an impairment of health or a condition of abnormal functioning
of or relating to or near the part of the back between the ribs and the hipbones; "lumbar vertebrae"
caused by or altered by or manifesting disease or pathology; "diseased tonsils"; "a morbid growth"; "pathologic tissue"; "pathological bodily processes" (同)morbid, pathologic, pathological
Lumbar disc disease is the drying out of the spongy interior matrix of an intervertebral disc in the spine. Many physicians and patients use the term lumbar disc disease to encompass several different causes of back pain or sciatica. In this article, the term is used to describe a lumbar herniated disc. It is thought that lumbar disc disease causes about one-third of all back pain.
Contents
1Symptoms
2Genetics
3Diagnosis
4Treatment
5See also
6References
7External links
Symptoms
Pain, loss of muscle strength and loss of touch sensation may occur if this herniation causes the compression of the most proximal part of the nerve closely neighbouring the intervertebral disc material. Pain is in the distribution of the nerve compressed, usually down the back of the leg, side of the calf and inside of the foot (sciatica). Most commonly, the nerve root between the fourth and fifth lumbar vertebrae or between the fifth lumbar vertebra and first sacral segment are impinged.
In symptomatic cases the diagnosis should be confirmed by an MRI scan. However, in cases with slight symptoms, a faster and cheaper CT scan (although it is inferior to MRI scan) may be recommended. While a CT scan can show the bony structures in more detail, an MRI scan can better portray soft tissue.
Genetics
An inheritable gene variation may cause increased susceptibility. People with a variation in a gene that encodes the cartilage intermediate-layer protein (CILP) were 1.6 times more likely to have the disease than persons without the variation.[1] CILP is a normal component of disc tissue. The gene variant was hypothesized to disrupt normal building and maintenance of cartilage. However, this association was not replicated in a follow-up study of Finnish and Chinese individuals.[2]
Diagnosis
Diagnosis can be made on clinical basis with MRI findings
Treatment
Initial treatment in lumbar disc disease is one or two days of bedrest (although growing number of studies shows that it makes little difference) and pain relieving medications. In cases with ongoing pain despite conservative treatments, a surgical operation that will remove the compressing disc material, a microdiscectomy or discectomy may be recommended to treat a lumbar disc herniation.
See also
Degenerative disc disease
Sciatica
Spinal disc herniation
Lumbar spinal stenosis
References
^Seki, S; Kawaguchi, Y; Chiba, K; Mikami, Y; Kizawa, H; Oya, T; Mio, F; Mori, M; Miyamoto, Y; Masuda, I; Tsunoda, T; Kamata, M; Kubo, T; Toyama, Y; Kimura, T; Nakamura, Y; Ikegawa, S (2005). "A functional SNP in CILP, encoding cartilage intermediate layer protein, is associated with susceptibility to lumbar disc disease". Nature Genetics. 37 (6): 607–12. doi:10.1038/ng1557. PMID 15864306.
^Virtanen, I. M.; Song, Y. Q.; Cheung, K. M.; Ala-Kokko, L; Karppinen, J; Ho, D. W.; Luk, K. D.; Yip, S. P.; Leong, J. C.; Cheah, K. S.; Sham, P; Chan, D (2007). "Phenotypic and population differences in the association between CILP and lumbar disc disease". Journal of Medical Genetics. 44 (4): 285–8. doi:10.1136/jmg.2006.047076. PMC 2598035. PMID 17220213.
Seki S, Andrews C, Kawaguchi Y, Chiba K, Mikami Y, Kizawa H, Oya T, Mio F, Mori M, Miyamoto Y, Masuda I, Tsunoda T, Kamata M, Kubo T, Toyama Y, Kimura T, Nakamura Y, Ikegawa S (2005). "A functional SNP in CILP, encoding cartilage intermediate layer protein, is associated with susceptibility to lumbar disc disease". Nature Genetics. 37 (6): 607–612. doi:10.1038/ng1557. PMID 15864306.
External links
E-medicine - Lumbar disc disease
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… compresses the descending S1 nerve root. Lumbardisc herniation at the L1 level is rare, and thus L1 radiculopathy is uncommon. Symptoms on presentation generally involve pain, paresthesia, and sensory loss …
…deficits, improves outcomes for lumbardisc prolapse with radiculopathy or symptomatic spinal stenosis . The presence of mild foot drop or other minor motor deficits due to lumbardisc prolapse with radiculopathy …
…compared with other active treatments alone . Serious adverse events following lumbar spinal manipulation (such as worsening lumbardisc herniation or cauda equina syndrome) are possible but rare. Studies of …
…symptomatic lumbardisc herniation is to relieve symptoms due to compression or inflammation of affected nerve roots. The surgery involves either partial or complete removal of the herniated disc. The utility …
…are acquired with ≤3 mm collimation (typically ≤1 mm collimation) from the skull base through C7-T1 disc space. Thin-slice (≤1 mm) axial images in bone algorithm are preferred for primary evaluation in the … If a cervical spine fracture is detected, the entire spinal column (ie, cervical, thoracic, and lumbar spine), in general, is imaged. Fractures found at one level of the spine are associated with injury …
English Journal
Does the presence of the fibronectin-aggrecan complex predict outcomes from lumbar discectomy for disc herniation?
The spine journal : official journal of the North American Spine Society.Spine J.2019 Feb;19(2):e28-e33. doi: 10.1016/j.spinee.2013.06.064. Epub 2013 Nov 13.
Structural characteristics and predicted functional capacities of epaxial muscles in chondrodystrophic and non-chondrodystrophic dogs with and without suspected intervertebral disc herniation- a preliminary study.
… Lumbar spinal disease is one of the"locomotive syndrome". … Most common disease for advancedpeople is lumbar spinal canal stenosis（LSCS）, on the other hand, most common disease for youngadult people is lumbardisc herniation（LDH）. …
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