lymphoid enhancer-binding factor 1

リンパ系エンハンサー結合因子1

関

LEF1

WordNet

1. be a contributing factor; "make things factor into a companys profitability"
2. any of the numbers (or symbols) that form a product when multiplied together
3. an independent variable in statistics
4. anything that contributes causally to a result; "a number of factors determined the outcome"
5. consider as relevant when making a decision; "You must factor in the recent developments" (同)factor in, factor out
6. resolve into factors; "a quantum computer can factor the number 15" (同)factor in, factor out
7. executed with proper legal authority; "a binding contract"
8. the protective covering on the front, back, and spine of a book; "the book had a leather binding" (同)book binding, cover, back
9. strip sewn over or along an edge for reinforcement or decoration
10. the capacity to attract and hold something
11. an event known to have happened or something known to have existed; "your fears have no basis in fact"; "how much of the story is fact and how much fiction is hard to tell"
12. a concept whose truth can be proved; "scientific hypotheses are not facts"
13. a piece of information about circumstances that exist or events that have occurred; "first you must collect all the facts of the case"
14. a statement or assertion of verified information about something that is the case or has happened; "he supported his argument with an impressive array of facts"
15. increase; "This will enhance your enjoyment"; "heighten the tension" (同)heighten, raise
16. make better or more attractive; "This sauce will enhance the flavor of the meat"
17. resembling lymph or lymphatic tissues

PrepTutorEJDIC

1. (…の)『要因』,(…を生み出す)要素《+『in』+『名』(do『ing』)》 / 囲数,約数 / 代理人,《おもに英》仲買人 / =factorize
2. 義務的な,拘束力ある / 〈U〉しばること;〈C〉しばる物 / 〈C〉製本,装丁 / 〈U〉縁(‘ふち')取り材料
3. 〈C〉『事実』,実際にある(あった)事 / 〈U〉真相,真実(truth) / 《the~》(法律用語で)犯行
4. …‘の'程度(仮値など)を高める
5. リンパ状(液)の

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/06/24 04:00:02」(JST)

wiki en

[Wiki en表示]

Lymphoid enhancer-binding factor 1
PDB rendering based on 2lef.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2lef
Identifiers
Symbols	LEF1 ; LEF-1; TCF10; TCF1ALPHA; TCF7L3
External IDs	OMIM: 153245 MGI: 96770 HomoloGene: 7813 GeneCards: LEF1 Gene
Gene ontology Molecular function • RNA polymerase II regulatory region sequence-specific DNA binding • RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription • DNA binding • chromatin binding • sequence-specific DNA binding transcription factor activity • RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity • protein binding • beta-catenin binding • transcription factor binding • DNA binding, bending • estrogen receptor activity • estrogen receptor binding • enhancer binding • histone binding • cysteine-type endopeptidase inhibitor activity involved in apoptotic process • sequence-specific DNA binding • transcription regulatory region DNA binding • gamma-catenin binding • armadillo repeat domain binding • C2H2 zinc finger domain binding Cellular component • nucleus • nucleoplasm • transcription factor complex • cytoplasm • protein-DNA complex Biological process • negative regulation of transcription from RNA polymerase II promoter • patterning of blood vessels • osteoblast differentiation • neural crest cell migration • somitogenesis • epithelial to mesenchymal transition • sprouting angiogenesis • transcription from RNA polymerase II promoter • positive regulation of cell proliferation • positive regulation of gene expression • positive regulation of epithelial to mesenchymal transition • Wnt signaling pathway • regulation of striated muscle tissue development • dentate gyrus development • hypothalamus development • forebrain radial glial cell differentiation • forebrain neuroblast division • forebrain neuron differentiation • formation of radial glial scaffolds • regulation of cell-cell adhesion • negative regulation of cell-cell adhesion • positive regulation of cell-cell adhesion • neutrophil differentiation • positive regulation of cell growth • embryonic limb morphogenesis • positive regulation of cell migration • BMP signaling pathway • positive regulation of granulocyte differentiation • mammary gland development • negative regulation of interleukin-13 production • negative regulation of interleukin-4 production • negative regulation of interleukin-5 production • T cell receptor V(D)J recombination • B cell proliferation • odontogenesis of dentin-containing tooth • negative regulation of apoptotic process • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • negative regulation of DNA binding • steroid hormone mediated signaling pathway • tongue development • positive regulation by host of viral transcription • histone H3 acetylation • histone H4 acetylation • T-helper 1 cell differentiation • negative regulation of striated muscle tissue development • negative regulation of transcription, DNA-templated • positive regulation of transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter • alpha-beta T cell differentiation • eye pigmentation • paraxial mesoderm formation • muscle fiber development • sensory perception of taste • palate development • anatomical structure regression • canonical Wnt signaling pathway • face morphogenesis • cell chemotaxis • apoptotic process involved in morphogenesis • chorio-allantoic fusion • trachea gland development • cellular response to cytokine stimulus • cellular response to interleukin-4 • positive regulation of cell proliferation in bone marrow • negative regulation of apoptotic process in bone marrow • odontoblast differentiation • negative regulation of estrogen receptor binding • positive regulation of cell cycle process • negative regulation of canonical Wnt signaling pathway • apoptotic process involved in patterning of blood vessels Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	51176	16842
Ensembl	ENSG00000138795	ENSMUSG00000027985
UniProt	Q9UJU2	P27782
RefSeq (mRNA)	NM_001130713	NM_001276402
RefSeq (protein)	NP_001124185	NP_001263331
Location (UCSC)	Chr 4: 108.97 – 109.09 Mb	Chr 3: 131.11 – 131.22 Mb
PubMed search	[1]	[2]

