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inflammation of the colon (同)inflammatory_bowel_disease
of or relating to lymphocytes; "lymphocytic leukemia"

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結腸炎

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/05/24 15:49:44」(JST)

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Lymphocytic colitis is a subtype of microscopic colitis, a condition characterized by chronic non-bloody watery diarrhea.^[1]^[2] The colonoscopy is normal but histology of the mucosal biopsy reveals an accumulation of lymphocytes in the colonic epithelium and connective tissue (lamina propria). Collagenous colitis shares this feature but additionally shows a distinctive thickening of the subepithelial collagen table. The peak incidence of lymphocytic colitis is in persons over age 50; the disease affects women and men equally. Lymphocytic colitis was first described in 1989.^[3]

Causes

No definite etiology has been determined. Some reports have implicated long-term usage of NSAIDs, antidepressants specifically Sertraline (Zoloft), and other drugs; and overactive immune responses are also suspected.

Treatment

Budesonide, in colonic release preparations, has been shown in randomized controlled trials to be effective in treating this disorder.^[4]^[5] It helps control the diarrheal symptoms and treatment is usually given for several weeks. Sometimes it is used to prevent frequent relapses.

Over-the-counter antidiarrheal drugs may be effective for some people with lymphocytic colitis. Anti-inflammatory drugs, such as salicylates, Mesalazine, and systemic corticosteroids may be prescribed for people who do not respond to other drug treatment. The long-term prognosis for this disease is good with a proportion of people suffering relapses which respond to treatment.^[1]

References

^ ^a ^b Münch A, Aust D, Bohr J, Bonderup O, Fernández Bañares F, Hjortswang H, et al. (2012). "Microscopic colitis: Current status, present and future challenges: statements of the European Microscopic Colitis Group.". J Crohns Colitis 6 (9): 932–45. doi:10.1016/j.crohns.2012.05.014. PMID 22704658.
^ Rasmussen MA, Munck LK (2012). "Systematic review: are lymphocytic colitis and collagenous colitis two subtypes of the same disease - microscopic colitis?". Aliment Pharmacol Ther 36 (2): 79–90. doi:10.1111/j.1365-2036.2012.05166.x. PMID 22670660.
^ Lazenby AJ, Yardley JH, Giardiello FM, Jessurun J, Bayless TM (1989). "Lymphocytic ("microscopic") colitis: a comparative histopathologic study with particular reference to collagenous colitis". Hum. Pathol. 20 (1): 18–28. PMID 2912870.
^ Chande N, MacDonald JK, McDonald JW (2009). "Interventions for treating microscopic colitis: a Cochrane Inflammatory Bowel Disease and Functional Bowel Disorders Review Group systematic review of randomized trials.". Am J Gastroenterol 104 (1): 235–41; quiz 234, 242. doi:10.1038/ajg.2008.16. PMID 19098875.
^ Fernández-Bañares F, Salas A, Esteve M, Espinós J, Forné M, Viver J (2003). "Collagenous and lymphocytic colitis. evaluation of clinical and histological features, response to treatment, and long-term follow-up.". Am J Gastroenterol 98 (2): 340–7. doi:10.1111/j.1572-0241.2003.07225.x. PMID 12591052.

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1. リンパ球性大腸炎および膠原線維性大腸炎（顕微鏡的大腸炎） lymphocytic and collagenous colitis microscopic colitis
2. 先進国の成人における慢性下痢に対するアプローチ approach to the adult with chronic diarrhea in developed countries
3. 小児における慢性下痢の原因の概要 overview of the causes of chronic diarrhea in children
4. 成人における大腸内視鏡検査の概要 overview of colonoscopy in adults
5. 消化器疾患に対するプロバイオティクス probiotics for gastrointestinal diseases

English Journal

Differential Expression of miR-31 between Inflammatory Bowel Disease and Microscopic Colitis.

Zhang C, Zhao Z, Osman H, Watson R, Nalbantoglu I, Lin J1.
MicroRNA (Shariqah, United Arab Emirates).Microrna.2015 Feb 8. [Epub ahead of print]
Background: Idiopathic inflammatory bowel disease (IBD) and microscopic colitis (MC) are distinct entities. However, patients with intermittent episodes of IBD and MC that are encountered in a clinical setting puzzle clinicians and pathologists. This study examined whether microRNA assisted in the c
PMID 25665881

The epidemiology of microscopic colitis: a 10-year pathology-based nationwide Danish cohort study.

