loop diuretics

出典: meddic

ループ利尿薬

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英文文献

  • A sea urchin Na(+)K(+)2Cl(-) cotransporter is involved in the maintenance of calcification-relevant cytoplasmic cords in Strongylocentrotus droebachiensis larvae.
  • Basse WC1, Gutowska MA1, Findeisen U2, Stumpp M2, Dupont S3, Jackson DJ4, Himmerkus N1, Melzner F2, Bleich M5.
  • Comparative biochemistry and physiology. Part A, Molecular & integrative physiology.Comp Biochem Physiol A Mol Integr Physiol.2015 Sep;187:184-92. doi: 10.1016/j.cbpa.2015.05.005. Epub 2015 May 15.
  • The cellular mechanisms of calcification in sea urchin larvae are still not well understood. Primary mesenchyme cells within the larval body cavity form a syncytium to secrete CaCO3 spicules from intracellular amorphous CaCO3 (ACC) stores. We studied the role of Na(+)K(+)2Cl(-) cotransporter (NKCC)
  • PMID 25986441
  • Inhibitors of the renal outer medullary potassium channel: a patent review.
  • Martelli A1, Testai L, Breschi MC, Calderone V.
  • Expert opinion on therapeutic patents.Expert Opin Ther Pat.2015 Sep;25(9):1035-51. doi: 10.1517/13543776.2015.1050792. Epub 2015 May 26.
  • INTRODUCTION: Hypertension represents a substantial cardiovascular risk factor. Among anti-hypertensive drugs, diuretics play an important role. Nevertheless, they present adverse effects such as hypokalemia or hyperkalemia. In this panorama, inhibitors of the renal outer medullary potassium (ROMK)
  • PMID 26004420
  • Outcomes of heart failure with preserved ejection fraction in a Southeast Asian cohort.
  • Hoong CW1, Lim CP, Gao F, Chen Q, Kawa LB, Ching CK, Sim DK.
  • Journal of cardiovascular medicine (Hagerstown, Md.).J Cardiovasc Med (Hagerstown).2015 Sep;16(9):583-90. doi: 10.2459/JCM.0000000000000100.
  • BACKGROUND: Heart failure with preserved ejection fraction (HF-PEF) has been shown to be of better or equivalent prognosis than heart failure with reduced ejection fraction (HF-REF). We aimed to characterize and study the outcome of HF-PEF in a multiethnic South East Asian context.METHODS: This is a
  • PMID 25022929

和文文献

  • Risk factors for colistin-associated acute kidney injury: a multicenter study from Turkey
  • Gul Serdar,Kuscu Ferit,Aydemir Hande,Ozturk Dogan Baris,Deveci Ozcan,Duygu Fazilet,Kacmaz Birgul,Yaman Ferda,Aslan Emel
  • Japanese Journal of Infectious Diseases advpub(0), 2015
  • … Results of the Cox regression analysis indicated that concomitant use of loop diuretics, baseline creatinin level and CMS dosage were independently associated with AKI. … According to our results, patients with higher baseline creatinin levels or patients who have to use concomitant loop diuretics may be monitored more closely and dose adjustment should be done promptly. …
  • NAID 130005086980
  • Improved Long-Term Prognosis of Dilated Cardiomyopathy With Implementation of Evidenced-Based Medication – Report From the CHART Studies –
  • Ushigome Ryoichi,Sakata Yasuhiko,Nochioka Kotaro [他],Miyata Satoshi,Miura Masanobu,Tadaki Soichiro,Yamauchi Takeshi,Sato Kenjiro,Onose Takeo,Tsuji Kanako,Abe Ruri,Takahashi Jun,Shimokawa Hiroaki,on behalf of the CHART-2 Investigators
  • Circulation Journal 79(6), 1332-1341, 2015
  • … The use of β-blockers and aldosterone antagonists was significantly increased, while that of loop diuretics and digitalis was significantly decreased in the CHART-2 Study. …
  • NAID 130005073161
  • Improved Long-Term Prognosis of Dilated Cardiomyopathy With Implementation of Evidenced-Based Medication – Report From the CHART Studies –
  • Ushigome Ryoichi,Sakata Yasuhiko,Nochioka Kotaro,Miyata Satoshi,Miura Masanobu,Tadaki Soichiro,Yamauchi Takeshi,Sato Kenjiro,Onose Takeo,Tsuji Kanako,Abe Ruri,Takahashi Jun,Shimokawa Hiroaki,on behalf of the CHART-2 Investigators
  • Circulation Journal advpub(0), 2015
  • … The use of β-blockers and aldosterone antagonists was significantly increased, while that of loop diuretics and digitalis was significantly decreased in the CHART-2 Study. …
  • NAID 130005063504

