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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/02/20 19:47:58」(JST)

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  • Is it prime time for alpha2-adrenocepter agonists in the treatment of withdrawal syndromes?
  • Albertson TE1, Chenoweth J, Ford J, Owen K, Sutter ME.
  • Journal of medical toxicology : official journal of the American College of Medical Toxicology.J Med Toxicol.2014 Dec;10(4):369-81. doi: 10.1007/s13181-014-0430-3.
  • The need to treat withdrawal syndromes is a common occurrence in outpatient, inpatient ward, and intensive care unit (ICU) settings. A PubMed and Google Scholar search using alpha2-adrenoreceptor agonist (A2AA), specific A2AA agents, withdrawal syndrome and nicotine, and alcohol and opioid withdrawa
  • PMID 25238670
  • The preclinical discovery of lofexidine for the treatment of opiate addiction.
  • Vartak AP1.
  • Expert opinion on drug discovery.Expert Opin Drug Discov.2014 Nov;9(11):1371-7. doi: 10.1517/17460441.2014.962995. Epub 2014 Sep 26.
  • INTRODUCTION: Lofexidine is one therapeutic option used for treating the onslaught of sympathetic outflow that typically commences upon induction of opiate withdrawal. It was approved for opiate detoxification in the UK, most of EU, and a select few countries worldwide during the 1980s and the 90s.
  • PMID 25260380
  • Dual effects of α2 -adrenoceptors in modulating myogenic tone in sheep isolated internal anal sphincter.
  • Rayment SJ1, Simpson JA, Eames T, Acheson AG, Dashwood MR, Henry Y, Gruss H, Scholefield JH, Wilson VG.
  • Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.Neurogastroenterol Motil.2014 Aug;26(8):1095-103. doi: 10.1111/nmo.12363. Epub 2014 Jun 6.
  • BACKGROUND: The role of α-adrenoceptors in promoting continence through modulation of sphincter tone has focused primarily on the effects of α1 -adrenoceptors. We have used three clinically available agents, which are selective for α2 -adrenoceptors, to investigate their role in contractile and n
  • PMID 24906134


  • Lofexidine for opiate detoxification : Review of recent randamised and open controlled trials


Lofexidine Lofexidine Systematic ( IUPAC ) name ( RS )-2-[1-(2,6-dichlorophenoxy)ethyl]-4,5-dihydro-1 H -imidazole Clinical data AHFS / Drugs.com International ... Indication In the United Kingdom, the hydrochloride form, lofexidine ...
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