同: LCIS

WordNet

serve in a specific professional capacity; "the priest sat for confession"; "she sat on the jury"
be around, often idly or without specific purpose; "The object sat in the corner"; "We sat around chatting for another hour" (同)sit around
be seated (同)sit_down
be in session; "When does the court of law sit?"
be located or situated somewhere; "The White House sits on Pennsylvania Avenue"
holding office; "the in party"
to or toward the inside of; "come in"; "smash in the door" (同)inwards, inward
currently fashionable; "the in thing to do"; "large shoulder pads are in"
directed or bound inward; "took the in bus"; "the in basket"
any malignant tumor derived from epithelial tissue; one of the four major types of cancer
of or relating to or resembling a lobule

PrepTutorEJDIC

(…に)『座る』,座っている《+『at』(『on, in』)+『名』》・着席する《+『down』》・(…に)〈鳥などが〉『止まる』,休む《+『on』+『名』》・〈めんどりが〉卵を抱く,巣に就く / 《場所の副詞[句]を伴って》(ある場所に)『位置する』・ (画家・写真家のために)ポーズをとる・しっとしている,動かないでいる・(議員・委員などの)職に就いている《+『on』+『名』》・〈議会・法廷などが〉開会(開廷)される・(…に)負担となる,重荷となる《+『on』(『upon』)+『名』》・〈衣服などが〉(…に)合う,似合う《+『on』+『名』》・〈人〉‘を'座らせる,着席させる《+『down』+『名,』+『名』+『down』》・〈馬〉‘に'乗る・《英》〈試験〉‘を'受ける
《具体的な場所,位置》 / …『の中に』(『で』) / …『において』,…で / 《intoの代りに移動を表す動詞と共に》…『の中へ』 / (乗り物)『に乗って』 / …『の状熊に』(『で』) / …『に従事して』,に属して / …『を身につけて』,に覆われて / 《『in』do『ing』の形で》…『するときに』,する際に(when) / 《時間》 / …『して』,…『が経過したあと』 / …『の間に』 / …『については』,…の点では / 《方法・手段・材料》…『で』 / 《人を目的語にして,性質・能力があることを示して》…の中に / …の目的で,のつもりで,として / 《比率割合》…のうちで,につき / 《過去分詞に伴って》…に[…されて] / 『中へ』(に) / 『在宅して』,帰って / (乗り物などが)『到着して』,(時期・季節が)来て / 出回って,流行して / 《俗》流行の,当世風の / 《話》特定の人々にのみ理解される
がん,がん腫
あり場所,位置 / (部分・器官の)正常な位置,原位置

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/09/05 14:16:07」(JST)

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[Wiki en表示]

Lobular carcinoma in situ (LCIS) is a condition caused by unusual cells in the lobules of the breast.^[1]

Many do not consider it cancer, and many do, but all agree it can indicate an increased risk of future cancer.^[2]^[3]^[4] The national database registrars, however, consider LCIS a malignancy. Malignancy of course is cancer. ^[5]

Unlike ductal carcinoma in situ (DCIS), LCIS is not associated with calcification, and is typically an incidental finding in a biopsy performed for another reason. LCIS only accounts for about 15% of the in situ (ductal or lobular) breast cancers.^[6]

Genetics

Cells of LCIS and invasive lobular carcinoma have the same histology, appearing as single detached cells, as both have loss of expression of e-cadherin, the transmembrane protein mediating epithelial cell adhesion.^[7] LCIS often have the same genetic alterations (such as loss of heterozygosity on chromosome 16q, the locus for the e-cadherin gene) as the adjacent area of invasive carcinoma.^[8]

Morphology

Lobular carcinoma in situ, H&E, 20x

Like the cells of atypical lobular hyperplasia and invasive lobular carcinoma, the abnormal cells of LCIS consist of small cells with oval or round nuclei and small nucleoli detached from each other.^[9] Mucin-containing signet-ring cells are commonly seen. LCIS generally leaves the underlying architecture intact and recognisable as lobules. Estrogen and progesterone receptors are present and HER2/neu overexpression is absent in most cases of LCIS.^[9]

Treatment options

LCIS may be treated with close clinical follow-up and mammographic screening, tamoxifen, or related hormone controlling drugs to reduce the risk of developing cancer, or bilateral prophylactic mastectomy. Some surgeons consider bilateral prophylactic mastectomy to be overly aggressive treatment except for certain high-risk cases. Risk may be accelerated by the presence of dense breast tissue, which obscures rate of spread. ^[10]

Prognosis

LCIS (lobular neoplasia is considered pre-cancerous) is an indicator (marker) identifying women with an increased risk of developing invasive breast cancer. This risk extends more than 20 years. Most of the risk relates to subsequent invasive ductal carcinoma rather than to invasive lobular carcinoma.^[10]

While older studies have shown that the increased risk is equal for both breasts, a more recent study suggests that the ipsilateral (same side) breast may be at greater risk.^[11]