Lymphoid enhancer-binding factor 1 (LEF1) is a protein that in humans is encoded by the LEF1 gene.

Function

Lymphoid enhancer-binding factor-1 (LEF1) is a 48-kD nuclear protein that is expressed in pre-B and T cells. It binds to a functionally important site in the T-cell receptor-alpha (TCRA) enhancer and confers maximal enhancer activity. LEF1 belongs to a family of regulatory proteins that share homology with high mobility group protein-1 (HMG1).

Clinical significance

LEF1 is highly overexpressed and associated with disease progression and poor prognosis in B-cell chronic lymphocytic leukemia. It is also a promising potential drug target.

Interactions

Lymphoid enhancer-binding factor 1 has been shown to interact with:

• ALX4,
• AML-1,
• CTNNB1,
• EP300,
• MITF
• PIAS4,
• SMAD2, and
• SMAD3.

References

Further reading

• Waterman ML (2004). "Lymphoid enhancer factor/T cell factor expression in colorectal cancer.". Cancer Metastasis Rev. 23 (1–2): 41–52. doi:10.1023/A:1025858928620. PMID 15000148. 
• Skokowa J, Welte K (2007). "LEF-1 is a decisive transcription factor in neutrophil granulopoiesis". Ann. N. Y. Acad. Sci. 1106: 143–51. doi:10.1196/annals.1392.012. PMID 17360796. 
• Travis A, Amsterdam A, Belanger C, Grosschedl R (1991). "LEF-1, a gene encoding a lymphoid-specific protein with an HMG domain, regulates T-cell receptor alpha enhancer function [corrected]". Genes Dev. 5 (5): 880–94. doi:10.1101/gad.5.5.880. PMID 1827423. 
• van de Wetering M, Oosterwegel M, Dooijes D, Clevers H (1991). "Identification and cloning of TCF-1, a T lymphocyte-specific transcription factor containing a sequence-specific HMG box". EMBO J. 10 (1): 123–32. PMC 452620. PMID 1989880. 
• Waterman ML, Fischer WH, Jones KA (1991). "A thymus-specific member of the HMG protein family regulates the human T cell receptor C alpha enhancer". Genes Dev. 5 (4): 656–69. doi:10.1101/gad.5.4.656. PMID 2010090. 
• Zhou P, Byrne C, Jacobs J, Fuchs E (1995). "Lymphoid enhancer factor 1 directs hair follicle patterning and epithelial cell fate". Genes Dev. 9 (6): 700–13. doi:10.1101/gad.9.6.700. PMID 7537238. 
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• Prieve MG, Guttridge KL, Munguia JE, Waterman ML (1996). "The nuclear localization signal of lymphoid enhancer factor-1 is recognized by two differentially expressed Srp1-nuclear localization sequence receptor proteins". J. Biol. Chem. 271 (13): 7654–8. doi:10.1074/jbc.271.13.7654. PMID 8631802. 
• Behrens J, von Kries JP, Kühl M et al. (1996). "Functional interaction of beta-catenin with the transcription factor LEF-1". Nature 382 (6592): 638–42. doi:10.1038/382638a0. PMID 8757136.  CS1 maint: Explicit use of et al. (link)
