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Koryakina A1, Frey E2, Bruegger P3.
Journal of immunological methods.J Immunol Methods.2014 Mar;405:181-91. doi: 10.1016/j.jim.2014.01.005. Epub 2014 Jan 21.
EU Directive 2010/63/EU regarding the protection of experimental animals came into force in November 2010 with an obligation for EU member states to incorporate its requirements into their respective national legislations by 1st of January 2013. The directive stipulates the application of in vitro m
PMID 24456627

Evidence for the detection of non-endotoxin pyrogens by the whole blood monocyte activation test.

Hasiwa N1, Daneshian M, Bruegger P, Fennrich S, Hochadel A, Hoffmann S, Rivera-Mariani FE, Rockel C, Schindler S, Spreitzer I, Stoppelkamp S, Vysyaraju K, Hartung T.
ALTEX.ALTEX.2013;30(2):169-208.
Threats of pyrogenicity were discovered more than a century ago. Measures to determine the safety of parenterals and, more recently, medical devices and cell therapies for human use have been in place for 70 years. Currently, there are three testing possibilities available: the Rabbit Pyrogen Test,
PMID 23665806

Johnson Rowsey P.
Annual review of nursing research.Annu Rev Nurs Res.2013;31:19-46. doi: 10.1891/0739-6686.31.19.
The study of fever has provided important models in understanding the cells, chemical messengers, and anatomic structures that are involved in inflammation and thermoregulation as a result of infection, stress, or trauma. After contact with a pathogen or an inflammatory stimulus, cells are activated
PMID 24894136

前田悦子,植松利男
日本薬理学雑誌 98(6), 457-466, 1991
… alminoprofen(AP)の発熱に対する作用を，無麻酔下の発熱ウサギモデルを用いて検討した．発熱は，lipopolysaccharide(LPS)の静脈内投与，leukocytic pyrogen(LP)の大槽内投与およびarachidonic acid(AA)の大槽内投与により惹起した．また，LPS投与後の脳脊髄液中のAPおよびPGE<SUB>2</SUB>量を測定した．AP(3〜30mg/kg，p.o.)は，LPS(0.5beg/kg，i.v.)により惹起された発熱を用量依存的に抑制した(AP，ibuprofen，indomethacin，pranoprof …
NAID 130000758819

ITAMI TAKAFUMI,EMA MAKOTO,KANOH SEIZABURO
Journal of pharmacobio-dynamics 9(3), 271-275, 1986-03
… The mechanism of the antipyretic effect of indomethacin (IM) on fever induced by bacterial pyrogen (LPS, 0.2 μg/kg, i.v.), leukocytic pyrogen (LP, 2 ml/kg, i.v.) and 2,4-dinitrophenol (DNP, 20 mg/kg, i.m.) in male adult rabbits was studied. … The activity of endogenous pyrogen in serum after LPS injection was not suppressed by the injection of IM (10 mg/kg, i.v.). …
NAID 110003638190