同: LFA-1

WordNet

having partial rights and privileges or subordinate status; "an associate member"; "an associate professor"
a person who joins with others in some activity or endeavor; "he had to consult his associate before continuing"
a person with subordinate membership in a society, institution, or commercial enterprise; "associates in the law firm bill at a lower rate than do partners"
any event that usually accompanies or is closely connected with another; "first was the lightning and then its thunderous associate"
make a logical or causal connection; "I cannot connect these two pieces of evidence in my mind"; "colligate these facts"; "I cannot relate these events at all" (同)tie_in, relate, link, colligate, link up, connect
perform as expected when applied; "The washing machine wont go unless its plugged in"; "Does this old car still run well?"; "This old radio doesnt work anymore" (同)work, operate, go, run
(mathematics) a mathematical relation such that each element of a given set (the domain of the function) is associated with an element of another set (the range of the function) (同)mathematical function, single-valued function, map, mapping
a relation such that one thing is dependent on another; "height is a function of age"; "price is a function of supply and demand"
the actions and activities assigned to or required or expected of a person or group; "the function of a teacher"; "the government must do its part"; "play its role" (同)office, part, role
what something is used for; "the function of an auger is to bore holes"; "ballet is beautiful but what use is it?" (同)purpose, role, use
a formal or official social gathering or ceremony; "it was a black-tie function"
any substance (as a toxin or enzyme) that stimulates an immune response in the body (especially the production of antibodies)
an agranulocytic leukocyte that normally makes up a quarter of the white blood cell count but increases in the presence of infection (同)lymph cell
performing or able to perform its regular function; "a functioning flashlight"

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〈人〉'を'(…の)『仲間に加える』,(…に)連合させる《+『名』〈人〉+『with』+『名』》 / (…と)…'を'結びつけて考える(起こす)《+『名』+『with』+『名』》 / (…と)『仲間になる』,交際する《+『with』+『名』》 / (…と)合体する,提携する《+『with』+『名』》 / 『仲間』,『同僚』;組合員 / 準会員 / 付属物;連想されるもの / 連合した;仲間の,同僚の / 補助の,準…
(人・物の果たすべき)『働き』,機能,役目;《しばしば複数形で》職務 / (公式の)儀式,《話》大きな催し(集まり),式典 / (数学で)関数 / 〈機械などが〉『機能を果たす』,動く / (…の)役目をする,代用となる《+『as』+『名』》
抗原(生物の体内にはいって免疫体を作る物質)

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2019/04/14 01:40:57」(JST)

wiki en

Lymphocyte function-associated antigen 1 (LFA-1) is an integrin found on lymphocytes and other leukocytes.^[1] LFA-1 plays a key role in emigration, which is the process by which leukocytes leave the bloodstream to enter the tissues. LFA-1 also mediates firm arrest of leukocytes.^[2] Additionally, LFA-1 is involved in the process of cytotoxic T cell mediated killing as well as antibody mediated killing by granulocytes and monocytes.^[3] As of 2007, LFA-1 has 6 known ligands: ICAM-1, ICAM-2, ICAM-3, ICAM-4, ICAM-5, and JAM-A.^[2] LFA-1/ICAM-1 interactions have recently been shown to stimulate signaling pathways that influence T cell differentiation.^[4] LFA-1 belongs to the integrin superfamily of adhesion molecules.^[1]

Structure

LFA-1 is a heterodimeric glycoprotein with non-covalently linked subunits.^[3] LFA-1 has two subunits designated as the alpha subunit and beta subunit.^[2] The alpha subunit was named aL in 1983.^[2] The alpha subunit is designated CD11a; and the beta subunit, unique to leukocytes, is beta-2 or CD18.^[2] The ICAM binding site is on the alpha subunit.^[5] The general binding region of the alpha subunit is the I-domain. Due to the presence of a divalent cation site in the I-domain, the specific binding site is often referred to as the metal-ion dependent adhesion site (MIDAS).^[5]

Activation

In an inactive state, LFA-1 rests in a bent conformation and has a low affinity for ICAM binding.^[5] This bent conformation conceals the MIDAS. Chemokines stimulate the activation process of LFA-1.^[5] The activation process begins with the activation of Rap1, an intracellular g-protein.^[2] Rap1 assists in breaking the constraint between the alpha and beta subunits of LFA-1.^[2] This induces an intermediate extended conformation.^[2] The conformational change stimulates a recruitment of proteins to form an activation complex. The activation complex further destabilizes the alpha and beta subunits.^[2] Chemokines also stimulate an I-like domain on the beta subunit, which causes the MIDAS site on the beta subunit to bind to glutamate on the I domain of the alpha subunit.^[5] This binding process causes the beta subunit to pull down the alpha 7 helix of the I domain, exposing and opening up the MIDAS site on the alpha subunit for binding.^[5] This causes LFA-1 to undergo a conformational change to the fully extended conformation. The process of activating LFA-1 is known as inside out signaling, which causes LFA-1 to shift from low affinity to high affinity by opening the ligand-binding site.^[5]