References

^ "Lobular Carcinoma in situ (LCIS)". Breast Cancer. Stanford Cancer Center.
^ "Lobular carcinoma in situ: Marker for breast cancer risk". MayoClinic.com.
^ "Breast Cancer Treatment". National Cancer Institute.
^ Afonso N, Bouwman D (August 2008). "Lobular carcinoma in situ". Eur. J. Cancer Prev. 17 (4): 312–6. doi:10.1097/CEJ.0b013e3282f75e5d. PMID 18562954.
^ Cancer, American Joint Committee on (2002). AJCC cancer staging handbook : from the AJCC cancer staging manual (6th ed.). New York: Springer. p. 260. ISBN 9780387952703.
^ "Susan G. Komen for the Cure | Understanding Breast Cancer | Breast Facts | Statistics | Breast Cancer Statistics". Retrieved 2013-01-16.
^ Hajra KM, Fearon ER (2002). "Cadherin and catenin alterations in human cancer". Genes Chromosomes Cancer. 34 (3): 255–68. doi:10.1002/gcc.10083. PMID 12007186.
^ Lakhani SR (2001). "Molecular genetics of solid tumors: translating research into clinical practice. What we could do now: breast cancer". Mol Pathol. 54 (5): 281–4. doi:10.1136/mp.54.5.281. PMC 1187082. PMID 11577167.
^ ^a ^b Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. (2005). Robbins and Cotran pathologic basis of disease (7th ed.). St. Louis, MO: Elsevier Saunders. p. 1142. ISBN 0-7216-0187-1.
^ ^a ^b "Breast Cancer Treatment (PDQ®) - National Cancer Institute - Lobular Carcinoma In Situ". Retrieved 2013-01-12.
^ Page DL, Schuyler PA, DuPont WD, Jensen RA, Plummer WD Jr, Simpson JF (2003). "Atypical lobular hyperplasia as a unilateral predictor of breast cancer risk: a retrospective cohort study". Lancet. 361 (9352): 125–9. doi:10.1016/S0140-6736(03)12230-1. PMID 12531579.

UpToDate Contents

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1. 異型および上皮内小葉癌：乳癌のハイリスク病変 atypia and lobular carcinoma in situ high risk lesions of the breast
2. 非浸潤性乳管癌：疫学、臨床症状、および診断 breast ductal carcinoma in situ epidemiology clinical manifestations and diagnosis
3. 乳癌の病理 pathology of breast cancer
4. 非浸潤性乳管癌：治療および予後 ductal carcinoma in situ treatment and prognosis
5. 微小浸潤乳癌 microinvasive breast carcinoma

English Journal

Second harmonic generation reveals matrix alterations during breast tumor progression.

Burke K, Tang P, Brown E.SourceUniversity of Rochester, Department of Biomedical Engineering, Rochester, NY 14627, USA.
Journal of biomedical optics.J Biomed Opt.2013 Mar;18(3):31106. doi: 10.1117/1.JBO.18.3.031106.
Alteration of the extracellular matrix in tumor stroma influences efficiency of cell locomotion away from the primary tumor into surrounding tissues and vasculature, thereby affecting metastatic potential. We study matrix changes in breast cancer through the use of second harmonic generation (SHG) o
PMID 23172133

Pre-operative factors indicating risk of multiple operations versus a single operation in women undergoing surgery for screen detected breast cancer.

O'Flynn EA, Currie RJ, Mohammed K, Allen SD, Michell MJ.SourceDepartment of Radiology, Royal Marsden NHS Foundation Trust, Downs Road, Sutton, Surrey SM2 5PT, United Kingdom. Electronic address: lizoflynn@doctors.org.uk.
Breast (Edinburgh, Scotland).Breast.2013 Feb;22(1):78-82. doi: 10.1016/j.breast.2012.06.011. Epub 2012 Jul 10.
We aim to identify preoperative factors at diagnosis which could predict whether women undergoing wide local excision (WLE) would require further operations. 1593 screen-detected invasive and non-invasive breast cancers were reviewed. Age, presence of ductal carcinoma in situ (DCIS), invasive cancer
PMID 22789490

Japanese Journal

症例術前穿刺細胞診にて異なる細胞所見を呈した同側同時多発乳癌の1例

神奈川県臨床細胞学会誌 20(1), 57-62, 2015-08
NAID 40020951277

乳腺葉状腫瘍内に非浸潤性乳管癌と非浸潤性小葉癌が併存した1例

日本臨床外科学会雑誌 76(4), 693-698, 2015
NAID 130005106535

Clonal profiling of mixed lobular and ductal carcinoma revealed by multiplex ligation-dependent probe amplification and fluorescence in situ hybridization

Pathology International 64(5), 231-236, 2014-05
NAID 120005463366

Related Pictures

★リンクテーブル★

リンク元	「非浸潤性小葉癌」「非浸潤性小葉がん」「LCIS」
関連記事	「sit」「in situ」「lobular」「lobula」「situ」

「非浸潤性小葉癌」

Lobular carcinoma in situ
	Diagram showing localized and invasive LCIS
Classification and external resources
Specialty	oncology
ICD-10	D05.0
ICD-O	M8520/2
	[edit on Wikidata]