クエン酸リチウム
WordNet
- a soft silver-white univalent element of the alkali metal group; the lightest metal known; occurs in several minerals (同)Li, atomic number 3
- a salt or ester of citric acid
- cause to form a salt or ester of citric acid
PrepTutorEJDIC
- リチウム(金属元素;化学記号は『Li』)
- クエン酸塩
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2019/01/20 10:52:55」(JST)
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Lithium citrate
Names
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Other names
Trilithium citrate trilithium 2-hydroxypropane-1,2,3-tricarboxylate
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Identifiers
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CAS Number
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3D model (JSmol)
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ChEMBL
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ChemSpider
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ECHA InfoCard
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100.011.860
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RTECS number
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TZ8616000
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InChI
InChI=1S/C6H8O7.3Li/c7-3(8)1-6(13,5(11)12)2-4(9)10;;;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);;;/q;3*+1/p-3 Y Key: WJSIUCDMWSDDCE-UHFFFAOYSA-K Y InChI=1/C6H8O7.3Li/c7-3(8)1-6(13,5(11)12)2-4(9)10;;;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);;;/q;3*+1/p-3 Key: WJSIUCDMWSDDCE-DFZHHIFOAV
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SMILES
[Li+].[Li+].[Li+].O=C([O-])CC(O)(C([O-])=O)CC(=O)[O-]
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Properties
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Chemical formula
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Li3C6H5O7
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Molar mass
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209.923 g mol−1
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Appearance
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Odorless white powder
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Melting point
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decomposes at 105 °C (221 °F; 378 K)
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Hazards
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Main hazards
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Toxic
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R-phrases (outdated)
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R22 R36 R37 R38
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Flash point
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N/A
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Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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N verify (what is YN ?)
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Infobox references
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Lithium citrate (Li3C6H5O7) is a chemical compound of lithium and citrate that is used as a mood stabilizer in psychiatric treatment of manic states and bipolar disorder[1][2]. There is extensive pharmacology of lithium, the active component of this salt.
Lithia water contains various lithium salts, including the citrate. An early version of Coca-Cola available in pharmacies' soda fountains called Lithia Coke was a mixture of Coca-Cola syrup and lithia water. The soft drink 7Up was originally named "Bib-Label Lithiated Lemon-Lime Soda" when it was formulated in 1929 because it contained lithium citrate. The beverage was a patent medicine marketed as a cure for hangover. Lithium citrate was removed from 7Up in 1948.[3]
References
- ^ Medication description
- ^ Medical use Archived 2006-06-15 at the Wayback Machine.
- ^ Gielen, Marcel; Edward R. T. Tiekink (2005). Metallotherapeutic drugs and metal-based diagnostic agents: The use of metals in medicine. John Wiley and Sons. p. 3. ISBN 0-470-86403-6.
Mood stabilizers |
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Anticonvulsants |
- Carbamazepine
- Lamotrigine
- Oxcarbazepine
- Valproate
- Valnoctamide
- Valproate pivoxil
- Valpromide
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Atypical antipsychotics |
- Aripiprazole
- Cariprazine
- Clozapine
- Lurasidone
- Olanzapine (+fluoxetine)
- Paliperidone
- Quetiapine
- Risperidone
- Ziprasidone
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Others |
- Ketamine
- Lithium (lithium acetate, lithium carbonate, lithium chloride, lithium citrate, lithium hydroxide, lithium orotate)
- Omega-3 fatty acids (docosahexaenoic acid, eicosapentaenoic acid)
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Lithium compounds |
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Inorganic |
- LiAlCl4
- LiAlH4
- LiAlO2
- LiBF4
- LiBH4
- LiBO2
- LiB3O5
- Li2B4O7
- LiBr
- Li2CO3
- Li2C2
- LiCl
- LiClO
- LiClO3
- LiClO4
- LiCoO2
- LiF
- LiH
- LiI
- LiIO3
- Li2IrO3
- Li2MoO4
- LiNH2
- Li2NH
- LiN3
- Li3N
- LiNO2
- LiNO3
- LiNbO3
- LiOH
- LiO2
- Li2O
- Li2O2
- LiPF6
- Li2PtO3
- Li2Po
- Li2RuO3
- Li2S
- Li2SO3
- Li2SO4
- Li3H(CO3)2
- Li2SiO3
- LiTaO3
- Li2TiO3
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Organic |
- 12-hydroxystearate
- acetate
- aspartate
- citrate
- diisopropylamide
- orotate
- succinate
- stearate
- organolithiums
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Minerals |
- Amblygonite
- Elbaite
- Eucryptite
- Jadarite
- Lepidolite
- Lithiophilite
- Petalite
- Pezzottaite
- Saliotite
- Spodumene
- Sugilite
- Tourmaline
- Zabuyelite
- Zinnwaldite
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UpToDate Contents
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English Journal
- Lithium citrate as treatment of Canavan disease.