Discovery

Early discovery of cellular adhesion molecules involved the use of monoclonal antibodies to inhibit cellular adhesion processes.^[2] The antigen that bound to the monoclonal antibodies was identified as an important molecule in cellular recognition processes.^[2] These experiments yielded the protein name “integrin” as a description of the proteins' integral role in cellular adhesion processes and the transmembrane association between the extracellular matrix and the cytoskeleton.^[2] LFA-1, a leukocyte integrin, was first discovered by Timothy Springer in mice in the 1980s.^[2]

Leukocyte Adhesion Deficiency (LAD)

Leukocyte adhesion deficiency is an immunodeficiency caused by the absence of key adhesion surface proteins, including LFA-1.^[6] LAD is a genetic defect caused by autosomal recessive genes.^[6] The deficiency causes ineffective migration and phagocytosis for impacted leukocytes.^[3] Patients with LAD also have poorly functioning neutrophils.^[2] LAD1, a subtype of LAD, is caused by a lack of integrins that contain the beta subunit, including LFA-1.^[3] LAD1 is characterized by recurring bacterial infection, delayed (>30 days) separation of umbilical cord, ineffective wound healing and pus formation, and granulocytosis.^[7] LAD1 is caused by low expression of CD11 and CD18. CD18 is found on chromosome 21 and CD11 is found on chromosome 16.^[6]

References

^ ^a ^b M., Lackie, J. (2010). A dictionary of biomedicine (1st ed.). Oxford: Oxford University Press. ISBN 9780191727948. OCLC 663104793.
^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k ^l ^m ⁿ Adhesion molecules : function and inhibition. Ley, Klaus, 1957-. Basel: Birkhauser. 2007. ISBN 9783764379759. OCLC 261225084.
^ ^a ^b ^c ^d Oxford dictionary of biochemistry and molecular biology. Cammack, Richard, Ph. D. (Rev. ed.). Oxford: Oxford University Press. 2006. ISBN 9780191727641. OCLC 743217704.
^ Verma NK, Kelleher D (August 2017). "Not Just an Adhesion Molecule: LFA-1 Contact Tunes the T Lymphocyte Program". Journal of Immunology. 199 (4): 1213–1221. doi:10.4049/jimmunol.1700495. PMID 28784685.
^ ^a ^b ^c ^d ^e ^f ^g Protein-protein interactions in drug discovery. Dömling, Alexander. Weinheim: Wiley-VCH. 2013. ISBN 9783527648238. OCLC 828743731.
^ ^a ^b ^c Akbari, H.; Zadeh, M. M. (January 2001). "Leukocyte adhesion deficiency". Indian Journal of Pediatrics. 68 (1): 77–79. ISSN 0019-5456. PMID 11237241.
^ Anderson, D. C.; Springer, T. A. (1987). "Leukocyte adhesion deficiency: an inherited defect in the Mac-1, LFA-1, and p150,95 glycoproteins". Annual Review of Medicine. 38: 175–194. doi:10.1146/annurev.me.38.020187.001135. ISSN 0066-4219. PMID 3555290.

External links

LFA-1 at the US National Library of Medicine Medical Subject Headings (MeSH)
ITGAL ITGB2 Info with links in the Cell Migration Gateway

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 炎症の病因における白血球内皮細胞接着 leukocyte endothelial adhesion in the pathogenesis of inflammation
2. 白血球粘着不全症 leukocyte adhesion deficiency
3. 抗原提示細胞 antigen presenting cells
4. 全身性硬化症（強皮症）の病因 pathogenesis of systemic sclerosis scleroderma
5. 薬物誘発性ループス drug induced lupus

English Journal

Regulation of integrin affinity on cell surfaces.

Schurpf T, Springer TA.SourceDepartment of Pathology, Harvard Medical School, Immune Disease Institute and Children's Hospital, Boston, MA, USA.
The EMBO journal.EMBO J.2011 Sep 23. doi: 10.1038/emboj.2011.333. [Epub ahead of print]
Lymphocyte activation triggers adhesiveness of lymphocyte function-associated antigen-1 (LFA-1; integrin α(L)β(2)) for intercellular adhesion molecules (ICAMs) on endothelia or antigen-presenting cells. Whether the activation signal, after transmission through multiple domains to the ligand-bindin
PMID 21946563

Dual-functional capability of CD3+CD56+ CIK cells, a T-cell subset that acquires NK function and retains TCR-mediated specific cytotoxicity.

