lipohyalinosis

脂肪硝子変性、リ・ヒアリノーシス

同

類線維素壊死

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/03/28 00:26:57」(JST)

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Lipohyalinosis is a small-vessel disease in the brain. Originally defined by Fisher as 'segmental arteriolar wall disorganisation', it is characterised by vessel wall thickening and a resultant reduction in luminal diameter. Fisher considered this small-vessel disease to be the result of hypertension, induced in the acute stage by fibrinoid necrosis that would lead to occlusion and hence lacunar stroke. However, recent evidence suggests that endothelial dysfunction as a result of inflammation is a more likely cause for it. This may occur subsequent to blood–brain barrier failure, and lead to extravasation of serum components into the brain that are potentially toxic. Lacunar infarction could thus occur in this way, and the narrowing – the hallmark feature of lipohyalinosis – may merely be a feature of the swelling occurring around it that squeezes on the structure.

Hypertension is a strong causative factor. So-called deep-perforating arteries – relatively small arteries branching off of relatively large arteries (most commonly the lenticulostriate arteries from the middle cerebral artery) – are especially prone. Uncontrolled hypertension and diabetes are risk factors for this condition. Lacunar infarcts are a result of atherosclerosis (microthrombi) and lipohyalinosis. These affect the deep structures of the brain and may leave small (~5mm) cavity lesions.

Chronic familial lipohyalinosis is a rare inherited variant.

References

UpToDate Contents

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• 1. ラクナ梗塞 lacunar infarcts
• 2. 脳卒中の病因、分類、および疫学 etiology classification and epidemiology of stroke
• 3. Definition, etiology, and clinical manifestations of transient ischemic attack
• 4. 一過性脳虚血発作および脳卒中の鑑別診断 differential diagnosis of transient ischemic attack and stroke
• 5. 脳卒中評価の概要 overview of the evaluation of stroke

English Journal

• Risk factors for lacune subtypes in the Atherosclerosis Risk in Communities (ARIC) Study.

• Bezerra DC, Sharrett AR, Matsushita K, Gottesman RF, Shibata D, Mosley TH Jr, Coresh J, Szklo M, Carvalho MS, Selvin E.Sourcedanielcbezerra@gmail.com
• Neurology.Neurology.2012 Jan 10;78(2):102-8. Epub 2011 Dec 14.
• OBJECTIVE: Lacunar infarctions are mainly due to 2 microvascular pathologies: lipohyalinosis and microatheroma. Little is known about risk factor differences for these subtypes. We hypothesized that diabetes and glycated hemoglobin (HbA(1)c) would be related preferentially to the lipohyalinotic subt
• PMID 22170882

• Lenticulostriate infarction.

• Decavel P, Vuillier F, Moulin T.SourceService de Neurologie, CHU Besançon, Besançon, France.
• Frontiers of neurology and neuroscience.Front Neurol Neurosci.2012;30:115-9. Epub 2012 Feb 14.
• Lenticulostriate infarcts result from ischemia within the territory supplied by the deep perforating branches of the middle cerebral artery (MCA). They are too often associated with infarctions of the deep perforating branches of the internal carotid artery. Lenticulostriate arteries usually arise f
• PMID 22377876

Japanese Journal

• ラクナ梗塞 ラクナ梗塞の臨床病型分類--病型と責任病巣 (インターベンション時代の脳卒中学(改訂第2版)(下)超急性期から再発予防まで) -- (脳梗塞)

• 山本 康正
• 日本臨床 64(-) (903), 139-143, 2006-11
• NAID 40015171806

• ラクナ梗塞における凝固・線溶活性 : lipohyalinosis型小径ラクナとアテローム型大径ラクナの差違

• 山本 康正,大岩 海陽,林 正道,今井 啓輔,中村 智実
• 臨床神経学 39(11), 1104-1108, 1999-11-01
• NAID 10008326238

Related Links

• Lipohyalinosis - Wikipedia, the free encyclopedia

Lipohyalinosis is a small-vessel disease in the brain. Originally defined by Fisher as 'segmental arteriolar wall disorganisation', it is characterised by vessel wall thickening and a resultant reduction in luminal diameter. Fisher considered this ...

• Pathology of small vessel stroke - British Medical Bulletin

Lipohyalinosis, as originally described, is a destructive vessel lesion ... The term ' lipohyalinosis' has subsequently been misused to describe ... 'lipohyalinosis' (' complex' small vessel disease) in the putamen of an elderly woman with multiple ...

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「脂肪硝子変性」

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lipohyalinosis

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リ・ヒアリノーシス

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英

lipohyalinosis

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脂肪硝子変性