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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/02/11 21:57:40」(JST)

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Loteprednol (as the ester loteprednol etabonate) is a corticosteroid used in ophthalmology. Marketed by Bausch and Lomb as Lotemax in the U.S., ocular applications for this drug include the treatment of inflammation of the eye due to allergies (according to the prescription information sheet), as well as chronic forms of keratitis (e.g.: adenoviral and Thygeson’s keratitis), vernal keratoconjunctivitis, pingueculitis, and episcleritis. The drug has little or no effect on intraocular pressure.

References

Steward, R; et al. (November 1998). "Double-masked, placebo-controlled evaluation of loteprednol etabonate 0.5% for postoperative inflammation". J Cataract Surg 24: 1480–1489.
Pavesio, CE; Decory, HH (2008). "Treatment of ocular inflammatory conditions with loteprednol etabonate". Br J Ophthalmol 92 (4): 455–459. doi:10.1136/bjo.2007.132621. PMID 18245274.

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1. シェーグレン症候群におけるドライアイの治療 treatment of dry eyes in sjogrens syndrome
2. 眼性酒さ ocular rosacea
3. 巨大乳頭結膜炎 giant papillary conjunctivitis
4. アレルギー性結膜炎：マネージメント allergic conjunctivitis management
5. 春季カタル vernal keratoconjunctivitis

English Journal

Topical loteprednol etabonate 0.5 % for treatment of vernal keratoconjunctivitis: efficacy and safety.

Oner V, Türkcü FM, Taş M, Alakuş MF, Işcan Y.SourceDepartment of Ophthalmology, Batman State Hospital, Batman, Turkey, veysioner@gmail.com.
Japanese journal of ophthalmology.Jpn J Ophthalmol.2012 Jul;56(4):312-8. Epub 2012 May 25.
PURPOSE: To evaluate the efficacy and safety of loteprednol etabonate (LE) 0.5 % in vernal keratoconjunctivitis (VKC) patients compared to prednisolone and fluorometholone.METHODS: The patients were randomized into three groups: the loteprednol group, prednisolone group and fluorometholone group. M
PMID 22622345

Loteprednol etabonate ophthalmic suspension 0.5 %: efficacy and safety for postoperative anti-inflammatory use.

Amon M, Busin M.SourceDepartment of Ophthalmology, Hospital of the Brothers of Charity, Johannes von Gott Platz 1, 1020, Vienna, Austria, michael.amon@bbwien.at.
International ophthalmology.Int Ophthalmol.2012 Jun 16. [Epub ahead of print]
Topical corticosteroids are routinely used as postoperative ocular anti-inflammatory drugs; however, adverse effects such as increased intraocular pressure (IOP) are observed with their use. While older corticosteroids such as dexamethasone and prednisolone acetate offer good anti-inflammatory effic
PMID 22707339

Japanese Journal

Topical loteprednol etabonate 0.5% for treatment of vernal keratoconjunctivitis : efficacy and safety

Oner Veysi,Turkcu Fatih Mehmet,Tas Mehmet [他],ALAKUS Mehmet Fuat,ISCAN Yalcm
Japanese journal of ophthalmology 56(4), 312-318, 2012-07-01
NAID 10030951915

Effect of loteprednol etabonate nasal spray suspension on seasonal allergic rhinitis assessed by allergen challenge in an environmental exposure unit

KRUG N
Allergy 60, 354-359, 2005
NAID 30013415282

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★リンクテーブル★

リンク元	「ロテプレドノール」「エタボン酸ロテプレドノール」
関連記事	「loteprednol」

「ロテプレドノール」

Loteprednol etabonate
Systematic (IUPAC) name
	Chloromethyl 17-ethoxycarbonyloxy-11-hydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-17-carboxylate
Clinical data
AHFS/Drugs.com	Micromedex Detailed Consumer Information
MedlinePlus	a606003
Pregnancy; category	US: C;
Legal status	US: ℞-only;
Identifiers
CAS number	82034-46-6
ATC code	S01BA14
PubChem	CID 444025
DrugBank	DB00873
ChemSpider	392049
UNII	Z8CBU6KR16
KEGG	D01689
ChEMBL	CHEMBL1201389
Chemical data
Formula	C24H31ClO7
Molecular mass	466.951 g/mol
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