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「an ACE inhibiting drug (trade names Prinival or Zestril) administered as an antihypertensive and after heart attacks」
Prinival, Zestril

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/06/23 09:31:39」(JST)

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  • The cough reflex is upregulated by lisinopril microinjected into the caudal nucleus tractus solitarii of the rabbit.
  • Cinelli E1, Bongianni F1, Pantaleo T1, Mutolo D2.
  • Respiratory physiology & neurobiology.Respir Physiol Neurobiol.2015 Dec;219:9-17. doi: 10.1016/j.resp.2015.07.013. Epub 2015 Jul 30.
  • We have previously shown that cough potentiation induced by intravenous administration of the AT1 receptor antagonist losartan is lower than that induced by the ACE inhibitor lisinopril in anesthetized and awake rabbits. Since losartan and lisinopril cross the blood-brain barrier, their central acti
  • PMID 26234277
  • Automated Outreach for Cardiovascular-Related Medication Refill Reminders.
  • Harrison TN1, Green KR2, Liu IA1, Vansomphone SS3, Handler J4, Scott RD5, Cheetham TC1, Reynolds K1.
  • Journal of clinical hypertension (Greenwich, Conn.).J Clin Hypertens (Greenwich).2015 Nov 6. doi: 10.1111/jch.12723. [Epub ahead of print]
  • The objective of this study was to evaluate the effectiveness of an automated telephone system reminding patients with hypertension and/or cardiovascular disease to obtain overdue medication refills. The authors compared the intervention with usual care among patients with an overdue prescription fo
  • PMID 26542896
  • Treating hypertension in hemodialysis improves symptoms seemingly unrelated to volume excess.
  • Agarwal R1.
  • Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.Nephrol Dial Transplant.2015 Nov 5. pii: gfv371. [Epub ahead of print]
  • BACKGROUND: Among hemodialysis patients, probing dry weight is an effective strategy for improving control of hypertension. Whether controlling hypertension improves or worsens symptoms among such patients remains unclear. The purpose of the study was to develop a tool to evaluate symptoms and exami
  • PMID 26546591


  • Lercanidipine Rescues Hippocampus Pyramidal Neurons from Mild Ischemia-Induced Delayed Neuronal Death in SHRSP.
  • Sakurai-Yamashita Yasuko,Harada Noboru,Niwa Masami
  • Cellular and molecular neurobiology 31(4), 561-567, 2011-05
  • … This study was designed to compare the effects of the antihypertensive drugs lercanidipine, nicardipine, lisinopril, valsartan, and hydralazine on occlusion-induced DND in SHRSPs. … Hydralazine and lisinopril were associated with the greatest reduction; …
  • NAID 120002835141
  • Complete remission of non-HIV collapsing glomerulopathy with deflazacort and lisinopril in an adult patient
  • VEGA Jorge,GUARDA Francisco Javier,GOECKE Helmuth,MENDEZ Gonzalo P.
  • Clinical and experimental nephrology 14(4), 385-388, 2010-08-01
  • NAID 10027706925


Lisinopril is used to treat hypertension, congestive heart failure and to improve survival after a heart attack. Learn about side effects, interactions and indications. ... Lisinopril side effects Get emergency medical help if you have any of ...
The reference site for lisinopril including news articles, images, and updated information ... What is Lisinopril? Lisinopril is in a class of drugs called angiotensin-converting-enzyme (ACE) inhibitors. This medicine is used to lower ...


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angiotensin-converting enzyme inhibitor angiotensin converting enzyme inhibitor , ACE inhibitor, ACEI
アンジオテンシン変換酵素阻害剤 アンギオテンシン変換酵素阻害薬 アンギオテンシン変換酵素阻害剤 アンジオテンシン転換酵素阻害薬ACE阻害薬 ACE阻害剤 ACE inhibitor、アンギオテンシン変換酵素拮抗薬, アンギオテンシン変換酵素拮抗薬, angiotensin-converting enzyme antagonist
アンジオテンシン, アンジオテンシン転換酵素 ACE, 1型アンジオテンシンII受容体拮抗薬 アンジオテンシンII受容体拮抗薬 ARB


薬剤名 成分名 高血圧 腎性高血圧 腎血管性高血圧 悪性高血圧 慢性心不全 1型糖尿病に伴う糖尿病性腎症
レニベース エナラプリル  
ロンゲス リシノプリル        
タナトリル イミダプリル      
エースコール テモカプリル      
コバシル ペリンドプリル           


  • 咳嗽:ACEブラジキニンを分解するキニナーゼIIと同一の酵素である。ACE阻害薬はこの酵素を阻害するが、ブラジキニンは血管拡張、血漿滲出、発痛作用に関わっている。このため咳を誘発することがある。
  • 高カリウム血症:間接的に血漿中のレニン濃度が低下するためにナトリウム取り込みとカリウム排泄が低下して高カリウム血症を来す
  • 低血圧
  • 腎不全


  • 妊婦
  • 両側性腎動脈狭窄のある患者
  • 腎血流量の減少や糸球体ろ過圧の低下により急速に腎機能を悪化させるおそれ。アンジオテンシンIIによる輸出細動脈の収縮作用がblockされ、両腎共に腎血流が減少しているためにGFRの低下を代償できず腎機能の悪化をきたす。