ligand-binding activity

• リガンド結合活性

WordNet

1. executed with proper legal authority; "a binding contract"
2. the protective covering on the front, back, and spine of a book; "the book had a leather binding" (同)book binding, cover, back
3. strip sewn over or along an edge for reinforcement or decoration
4. the capacity to attract and hold something
5. any specific behavior; "they avoided all recreational activity"
6. (chemistry) the capacity of a substance to take part in a chemical reaction; "catalytic activity"
7. a substance (an atom or molecule or radical or ion) that forms a complex around a central atom

PrepTutorEJDIC

1. 義務的な,拘束力ある / 〈U〉しばること;〈C〉しばる物 / 〈C〉製本,装丁 / 〈U〉縁(‘ふち')取り材料
2. 〈U〉『活動』,働き;活力 / 《しばしば複数形で》(種々の)『活動』,行事;(学生の)学内(外)活動,クラブ活動 / 〈U〉(商況・市場などの)活発,活気

UpToDate Contents

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• 1. 乳癌におけるホルモン受容体：臨床的有用性および検査精度向上のためのガイドラインの推奨 hormone receptors in breast cancer clinical utility and guideline recommendations to improve test accuracy
• 2. プロテインＳ欠乏症 protein s deficiency
• 3. 非転移性初期乳癌の予後と予後予測因子 prognostic and predictive factors in early nonmetastatic breast cancer
• 4. 性行為に伴う一次性頭痛 primary headache associated with sexual activity
• 5. 臨床試験および臨床における関節リウマチの活動性の評価 assessment of rheumatoid arthritis activity in clinical trials and clinical practice

English Journal

• CRISPR knock out CTLA-4 enhances the anti-tumor activity of cytotoxic T lymphocytes.

• Shi L1, Meng T2, Zhao Z3, Han J4, Zhang W5, Gao F6, Cai J7.
• Gene.Gene.2017 Dec 15;636:36-41. doi: 10.1016/j.gene.2017.09.010. Epub 2017 Sep 6.
• PMID 28888577

• Rational screening of peroxisome proliferator-activated receptor-γ agonists from natural products: potential therapeutics for heart failure.

• Chen R1, Wan J1, Song J1, Qian Y1, Liu Y1, Gu S2.
• Pharmaceutical biology.Pharm Biol.2017 Dec;55(1):503-509.
• PMID 27937122

• P2Y12 antibody inhibits platelet activity and protects against thrombogenesis.

• Hensch NR1, Karim ZA2, Pineda J1, Mercado N1, Alshbool FZ2, Khasawneh FT3.
• Biochemical and biophysical research communications.Biochem Biophys Res Commun.2017 Nov 18;493(2):1069-1074. doi: 10.1016/j.bbrc.2017.09.083. Epub 2017 Sep 18.
• PMID 28928091

Japanese Journal

• 球状疎水性ファーマコフォアを有する非セコステロイド型VDRリガンドの創製研究

• 藤井 晋也,棚谷 綾,平野 智也,影近 弘之
• ビタミン 88(8), 389-395, 2014-08-25
• … The carborane-based VDR ligands exhibited significant vitamin D activity, comparable to that of the natural hormone, despite its simple structure with flexible skeletal chains. … On the other hand, bicyclo[2.2.2]octane derivatives exhibited quite low activity in comparison to the corresponding carborane derivatives. …
• NAID 110009843773

• Effect of Ca²⁺ on the activity and structure of α-glucosidase : Inhibition kinetics and molecular dynamics simulations

• Zhang Xin,Shi Long,Li Xuan [他],Sheng Qing,Yao Ling,Shen Dong,Lu Zhi-Rong,Zhou Hai-Meng,Park Yong-Doo,Lee Jinhyuk,Zhang Qian
• Journal of bioscience and bioengineering 117(6), 696-705, 2014-06
• … We found that direct binding of Ca^<2+> … to the enzyme induced structural changes and inhibited enzyme activity. … binding sites are associated with the structural changes in α-glucosidase. … Our study provides insight into the mechanism of the Ca^<2+>-induced structural changes in α-glucosidase and the inhibition of ligand binding. …
• NAID 110009823153

• Mechanism of Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) Transactivation by Hesperetin Glucuronides Is Distinct from That by a Thiazolidine-2,4-dione Agent

• Gamo Kanae,Shiraki Takuma,Matsuura Nobuyasu,Miyachi Hiroyuki
• Chemical and Pharmaceutical Bulletin 62(5), 491-493, 2014
• … Hesperidin, a flavanone glycoside present abundantly in citrus fruits, is predominantly metabolized to hesperetin-7-O-β-<span style="font-variant: small-caps;">D</span>-glucuronide (H7-OG) and hesperetin-3′-O-β-<span style="font-variant: small-caps;">D</span>-glucuronide (H3′-OG), which exhibit partial agonistic activity towards peroxisome proliferator-activated receptor gamma (PPARγ). …
• NAID 130004053794

Related Links

• Effect of nitric oxide on the ligand-binding activity of albumin.

1. Arch Biochem Biophys. 1997 Sep 15;345(2):237-42. Effect of nitric oxide on the ligand-binding activity of albumin. Kashiba-Iwatsuki M(1), Miyamoto M, Inoue M. Author information: (1)Department of Biochemistry, Osaka ...

• Potentiation of the ligand-binding activity of integrin α3β1 via ...

These results raised the possibility that the association of integrin α3β1 with CD151 potentiates the ligand-binding activity of the integrin through sustaining its activated conformation. In support of this cell adhesion laminin 3–5 3, 7 ...

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★リンクテーブル★

リンク元	「リガンド結合活性」
関連記事	「binding」「activity」

「リガンド結合活性」

　　[★]

英

ligand-binding activity

「binding」

　　[★]

• n.

• 結合、バインディング

• adj.

• 結合性の

関

affinity、associate、bind、bond、bonding、combine、conjoin、conjugate、conjugation、conjunction、connect、connection、connective、connectivity、couple、dock、engage、engagement、join、ligate、linkage、symphysial、symphysic、union

　 　 　 　 　

「activity」

　　[★]

• n.

• 活性、活性度、活動、活動性、活量

関

active