leuprolide

出典: meddic

ロイプロリド

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/11/10 05:06:42」(JST)

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英文文献

  • Effects of chemical castration on sex offenders in relation to the kinetics of serum testosterone recovery: implications for dosing schedule.
  • Koo KC1, Ahn JH, Hong SJ, Lee JW, Chung BH.Author information 1Department of Urology and Urological Science Institute, Yonsei University College of Medicine, Seoul, Korea.AbstractINTRODUCTION: A growing number of countries are adopting chemical castration as treatment and penalty for sex offenders.
  • The journal of sexual medicine.J Sex Med.2014 May;11(5):1316-24. doi: 10.1111/jsm.12492. Epub 2014 Feb 27.
  • INTRODUCTION: A growing number of countries are adopting chemical castration as treatment and penalty for sex offenders.AIM: The aim of this study is to evaluate the outcome of chemical castration of sexual offenders with a focus on the kinetics of serum testosterone (T) recovery.METHODS: This prosp
  • PMID 24571582
  • Detection and effects on serum and urine steroid and LH of repeated GnRH analog (leuprolide) stimulation.
  • Handelsman DJ1, Idan A2, Grainger J3, Goebel C3, Turner L2, Conway AJ4.Author information 1Andrology Department, Concord Hospital, Sydney, NSW 2139, Australia; ANZAC Research Institute, University of Sydney, Sydney, NSW 2139, Australia. Electronic address: djh@anzac.edu.au.2Andrology Department, Concord Hospital, Sydney, NSW 2139, Australia.3Australian Sports Drug Testing Laboratory, National Measurement Institute, Sydney, NSW 2139, Australia.4Andrology Department, Concord Hospital, Sydney, NSW 2139, Australia; ANZAC Research Institute, University of Sydney, Sydney, NSW 2139, Australia.AbstractNon-steroidal drugs that increase endogenous testosterone (T) may be used to exploit ergogenic effects of androgens in power sports. While superactive GnRH analog use is suspected, neither screening nor detection tests are developed. This study aimed to determine if (a) stimulation for 5 days by leuprolide (a superactive GnRH analog) of serum and urine steroids and urine LH is reproducible at a 2 week interval, (b) nandrolone decanoate (ND) co-administration masks responses to leuprolide administration, (c) performance of urine measurement of leuprolide and M1, its major metabolite, as a detection test. Healthy men were randomized into a 4 week parallel group, open label clinical study in which all men had daily sc injections of leuprolide (1mg) for 4 days in the 1st and 3rd weeks with hormone-free 2nd and 4th weeks. In the 3rd week, men were randomized to either ND injections or no extra treatment. Serum steroids were determined by liquid chromatography, tandem mass spectrometry (LC-MS), urine steroids by gas chromatography, mass spectrometry (GC-MS), urine leuprolide and M1 by high resolution LC-MS and urine LH by immunoassay. Leuprolide stimulated striking, reproducible increases in serum and urine LH and steroids (serum T, dihydroT (DHT), 3α diol; urine T, epitestosterone (E) and androsterone (A). ND suppressed basal serum T, E2, 3α diol, and urinary E but did not mask or change the magnitude of responses to leuprolide. Urine leuprolide and M1 measurement had 100% sensitivity and specificity in detecting leuprolide administration up to one day after cessation of injections with the detection window between 1 and 3 days after last dose. Screening using urine steroid and LH measurements, optimally by urinary log10(LHxT), correctly classified 82% of urine samples. It is concluded that leuprolide stimulation of endogenous testosterone is reproducible after a 10-day interval, is not masked by ND and is reliably detected by urine leuprolide or M1 measurement for at least 1 day after administration.
  • The Journal of steroid biochemistry and molecular biology.J Steroid Biochem Mol Biol.2014 May;141:113-20. doi: 10.1016/j.jsbmb.2014.01.011. Epub 2014 Feb 2.
  • Non-steroidal drugs that increase endogenous testosterone (T) may be used to exploit ergogenic effects of androgens in power sports. While superactive GnRH analog use is suspected, neither screening nor detection tests are developed. This study aimed to determine if (a) stimulation for 5 days by leu
  • PMID 24495617
  • Unrecognized kinetics of serum testosterone: impact on short-term androgen deprivation therapy for prostate cancer.
  • Koo KC1, Lee DH2, Kim KH2, Lee SH2, Hong CH2, Hong SJ2, Chung BH2.Author information 1Department of Urology and Urological Science Institute, Yonsei University College of Medicine, Seoul, Korea. ; Sex Offender Treatment and Rehabilitation Center, National Forensic Hospital, Gongju, Korea.2Department of Urology and Urological Science Institute, Yonsei University College of Medicine, Seoul, Korea.AbstractPURPOSE: To evaluate the kinetics of serum testosterone (T) recovery following short-term androgen deprivation therapy (ADT), as the understanding thereof is essential for the proper management of prostate cancer (PCa), especially intermittent ADT.
  • Yonsei medical journal.Yonsei Med J.2014 May 1;55(3):570-5. doi: 10.3349/ymj.2014.55.3.570. Epub 2014 Apr 1.
  • PURPOSE: To evaluate the kinetics of serum testosterone (T) recovery following short-term androgen deprivation therapy (ADT), as the understanding thereof is essential for the proper management of prostate cancer (PCa), especially intermittent ADT.MATERIALS AND METHODS: This prospective analysis inc
  • PMID 24719121

和文文献

  • 経尿道的膀胱腫瘍切除術及びホルモン療法にて治療を行った膀胱子宮内膜症の1例
  • 小玉 美智子,平松 宏祐,金容 輝,奥野 健太郎,古元 淑子,伏見 博彰,竹村 昌彦
  • 日本産科婦人科内視鏡學會雜誌 = The journal of the Japan Endoscopy Society of Obstetrics and Gynecology 25(2), 395-398, 2009-12-01
  • … The administration of leuprolide acetate followed by genogest successfully reduced the tumor size and alleviated the symptoms for 14 months. …
  • NAID 10026519527
  • Comparison of the effects of cetrorelix, a GnRH antagonist, and leuprolide, a GnRH agonist, on experimental endometriosis
  • ALTINTAS Devrim,KOKCU Arif,TOSUN Migraci,CETINKAYA Mehmet B.,KANDEMIR Bedri
  • The journal of obstetrics and gynaecology research 34(6), 1014-1019, 2008-12-01
  • NAID 10023917711

関連リンク

癌,がん,ガン,化学療法,がん情報,放射線治療,米国国立がん研究所,抗がん剤 ... 【リニューアルのお知らせ】 「海外癌医療情報リファレンス」のウェブサイトは、2011年5月24日に全面リニューアルを行い、新サイトへ引越しました。
Leuprolide - Leuprolide is a man-made form of a hormone that regulates many processes in the body. Leuprolide overstimulates the body's own production of certain hormones, which causes that production to shut down temporarily.

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leuprolide
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leuprolide acetate
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Lupron
リュープロレリン leuprorelinロイプロリド leuprolide
  • 商品名
  • LH-RH作動薬;前立腺癌および閉経前乳癌治療;子宮内膜症治療
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