Pievani A, Borleri G, Pende D, Moretta L, Rambaldi A, Golay J, Introna M.SourceLaboratory of Cellular Therapy "G. Lanzani," USC Hematology, Ospedali Riuniti di Bergamo, Bergamo, Italy;
Blood.Blood.2011 Sep 22;118(12):3301-10. Epub 2011 Aug 5.
CD3(+)CD56(+) cytokine-induced killer (CIK) cells display a potent cytolytic activity. The adhesion molecule lymphocyte function-associated antigen-1 plays a crucial role in binding as well as in cytolytic activity of CIK cells against tumor target cells expressing the corresponding ligands. CIK cel
PMID 21821703

Japanese Journal

OP-046-4 細胞内ポリアミンによるLFA-1(Lymphocyte Function-Associated Antigen-1)発現変化のメカニズムに関する検討(免疫-2,一般口演,第110回日本外科学会定期学術集会)

加納良彦,早田邦康,小西文雄
日本外科学会雑誌 111(臨時増刊号_2), 361, 2010-03-05
NAID 110007716080

DNAM-1とTh細胞の分化

甲斐平康,渋谷和子
臨床免疫・アレルギー科 48(1), 98-104, 2007-07
NAID 40015604927

Related Pictures

★リンクテーブル★

リンク元	「LFA-1」「リンパ球機能関連抗原1」
関連記事	「associate」「function」「associated」「lymphocyte」

「LFA-1」

　　[★]

関: lymphocyte function-associated antigen-1, leukocyte function-associated antigen 1
同: リンパ球機能関連抗原1
関: リンパ球機能関連抗原 LFA、インテグリン

同: CDlla

first aid step1 2006 p.190

臨床関連

白血球粘着不全症 leukocyte adhesion deficiency

「リンパ球機能関連抗原1」

　　[★]

英: lymphocyte function-associated antigen-1、LFA-1

「associate」

　　[★]

vt.

結合する、連合させる。連想によって結びつける。(人を)仲間/友達などとしての関係に置く。(化)会合させる

vi.

仲間/友人などとして交際する(with)。一つにまとめる、連合する

n.

仕事仲間、提携者、同僚。友人、朋友。準会員。従業員、社員
密接な蒸す偽付きのある物、付随する物、つきもの。準国家
連想によって心に浮かぶ言葉/思い、連想物

adj.

仲間の、同僚の。製紙機械員に次ぐ資格の
付随する、連想される

関: accompany、association、associative、attach、bearing、bind、binding、bond、bonding、coassemble、colleague、combine、conjoin、conjugate、conjugation、conjunction、connect、connection、correlate、correlation、couple、dock、engage、engagement、federation、implication、join、joint、ligate、link、linkage、peer、pertinent、reference、relate、relation、relationship、relative、relevance、relevant、symphysial、union

「function」

　　[★]

n.

機能、(数学)関数、(化学)官能基

survival as a function of HbA1c in people with type 2 diabetes HbA1cの機能を考慮（指標に）した2型糖尿病の患者の生存（予後）

Figure 2A shows survival as a function of device removal during index hpspitalization, censored at 1 year or date of last contact. (Figure2Aはは最初の入院中における心臓デバイス除去に関する生存曲線で退院後1年もしくは最後の接触で打ち切っている)

v.

機能する

関: functional、functional group、functionalise、functionalize、operate

「associated」

　　[★]

adj.

随伴の、随伴性の

関: concomitant、erratic、erratically; associate

「lymphocyte」

　　[★] リンパ球

同: lymphocytes＆development

[:0-1] M., Lackie, J. (2010). A dictionary of biomedicine (1st ed.). Oxford: Oxford University Press. ISBN 9780191727948. OCLC 663104793.

[:1-2] ^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k ^l ^m ⁿ Adhesion molecules : function and inhibition. Ley, Klaus, 1957-. Basel: Birkhauser. 2007. ISBN 9783764379759. OCLC 261225084.

[:2-3] Oxford dictionary of biochemistry and molecular biology. Cammack, Richard, Ph. D. (Rev. ed.). Oxford: Oxford University Press. 2006. ISBN 9780191727641. OCLC 743217704.

[4] Verma NK, Kelleher D (August 2017). "Not Just an Adhesion Molecule: LFA-1 Contact Tunes the T Lymphocyte Program". Journal of Immunology. 199 (4): 1213–1221. doi:10.4049/jimmunol.1700495. PMID 28784685.

[:3-5] ^ ^a ^b ^c ^d ^e ^f ^g Protein-protein interactions in drug discovery. Dömling, Alexander. Weinheim: Wiley-VCH. 2013. ISBN 9783527648238. OCLC 828743731.

[:4-6] Akbari, H.; Zadeh, M. M. (January 2001). "Leukocyte adhesion deficiency". Indian Journal of Pediatrics. 68 (1): 77–79. ISSN 0019-5456. PMID 11237241.

[7] Anderson, D. C.; Springer, T. A. (1987). "Leukocyte adhesion deficiency: an inherited defect in the Mac-1, LFA-1, and p150,95 glycoproteins". Annual Review of Medicine. 38: 175–194. doi:10.1146/annurev.me.38.020187.001135. ISSN 0066-4219. PMID 3555290.

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案内

案内

lymphocyte function-associated antigen-1