [他],HORI Goro,NAGAOKA Satoshi
  • Bioscience, biotechnology, and biochemistry 71(3), 821-825, 2007-03-23
  • … Inducing expression of the cholesterol-catabolizing enzyme cholesterol 7α-hydroxylase (CYP7A1) in the liver can be an effective strategy in preventing hypercholesterolemia and atherosclerosis. … We used HepG2 cells to investigate the effects of 1 mM dipeptides having a C-terminal lysine group on the CYP7A1 mRNA level. …
  • NAID 10027513099
  • Pharmacological Characteristics of Rotational Behavior in Hemiparkinsonian Rats Transplanted With Mouse Embryonic Stem Cell-Derived Neurons
  • Inden Masatoshi,Kim Dohoon,Gu Yuanjin,Kitamura Yoshihisa,Kondo Jun-ichi,Tsuchiya Daiju,Taniguchi Takashi,Shimohama Shun,Akaike Akinori,Sumi Shoichiro,Inoue Kazutomo
  • Journal of Pharmacological Sciences 96(1), 53-64, 2004
  • … Apomorphine-induced rotation was significantly reduced by transplantation of neuron-like cells that had differentiated from mouse ES cells using nicotinamide, but not <sc><font size = "-2">L</font></sc>-lysine. … Although immunoreactivity for tyrosine hydroxylase (TH) was almost completely lost in the ipsilateral striatum in hemiparkinsonian rats, TH immunoreactivity was detected in transplanted cells and sprouting fibers. …
  • NAID 130000074349


Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase; Lysine hydroxylase; Lysine, 2-oxoglutarate 5-dioxygénase; Procollagène-lysine, 2-oxoglutarate 5-dioxygénase. Aide pour diagnostic médical. Méthode automatique d'associations ...
procollagen-lysine 5-dioxygenase; lysine hydroxylase; lysine,2-oxoglutarate 5-dioxygenase; protocollagen lysine dioxygenase; collagen lysine hydroxylase; lysine-2-oxoglutarate dioxygenase; lysyl hydroxylase; lysylprotocollagen ...



リンク元リジン水酸化酵素」「procollagen-lysine 2-oxoglutarate 5-dioxygenase」「リジンヒドロキシラーゼ



lysine hydroxylase

procollagen-lysine 2-oxoglutarate 5-dioxygenase」



lysine hydroxylase



lysine hydroxylase



WordNet   license wordnet

「any substance (such as an antibody) or agent that can cause lysis」

PrepTutorEJDIC   license prepejdic

「リジン(細胞溶解素), = lysine」


  [★] リジン

WordNet   license wordnet

「an essential amino acid found in proteins; occurs especially in gelatin and casein」


  [★] ヒドロキシラーゼ


  [★] ヒドロキシラーゼ