• Bagga R, Emerson BM (1997). "An HMG I/Y-containing repressor complex and supercoiled DNA topology are critical for long-range enhancer-dependent transcription in vitro". Genes Dev. 11 (5): 629–39. doi:10.1101/gad.11.5.629. PMID 9119227. 
• Bruhn L, Munnerlyn A, Grosschedl R (1997). "ALY, a context-dependent coactivator of LEF-1 and AML-1, is required for TCRalpha enhancer function". Genes Dev. 11 (5): 640–53. doi:10.1101/gad.11.5.640. PMID 9119228. 
• Brannon M, Gomperts M, Sumoy L et al. (1997). "A beta-catenin/XTcf-3 complex binds to the siamois promoter to regulate dorsal axis specification in Xenopus". Genes Dev. 11 (18): 2359–70. doi:10.1101/gad.11.18.2359. PMC 316518. PMID 9308964.  CS1 maint: Explicit use of et al. (link)
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.  CS1 maint: Explicit use of et al. (link)
• Korinek V, Barker N, Willert K et al. (1998). "Two members of the Tcf family implicated in Wnt/beta-catenin signaling during embryogenesis in the mouse". Mol. Cell. Biol. 18 (3): 1248–56. PMC 108837. PMID 9488439.  CS1 maint: Explicit use of et al. (link)
• Prieve MG, Guttridge KL, Munguia J, Waterman ML (1998). "Differential importin-alpha recognition and nuclear transport by nuclear localization signals within the high-mobility-group DNA binding domains of lymphoid enhancer factor 1 and T-cell factor 1". Mol. Cell. Biol. 18 (8): 4819–32. PMC 109067. PMID 9671491. 
• Levanon D, Goldstein RE, Bernstein Y et al. (1998). "Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors". Proc. Natl. Acad. Sci. U.S.A. 95 (20): 11590–5. doi:10.1073/pnas.95.20.11590. PMC 21685. PMID 9751710.  CS1 maint: Explicit use of et al. (link)
• Hovanes K, Li TW, Waterman ML (2000). "The human LEF-1 gene contains a promoter preferentially active in lymphocytes and encodes multiple isoforms derived from alternative splicing". Nucleic Acids Res. 28 (9): 1994–2003. doi:10.1093/nar/28.9.1994. PMC 103301. PMID 10756202. 
• Labbé E, Letamendia A, Attisano L (2000). "Association of Smads with lymphoid enhancer binding factor 1/T cell-specific factor mediates cooperative signaling by the transforming growth factor-beta and wnt pathways". Proc. Natl. Acad. Sci. U.S.A. 97 (15): 8358–63. doi:10.1073/pnas.150152697. PMC 26952. PMID 10890911. 
• Brantjes H, Roose J, van De Wetering M, Clevers H (2001). "All Tcf HMG box transcription factors interact with Groucho-related co-repressors". Nucleic Acids Res. 29 (7): 1410–9. doi:10.1093/nar/29.7.1410. PMC 31284. PMID 11266540. 

