関: loteprednol etabonate

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/02/18 23:01:45」(JST)

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Loteprednol (as the ester loteprednol etabonate) is a corticosteroid used in ophthalmology. Marketed by Bausch and Lomb as Lotemax in the U.S., ocular applications for this drug include the treatment of inflammation of the eye due to allergies (according to the prescription information sheet), as well as chronic forms of keratitis (e.g.: adenoviral and Thygeson’s keratitis), vernal keratoconjunctivitis, pingueculitis, and episcleritis. The drug has little or no effect on intraocular pressure.

References

Steward, R; et al. (November 1998). "Double-masked, placebo-controlled evaluation of loteprednol etabonate 0.5% for postoperative inflammation". J Cataract Surg 24: 1480–1489.
Pavesio, CE; Decory, HH (2008). "Treatment of ocular inflammatory conditions with loteprednol etabonate". Br J Ophthalmol 92 (4): 455–459. doi:10.1136/bjo.2007.132621. PMID 18245274.

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1. アレルギー性結膜炎：マネージメント allergic conjunctivitis management
2. シェーグレン症候群におけるドライアイの治療 treatment of dry eyes in sjogrens syndrome
3. 春季カタル vernal keratoconjunctivitis
4. 巨大乳頭結膜炎 giant papillary conjunctivitis
5. 眼性酒さ ocular rosacea

English Journal

Expert opinion in the management of aqueous Deficient Dry Eye Disease (DED).

Sy A1,2, O'Brien KS3, Liu MP4, Cuddapah PA5, Acharya NR6,7, Lietman TM8,9, Rose-Nussbaumer J10,11.
BMC ophthalmology.BMC Ophthalmol.2015 Oct 13;15(1):133. doi: 10.1186/s12886-015-0122-z.
BACKGROUND: Dry eye disease (DED) affects millions of people worldwide. There are a variety of new treatments beyond traditional therapies such as preservative free artificial tears. Here, we conduct a survey to identify the most common treatments used among specialists and assess their interest in
PMID 26462481

Design, characterization and in vitro evaluation of novel shell crosslinked poly(butylene adipate)-co-N-succinyl chitosan nanogels containing loteprednol etabonate: A new system for therapeutic effect enhancement via controlled drug delivery.

Nasr FH1, Khoee S2.
European journal of medicinal chemistry.Eur J Med Chem.2015 Sep 18;102:132-42. doi: 10.1016/j.ejmech.2015.07.045. Epub 2015 Aug 1.
This study reports on the development of a novel mucoadhesive and biocompatible shell-crosslinked nanogel system based on poly(butylene adipate) (PBA) and N-succinyl chitosan (S-Cs) by coupling reaction with a new formulation method. For this purpose, two different molecular weights of dendrimerized
PMID 26263245

Corneal Confocal Microscopy in Dry Eye Treated with Corticosteroids.

Villani E1, Garoli E, Termine V, Pichi F, Ratiglia R, Nucci P.
Optometry and vision science : official publication of the American Academy of Optometry.Optom Vis Sci.2015 Sep;92(9):e290-5. doi: 10.1097/OPX.0000000000000600.
PURPOSE: To evaluate, by in vivo laser scanning confocal microscopy (LSCM), the corneal findings in moderate-to-severe dry eye patients before and after treatment with topical corticosteroid and to associate the confocal findings to the clinical response.METHODS: Fifty eyes of 50 patients with moder
PMID 25909241

Japanese Journal

Topical loteprednol etabonate 0.5% for treatment of vernal keratoconjunctivitis : efficacy and safety

Oner Veysi,Turkcu Fatih Mehmet,Tas Mehmet [他],ALAKUS Mehmet Fuat,ISCAN Yalcm
Japanese journal of ophthalmology 56(4), 312-318, 2012-07-01
NAID 10030951915

Effect of loteprednol etabonate nasal spray suspension on seasonal allegic rhinitis assessed by allergen challenge in an environmental exposure unit

KRUG N
Allergy 60, 354-359, 2005
NAID 30013415282

「ロテプレドノール」

Loteprednol etabonate
Systematic (IUPAC) name
	Chloromethyl 17-ethoxycarbonyloxy-11-hydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-17-carboxylate
Clinical data
AHFS/Drugs.com	Micromedex Detailed Consumer Information
MedlinePlus	a606003
Pregnancy; category	US: C (Risk not ruled out); ;
Legal status	US: ℞-only;
Identifiers
CAS Number	82034-46-6
ATC code	S01BA14
PubChem	CID 444025
IUPHAR/BPS	7085
DrugBank	DB00873
ChemSpider	392049
UNII	Z8CBU6KR16
KEGG	D01689
ChEMBL	CHEMBL1201389
Chemical data
Formula	C24H31ClO7
Molar mass	466.951 g/mol
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