lumiracoxib

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2012/09/18 15:41:11」(JST)

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英文文献

  • Network Meta-Analysis Comparing Relatively Selective COX-2 Inhibitors Versus Coxibs for the Prevention of NSAID-Induced Gastrointestinal Injury.
  • Yang M1, Wang HT, Zhao M, Meng WB, Ou JQ, He JH, Zou B, Lei PG.
  • Medicine.Medicine (Baltimore).2015 Oct;94(40):e1592. doi: 10.1097/MD.0000000000001592.
  • Currently 2 difference classes of cyclooxygenase (COX)-2 inhibitors, coxibs and relatively selective COX-2 inhibitors, are available for patients requiring nonsteroidal anti-inflammatory drug (NSAID) therapy; their gastroprotective effect is hardly directly compared.The aim of this study was to comp
  • PMID 26448006
  • Two-photon uncageable enzyme inhibitors bearing targeting vectors.
  • Anstaett P1, Pierroz V, Ferrari S, Gasser G.
  • Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology.Photochem Photobiol Sci.2015 Sep 30;14(10):1821-5. doi: 10.1039/c5pp00245a.
  • The activity of two cyclooxygenase-2 enzyme inhibitors, Celecoxib and Lumiracoxib, could be suppressed by coupling to photo-labile protecting groups, so-called photocages. These groups could be further functionalized with a peptide targeting vector for specific cellular delivery. The enzyme inhibiti
  • PMID 26314377
  • Action at a distance: mutations of peripheral residues transform rapid reversible inhibitors to slow, tight binders of cyclooxygenase-2.
  • Blobaum AL1, Xu S1, Rowlinson SW1, Duggan KC1, Banerjee S2, Kudalkar SN1, Birmingham WR1, Ghebreselasie K1, Marnett LJ3.
  • The Journal of biological chemistry.J Biol Chem.2015 May 15;290(20):12793-803. doi: 10.1074/jbc.M114.635987. Epub 2015 Mar 30.
  • Cyclooxygenase enzymes (COX-1 and COX-2) catalyze the conversion of arachidonic acid to prostaglandin G2. The inhibitory activity of rapid, reversible COX inhibitors (ibuprofen, naproxen, mefenamic acid, and lumiracoxib) demonstrated a significant increase in potency and time dependence of inhibitio
  • PMID 25825493

和文文献

  • Inhibitory Effect of Selective Cyclooxygenase-2 Inhibitor Lumiracoxib on Human Organic Anion Transporters hOAT1 and hOAT3
  • UWAI Yuichi,HONJO Hiroaki,IWAMOTO Kikuo
  • Drug metabolism and pharmacokinetics 25(5), 450-455, 2010-10-25
  • NAID 10027583731
  • 新規非ステロイド性抗炎症薬 lumiracoxib のCOX-2選択的阻害作用の検討
  • 古家 英寿,村上 眞,松隈 京子,月川 洋,木村 美由紀,石橋 元規,宍戸 晃,入江 伸
  • 臨床薬理 = JAPANESE JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS 35(1), 181S, 2004-01-31
  • NAID 10012890290
  • Comparison of lumiracoxib with naproxen and ibuprofen in the Therapeutic Arthritis Research and Gastrointestinal Event Trial (TARGET), reduction in ulcer complications : randomised controlled trial

関連リンク

Read more about the pharmacogenomics of lumiracoxib on PharmGKB. ... Lumiracoxib has a different structure from the standard COX-2 inhibitors (e.g. celecoxib). It more closely resembles the structure of diclofenac (one chlorine ...
Identification Name Lumiracoxib Accession Number DB01283 Type Small Molecule Groups Approved, Investigational Description Lumiracoxib is a COX-2 selective inhibitor non-steroidal anti-inflammatory drug. On August 11, 2007 ...

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lumiracoxib
非ステロイド性抗炎症薬
  • コキシブ系非ステロイド性抗炎症薬;COX-2選択的阻害




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