External links

• LEF1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

• 1. 成人における骨髄異形成症候群の予後 prognosis of the myelodysplastic syndromes in adults
• 2. 先天性好中球減少症 congenital neutropenia

English Journal

• Bmp7 and lef1 are the downstream effectors of androgen signaling in androgen-induced sex characteristics development in medaka.

• Ogino Y, Hirakawa I, Inohaya K, Sumiya E, Miyagawa S, Denslow N, Yamada G, Tatarazako N, Iguchi T.Author information Okazaki Institute for Integrative Bioscience (Y.O., I.H., E.S., S.M., T.I.), National Institute for Basic Biology, National Institutes of Natural Sciences, and Department of Basic Biology (Y.O., I.H., E.S., S.M., T.I.), Faculty of Life Science, The Graduate University for Advanced Studies, Aichi 444-8787, Japan; Department of Biological Information (K.I.), Tokyo Institute of Technology, Yokohama 226-8501, Japan; Department of Physiological Sciences (N.D.), Center for Environmental and Human Toxicology, University of Florida, Gainesville, Florida 32611; Department of Developmental Genetics (G.Y.), Institute of Advanced Medicine, Wakayama Medical University, Wakayama 641-8509, Japan; and National Institute for Environmental Studies (N.T.), Ibaraki, 305-8506, Japan.AbstractAndrogens play key roles in the morphological specification of male type sex attractive and reproductive organs, whereas little is known about the developmental mechanisms of such secondary sex characters. Medaka offers a clue about sexual differentiation. They show a prominent masculine sexual character for appendage development, the formation of papillary processes in the anal fin, which has been induced in females by exogenous androgen exposure. This current study shows that the development of papillary processes is promoted by androgen-dependent augmentation of bone morphogenic protein 7 (Bmp7) and lymphoid enhancer-binding factor-1 (Lef1). Androgen receptor (AR) subtypes, ARα and ARβ, are expressed in the distal region of outgrowing bone nodules of developing papillary processes. Development of papillary processes concomitant with the induction of Bmp7 and Lef1 in the distal bone nodules by exposure to methyltestosterone was significantly suppressed by an antiandrogen, flutamide, in female medaka. When Bmp signaling was inhibited in methyltestosterone-exposed females by its inhibitor, dorsomorphin, Lef1 expression was suppressed accompanied by reduced proliferation in the distal bone nodules and retarded bone deposition. These observations indicate that androgen-dependent expressions of Bmp7 and Lef1 are required for the bone nodule outgrowth leading to the formation of these secondary sex characteristics in medaka. The formation of androgen-induced papillary processes may provide insights into the mechanisms regulating the specification of sexual features in vertebrates.
• Endocrinology.Endocrinology.2014 Feb;155(2):449-62. doi: 10.1210/en.2013-1507. Epub 2013 Nov 18.
• Androgens play key roles in the morphological specification of male type sex attractive and reproductive organs, whereas little is known about the developmental mechanisms of such secondary sex characters. Medaka offers a clue about sexual differentiation. They show a prominent masculine sexual char
• PMID 24248458

• Buffalo alpha S1-casein gene 5'-flanking region and its interspecies comparison.