- Solsona MD, Fernández LL, Boquet EM, Andrés JL.SourceDepartment of Pharmacy, Hospital Universitari i Politècnic La Fe, Valencia, Spain. edo_marsol@gva.es
- Clinical neuropharmacology.Clin Neuropharmacol.2012 May;35(3):150-1. doi: 10.1097/WNF.0b013e3182515c9d.
- Canavan disease is a rare autosomal recessive leukodystrophy characterized by abnormal accumulation of N-acetyl aspartate (NAA) in brain white matter. Currently, there is no cure for this disease, and management of patients consists mainly of treating symptoms. We describe a 3-month-old girl who was
- PMID 22592512
- A computerised sampling strategy for therapeutic drug monitoring of lithium provides precise estimates and significantly reduces dose-finding time.
- Hoegberg LC, Jürgens G, Zederkof VW, Holgersson B, Andersson JE, Dalhoff KP, Larsen EB, Angelo HR.SourceDepartment of Clinical Biochemistry, Bispebjerg University Hospital, Bispebjerg Bakke 23, Copenhagen, Denmark. LHOE0021@bbh.regionh.dk
- Basic & clinical pharmacology & toxicology.Basic Clin Pharmacol Toxicol.2012 Mar;110(3):259-63. doi: 10.1111/j.1742-7843.2011.00800.x. Epub 2011 Nov 15.
- The clinical benefit of implementing Bayesian approach for lithium drug monitoring was evaluated. Intervention group (N = 42) and historical control group (N = 55) patients were each divided into two groups: Dosage with immediate-release lithium carbonate or a sustained-release formulation,
- PMID 21933347
- Treating PIK3CA and EGFR overexpressing breast cancers with lithium citrate.
- Brand TM, Wheeler DL.SourceDepartment of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
- Cancer biology & therapy.Cancer Biol Ther.2011 Feb 1;11(3):368-70. Epub 2011 Feb 1.
- PMID 21228636
Japanese Journal
- 硫酸,硝酸およびクエン酸を用いたコバルト酸リチウムの水熱酸浸出
- Synthesis of porous LiFePO<sub>4</sub> cathode material by citrate process for lithium ion battery
- 健常者のリチウム摂取量と血清リチウム濃度 : 血液分析に及ぼす試薬中の不純物リチウム
- Biomedical research on trace elements 16(3), 250-257, 2005-10-01
- NAID 10017070742
Related Links
- Lithium citrate (Li3C6H5O7) is a chemical compound of lithium and citrate that is used as a mood stabilizer in psychiatric treatment of manic states and bipolar disorder. For the medical aspects of lithium citrate, see lithium pharmacology.
- Each 5 mL of Lithium Citrate Syrup, USP contains 8 mEq of lithium ion (Li+), equivalent to the amount of lithium in 300 mg of lithium carbonate and alcohol 0.3 % v/v. Lithium is an element of the alkali-metal group with atomic number 3, atomic ...
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