関連リンク

関連画像

Ch 26: Diuretic Meds at Midwestern Loop diuretics abolish cortico medullary Hypertension at Medical University of Diureticsimage fig_15-4_ion_transport_pathways for Hypochloremic Metabolic Alkalosis


★リンクテーブル★
リンク元ループ利尿薬」「overzealous
関連記事loop」「diuretic」「lo」「loo」「loops

ループ利尿薬」

  [★]

loop diuretic, loop diuretics
利尿薬
sodium-potassium-chloride symporter inhibitor

概念

  • Henleループに作用する強力な利尿薬の一群

種類 (SP.790)

作用機序

  • 太いヘンレの上行脚において、Na+-K+-2Cl-共輸送体を抑制→ 同部位におけるNaCl再吸収の抑制

血清電解質の変化

  Na K Cl H Ca Mg
血清  

副作用

GOO.752
  • Na喪失 → K+,H+喪失:
  • 過剰の投与によりナトリウムを喪失 → 低ナトリウム血症、細胞外液量減少 → 低血圧、GFR低下、循環虚脱、血栓塞栓の発生、(肝臓疾患が存在する場合)肝性脳症
  • 過剰のナトリウムが遠位尿細管に到達する結果、(特にRAA系が体液喪失のために亢進していると)カリウムと水素イオンの排泄が亢進し、低Cl性アルカローシス(代謝性アシドーシス)を生じる。
  • もともと体内にKが欠乏していれば、不整脈が誘発される。特に強心配糖体を摂取していれば顕著となる(ジギタリス中毒)。
  • Mg,Ca喪失
  • 骨粗鬆症を呈する閉経女性への投与は、骨代謝を悪化させうる。
  • その他:耳毒性(難聴眩暈耳鳴)、高尿酸血症、高血糖、LDL上昇、TG上昇、HDL低下、皮疹、光過敏性、錯感覚、骨髄抑制、胃腸症状

禁忌

臨床関連



overzealous」

  [★]

  • adj.
  • あまりに熱心な
overzealous use of loop diuretics can cause serious depletion of total-body Na+.(GOO.752)

loop」

  [★]

  • n.
ansaringwheel

WordNet   license wordnet

「move in loops; "The bicycle looped around the tree"」

WordNet   license wordnet

「anything with a round or oval shape (formed by a curve that is closed and does not intersect itself)」

WordNet   license wordnet

「a flight maneuver; aircraft flies a complete circle in the vertical plane」
loop-the-loop

WordNet   license wordnet

「an intrauterine device in the shape of a loop」

WordNet   license wordnet

「a computer program that performs a series of instructions repeatedly until some specified condition is satisfied」

WordNet   license wordnet

「an inner circle of advisors (especially under President Reagan); "he''s no longer in the loop"」

WordNet   license wordnet

「the basic pattern of the human fingerprint」

PrepTutorEJDIC   license prepejdic

「(糸・ひも・針金などで作った)『輪』・輪状のもの;(輪状の)湾曲部・(宙返り飛行・スケートなどで描く)輪・ループ (ある条件が成立するまで繰り返し実行される,プログラム中に記述された一連の命令のこと)・仲間、影響}を受け合う間柄・同列の立場・「keep誰々in the loop」として、「keep誰々informed:情報を(人)に絶えず提供し続ける、報告を(人)に欠かさない、(人)に逐次連絡する、(人)に常に通知する」・避妊リング; (鉄道・電線などの)環状線(loop line)・…‘を'輪にする,輪で囲む・…‘を'輪で結ぶ,輪で締める《+『up』+『名,』+『名』+『up』》・輪になる,輪を描く」

WordNet   license wordnet

「make a loop in; "loop a rope"」
intertwine

WordNet   license wordnet

「fasten or join with a loop; "He looped the watch through his belt"」

WordNet   license wordnet

「fly loops, perform a loop; "the stunt pilot looped his plane"」

diuretic」

  [★] 利尿薬 diuretics

PrepTutorEJDIC   license prepejdic

「排尿促進の,利尿の / 利尿剤」


lo」

  [★]

PrepTutorEJDIC   license prepejdic

「見よ,そら」


loo」

  [★]

PrepTutorEJDIC   license prepejdic

「便所」


loops」

  [★]

protein conformation




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