• Patel AK, Singh M, Suryanarayana VV.Author information Department of Animal Biotechnology, College of Veterinary Science and Animal Husbandry, Anand Agricultural University, Anand, India.AbstractThe expression of milk protein genes is tightly regulated in a spatio-temporal manner through the combinatorial interaction of lactogenic hormones and a set of transcription factors mediating developmental and tissue-specific gene expression. The recruitment of a unique set of transcription factors is determined by the cis-regulatory motifs present in the gene promoter region. Here, we report the isolation, sequencing, structural analysis and interspecies comparison of the 5'cis-regulatory region of the buffalo alpha S1 (αS1)-casein gene. The proximal promoter region of the buffalo αS1-casein gene harbored the insertion of a 72-bp fragment of long interspersed nuclear element of the L1_BT retrotransposon family. Among the core and vertebrate-specific promoter elements, the motifs for the binding of Brn POU domain factors (BRNF), Lim homeodomain factors (LHXF), NK6 homeobox transcription factors (NKX6), nuclear factor kappa B/c-rel (NFKB), AT-rich interactive domain factor (ARID), Brn POU domain factor 5 (BRN5), pancreatic and intestinal homeodomain transcription factor (PDX1), Distal-less homeodomain transcription factors (DLXF), T-cell factor/lymphoid enhancer-binding factor-1 (LEFF) and GHF-1 pituitary-specific POU domain transcription factor (PIT1) were over-represented in the αS1-casein gene regulatory region (Z score >4.0). The Multiple EM for Motif elicitation predicted three motifs which consisted of the sequences known to bind mammary gland factor/signal transducer and activator of transcription 5 (MGF/STAT5), estrogen receptor-related alpha (ERα), steroidogenic factor 1 (SF1) and glucocorticoid receptor (GR), indicating their potential role in the mammary gland-specific gene expression. The interspecies comparison of the proximal promoter region revealed conserved sequences for TATA boxes and MGF/STAT5 in all species, whereas activator protein 1 (AP1), pregnancy-specific mammary nuclear factor (PMF), CCAAT/enhancer binding protein (C/EBP), double-stranded and single-stranded DNA-binding protein 1 (DS1 and SS), ying and yang factor 1 (YY1), and GR half-sites were among ruminants. The functional significance of the L1_BT retrotransposon insertion on the buffalo αS1-casein gene expression needs to be experimentally validated.
• Journal of applied genetics.J Appl Genet.2014 Feb;55(1):75-87. doi: 10.1007/s13353-013-0176-7. Epub 2013 Oct 19.
• The expression of milk protein genes is tightly regulated in a spatio-temporal manner through the combinatorial interaction of lactogenic hormones and a set of transcription factors mediating developmental and tissue-specific gene expression. The recruitment of a unique set of transcription factors
• PMID 24142689

• Clinical significance of lymphoid enhancer-binding factor 1 expression in acute myeloid leukemia.

• Fu Y, Zhu H, Wu W, Xu J, Chen T, Xu B, Qian S, Li J, Liu P.Author information Department of Hematology.AbstractAbstract Lymphoid enhancer-binding factor 1 (LEF1) is a downstream effector of the Wnt/β-catenin signaling pathway and its dysregulation is associated with a number of malignant diseases such as leukemia. We explored the expression profile of LEF1 in acute myeloid leukemia (AML) and determined its specific prognostic significance in this disease. The LEF1 mRNA level in patients with previously untreated AML was significantly higher than in normal controls. Patients with AML with relatively higher LEF1 expression were more likely to achieve a complete remission (CR) following induction therapy in comparison to those with a lower LEF1 level. Moreover, we provide the first evidence that primary AML samples with AML1-ETO or PML-RARα have a higher LEF1 level compared with those without each fusion gene. High LEF1 expression predicts a significantly better overall survival for patients with intermediate-risk cytogenetics. High LEF1 level was associated with a favorable relapse-free survival in patients with FLT3-ITD wild-type. Finally, a scoring system based on LEF1 level and mutation status of FLT3-ITD or NPM1 is reliable to predict the outcome for AML with intermediate-risk cytogenetics. Our results indicate that LEF1 contributes to the pathophysiology of AML and could serve as a novel predictor of better treatment response. LEF1 level may be incorporated into an improved risk classification system for certain specific subtypes of AML.
• Leukemia & lymphoma.Leuk Lymphoma.2014 Feb;55(2):371-7. doi: 10.3109/10428194.2013.805759. Epub 2013 Jul 8.
• Abstract Lymphoid enhancer-binding factor 1 (LEF1) is a downstream effector of the Wnt/β-catenin signaling pathway and its dysregulation is associated with a number of malignant diseases such as leukemia. We explored the expression profile of LEF1 in acute myeloid leukemia (AML) and determined its
• PMID 23713453