Bonderup OK1, Wigh T, Nielsen GL, Pedersen L, Fenger-Grøn M.
Scandinavian journal of gastroenterology.Scand J Gastroenterol.2015 Feb 3:1-6. [Epub ahead of print]
Abstract Objective. Microscopic colitis (MC) includes two main types: collagenous colitis (CC) and lymphocytic colitis (LC). Previous studies have indicated an increasing incidence, but these have mainly been based on regional databases. We found it important to study the epidemiology based on a com
PMID 25645623

Incidence, Prevalence, and Temporal Trends of Microscopic Colitis: A Systematic Review and Meta-Analysis.

Tong J1, Zheng Q1, Zhang C2, Lo R3, Shen J4, Ran Z4.
The American journal of gastroenterology.Am J Gastroenterol.2015 Feb;110(2):265-276. doi: 10.1038/ajg.2014.431. Epub 2015 Jan 27.
Objectives:A systematic review and meta-analysis was conducted to provide an accurate estimate of the incidence rate of microscopic colitis (MC) and to assess the association between medication use and the risk of MC.Methods:We searched Medline, Embase, and Institute for Scientific Information (ISI)
PMID 25623658

Japanese Journal

顕微鏡的大腸炎に対するプレドニゾロンおよびブデソニド短期・長期投与の効果 : システマティックレビューとメタアナリシス

小坂俊仁,芳野純治,STEWART MICHAEL J. [他]
Review of gastroenterology & clinical gastroenterology and hepatology 7(1), 37-42, 2012-05
NAID 40019321718

Role of Sulfated O-Glycans Expressed by High Endothelial Venule-Like Vessels in Pathogenesis of Chronic Inflammatory Gastrointestinal Diseases

Kobayashi Motohiro,Fukuda Minoru,Nakayama Jun
Biological and Pharmaceutical Bulletin 32(5), 774-779, 2009
… Such HEV-like vessels have been observed in various chronic inflammatory diseases including rheumatoid arthritis, lymphocytic thyroiditis, Helicobacter pylori-associated chronic gastritis, and inflammatory bowel disease (IBD), and implicated in lymphocyte recruitment in those diseases. …
NAID 130000117137

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関連記事	「lymphocytic」

「lymphocytic」

Lymphocytic colitis
	Micrograph of lymphocytic colitis. HPS stain.
Classification and external resources
DiseasesDB	30087
eMedicine	med/1351
MeSH	D046730
	[edit on Wikidata]

　　[★]

adj.

リンパ球性の、リンパ性の、リンパ球系の

関: lymphatic

[pmid22704658-1] Münch A, Aust D, Bohr J, Bonderup O, Fernández Bañares F, Hjortswang H, et al. (2012). "Microscopic colitis: Current status, present and future challenges: statements of the European Microscopic Colitis Group.". J Crohns Colitis 6 (9): 932–45. doi:10.1016/j.crohns.2012.05.014. PMID 22704658.

[pmid22670660-2] Rasmussen MA, Munck LK (2012). "Systematic review: are lymphocytic colitis and collagenous colitis two subtypes of the same disease - microscopic colitis?". Aliment Pharmacol Ther 36 (2): 79–90. doi:10.1111/j.1365-2036.2012.05166.x. PMID 22670660.

[pmid2912870-3] Lazenby AJ, Yardley JH, Giardiello FM, Jessurun J, Bayless TM (1989). "Lymphocytic ("microscopic") colitis: a comparative histopathologic study with particular reference to collagenous colitis". Hum. Pathol. 20 (1): 18–28. PMID 2912870.

[pmid19098875-4] Chande N, MacDonald JK, McDonald JW (2009). "Interventions for treating microscopic colitis: a Cochrane Inflammatory Bowel Disease and Functional Bowel Disorders Review Group systematic review of randomized trials.". Am J Gastroenterol 104 (1): 235–41; quiz 234, 242. doi:10.1038/ajg.2008.16. PMID 19098875.

[fernandez-5] Fernández-Bañares F, Salas A, Esteve M, Espinós J, Forné M, Viver J (2003). "Collagenous and lymphocytic colitis. evaluation of clinical and histological features, response to treatment, and long-term follow-up.". Am J Gastroenterol 98 (2): 340–7. doi:10.1111/j.1572-0241.2003.07225.x. PMID 12591052.

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lymphocytic colitis