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a salt or ester of maleic acid; used as a nontricyclic antidepressant drug for psychomotor activation

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1. 癌患者における精神学的障害のマネージメント management of psychiatric disorders in patients with cancer
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Quantitative determination of phenothiazine derivatives in human plasma using monolithic silica solid-phase extraction tips and gas chromatography-mass spectrometry.

Kumazawa T1, Hasegawa C, Uchigasaki S, Lee XP, Suzuki O, Sato K.
Journal of chromatography. A.J Chromatogr A.2011 May 6;1218(18):2521-7. doi: 10.1016/j.chroma.2011.02.070. Epub 2011 Mar 4.
Solid-phase extraction (SPE) using micropipette tips is a useful technique to prepare samples prior to mass spectrometry. However, most commercial SPE tips have loading capacities that are insufficient for quantitative determination. In this paper, we describe a rapid method for quantitative microan
PMID 21429493

Effects of therapeutic agents on cellular respiration as an indication of metabolic activity.

Ishikawa T1, Zhu BL, Maeda H.
Human & experimental toxicology.Hum Exp Toxicol.2006 Mar;25(3):135-40.
Animal experiments are indispensable in the investigation of the toxicity of drugs on cells, but may not be preferred for ethical reasons and sensitivity. As an alternative procedure, we investigated the susceptibility of cells to drugs using the effect on cellular respiration as an indicator of cel
PMID 16634332

Hosomi K1, Okuno A, Umetani Y, Araya T, Matsuyama K, Haginaka J, Mifune M, Saito Y.
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.Yakugaku Zasshi.2004 Sep;124(9):587-98.
We studied the color change of phenothiazines and metal-containing drugs after compound formation, followed by use of FT-Raman spectrocopy to observe any structural changes in them. When 6 phenothiazines (thioridazine hydrochloride, prochlorperazine maleate, levomepromazine maleate, chlorpromazine p
PMID 15340180