Japanese Journal

• Intestinal Peyer's patches prevent tumorigenesis in ApcMin/+ mice

• Fujimoto Kyoko,Fujii Gen,Sakurai Hitomi,Yoshitome Hiroko,Mutoh Michihiro,Wada Morimasa
• Journal of Clinical Biochemistry and Nutrition, 2015
• … Increasing the number of Peyer's patches decreased interleukin-17 production, which showed a dose dependent correlation with transcription factor/lymphoid enhancer-binding factor. …
• NAID 130004704978

• Immunolocalization of SP6, LEF1 and Associated Factors in the Tooth Germ of Rat Molars

• Moriguchi Mitsuko,Kosika Mayu,Miake Yasuo,Yamaguchi Yasuaki,Yamazaki Takaki,Yamamoto Hitoshi
• Journal of Hard Tissue Biology 22(4), 481-488, 2013
• … Lymphoid enhancer-binding factor 1 (LEF1) is a transcription factor in the Wnt/β-catenin signaling pathway. … Specificity Protein 6/Epiprofin (SP6) is a transcription factor that mediates the signaling pathway between bone morphogenetic protein (BMP) and the Wnt/β-catenin. …
• NAID 130004480620

• Association of smads with lymphoid enhancer binding factor 1/T cell-specific factor mediates cooperative signaling by the transforming growth factor-beta and wnt pathways

• LABBE E
• Proc Natl Acad Sci USA 97(15), 8358-8363, 2000
• NAID 80011893073

Related Links

• Lymphoid enhancer-binding factor 1 - Wikipedia, the free ...

Lymphoid enhancer-binding factor-1 (LEF1) is a 48-kD nuclear protein that is expressed in pre-B and T cells. It binds to a functionally important site in the T-cell receptor-alpha (TCRA) enhancer and confers maximal enhancer activity.

• High expression of lymphoid enhancer-binding factor-1 (LEF1) is a ...

Blood. 2012 Sep 6;120(10):2118-26. doi: 10.1182/blood-2012-02-411827. Epub 2012 Jul 18. High expression of lymphoid enhancer-binding factor-1 (LEF1) is a novel favorable prognostic factor in cytogenetically normal acute myeloid ...

Related Pictures

---

★リンクテーブル★

リンク元	「LEF1」「リンパ系エンハンサー結合因子1」
関連記事	「binding」「enhance」「fact」「factor」「lymphoid」

「LEF1」

　　[★]

• リンパ系エンハンサー結合因子1

関

lymphoid enhancer-binding factor 1

「リンパ系エンハンサー結合因子1」

　　[★]

英

lymphoid enhancer-binding factor 1、LEF1

「binding」

　　[★]

• n.

• 結合、バインディング

• adj.

• 結合性の

関

affinity、associate、bind、bond、bonding、combine、conjoin、conjugate、conjugation、conjunction、connect、connection、connective、connectivity、couple、dock、engage、engagement、join、ligate、linkage、symphysial、symphysic、union

　 　 　 　 　

「enhance」

　　[★]

• v.

• 増強する、亢進する、強化する、強める

関

augment、augmentation、consolidate、consolidation、enhancement、facilitate、facilitation、fortification、fortify、intensification、intensify、potentiate、potentiation、reinforce、reinforcement、sharpen、strengthen

　 　 　

「fact」

　　[★]

• n.

• 事実、現状、実際、実態

関

actual、actually、in fact、in practice、indeed、practically

　 　 　 　 　

「factor」

　　[★]

• n.

• 因子、要因、要素、ファクター

関

element、elementary、factorial、parameter

　 　 　 　 　 　 　

「lymphoid」

　　[★]

• adj.

• リンパ様、リンパ系の

関

lymphatic system