白血球破砕性血管炎
WordNet
- inflammation of a blood vessel
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/04/26 19:45:16」(JST)
[Wiki en表示]
Cutaneous small-vessel vasculitis (also known as "Cutaneous leukocytoclastic angiitis,"[1] "Cutaneous leukocytoclastic vasculitis,"[1] "Cutaneous necrotizing venulitis,"[1] and "Hypersensitivity angiitis"[1]) is inflammation of small blood vessels (usually post-capillary venules in the dermis), characterized by palpable purpura.[2]:831[3] It is the most common vasculitis seen in clinical practice. Leukocytoclasis refers to the damage caused by nuclear debris from infiltrating neutrophils in and around the vessels.[4]
Subtypes of small-vessel vasculitis include:[2]:833–6
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- Henoch-Schönlein purpura
- Acute hemorrhagic edema of infancy
- Urticarial vasculitis
- Cryoglobulinemic vasculitis
- Erythema elevatum diutinum
- Granuloma faciale
Leukocytoclastic vasculitis
See also
- Skin lesion
- List of cutaneous conditions
References
- ^ a b c d Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 1-4160-2999-0.
- ^ a b James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0.
- ^ Lotti T, Ghersetich I, Comacchi C, Jorizzo JL (November 1998). "Cutaneous small-vessel vasculitis". J. Am. Acad. Dermatol. 39 (5 Pt 1): 667–87; quiz 688–90. doi:10.1016/S0190-9622(98)70039-8. PMID 9810883.
- ^ Harrison's Principles of Internal Medicine. 18th edition. Page 2798.
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Cutaneous vasculitis and other vascular-related cutaneous conditions (L95, 709.1)
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| Cutaneous vasculitis |
- Erythema elevatum diutinum
- Capillaritis
- Urticarial vasculitis
- Nodular vasculitis
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| Microvascular occlusion |
- Calciphylaxis
- Cryoglobulinemic purpura/Cryoglobulinemic vasculitis
- vascular coagulopathy: Livedoid vasculitis
- Livedoid dermatitis
- Perinatal gangrene of the buttock
- Malignant atrophic papulosis
- Sneddon's syndrome
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| Purpura |
- Nonthrombocytopenic purpura: Cryofibrinogenemic purpura
- Drug-induced purpura
- Food-induced purpura
- Henoch–Schönlein purpura
- Obstructive purpura
- Orthostatic purpura
- Purpura fulminans
- Purpura secondary to clotting disorders
- Purpuric agave dermatitis
- Pigmentary purpuric eruptions
- Solar purpura
- Traumatic purpura
- Waldenström hyperglobulinemic purpura
- Painful bruising syndrome
- ungrouped: Paroxysmal hand hematoma
- Postcardiotomy syndrome
- Deep vein thrombosis
- Superficial thrombophlebitis
- Mondor's disease
- Blueberry muffin baby
- Fibrinolysis syndrome
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| Systemic vasculitis |
- see Template:Systemic vasculitis
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| Vascular malformations |
- Arteriovenous malformation
- Bonnet–Dechaume–Blanc syndrome
- Cobb syndrome
- Parkes Weber syndrome
- Sinusoidal hemangioma
- lymphatic malformation
- Hennekam syndrome
- Aagenaes syndrome
- telangiectasia: Generalized essential telangiectasia
- Hereditary hemorrhagic telangiectasia
- Unilateral nevoid telangiectasia
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| Ulcer |
- Venous ulcer
- Arterial insufficiency ulcer
- Hematopoietic ulcer
- Neuropathic ulcer
- Acroangiodermatitis
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| Lymphedema |
- see Template:Lymphatic vessel disease
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Ungrouped
vascular-related
cutaneous conditions |
- Raynaud's phenomenon
- Thromboangiitis obliterans
- Erythromelalgia
- Septic thrombophlebitis
- Arteriosclerosis obliterans
- Bier spots/Marshall–White syndrome
- Cholesterol embolus
- Reactive angioendotheliomatosis
- Trousseau's syndrome
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Systemic vasculitis (M30–M31, 446)
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| Large vessel |
- Takayasu's arteritis
- Giant-cell arteritis
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| Medium vessel |
- Type III hypersensitivity
- Kawasaki disease
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| Small vessel |
| Pauci-immune |
- c-ANCA
- Granulomatosis with polyangiitis
- p-ANCA
- Churg-Strauss syndrome
- Microscopic polyangiitis
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| Type III hypersensitivity |
- Hypersensitivity vasculitis/Henoch–Schönlein purpura
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| Ungrouped |
- Acute hemorrhagic edema of infancy
- Cryoglobulinemic vasculitis
- Bullous small vessel vasculitis
- Cutaneous small-vessel vasculitis
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| Other |
- Goodpasture's syndrome
- Sneddon's syndrome
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Hypersensitivity and autoimmune diseases (279.5–6)
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Type I/allergy/atopy
(IgE) |
| Foreign |
- Atopic eczema
- Allergic urticaria
- Allergic rhinitis (Hay fever)
- Allergic asthma
- Anaphylaxis
- Food allergy
- common allergies include: Milk
- Egg
- Peanut
- Tree nut
- Seafood
- Soy
- Wheat
- Penicillin allergy
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| Autoimmune |
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Type II/ADCC
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| Foreign |
- Hemolytic disease of the newborn
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| Autoimmune |
| Cytotoxic |
- Autoimmune hemolytic anemia
- Immune thrombocytopenic purpura
- Bullous pemphigoid
- Pemphigus vulgaris
- Rheumatic fever
- Goodpasture's syndrome
- Guillain–Barré syndrome
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| "Type V"/receptor |
- Graves' disease
- Myasthenia gravis
- Pernicious anemia
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Type III
(Immune complex) |
| Foreign |
- Henoch–Schönlein purpura
- Hypersensitivity vasculitis
- Reactive arthritis
- Farmer's lung
- Post-streptococcal glomerulonephritis
- Serum sickness
- Arthus reaction
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| Autoimmune |
- Systemic lupus erythematosus
- Subacute bacterial endocarditis
- Rheumatoid arthritis
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Type IV/cell-mediated
(T cells) |
| Foreign |
- Allergic contact dermatitis
- Mantoux test
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| Autoimmune |
- Diabetes mellitus type 1
- Hashimoto's thyroiditis
- Multiple sclerosis
- Coeliac disease
- Giant-cell arteritis
- Postorgasmic illness syndrome
- Reactive arthritis
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| GVHD |
- Transfusion-associated graft versus host disease
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Unknown/
multiple |
| Foreign |
- Hypersensitivity pneumonitis
- Allergic bronchopulmonary aspergillosis
- Transplant rejection
- Latex allergy (I+IV)
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| Autoimmune |
- Sjögren's syndrome
- Autoimmune hepatitis
- Autoimmune polyendocrine syndrome
- Autoimmune adrenalitis
- Systemic autoimmune disease
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UpToDate Contents
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English Journal
- Revisiting clinical differences between hipersensitivity vasculitis and Henoch-Schönlein purpura in adults from a defined population.
- Calvo-Río V, Loricera J, Ortiz-Sanjuán F, Mata C, Martín L, Alvarez L, González-Vela MC, Rueda-Gotor J, González-López MA, Armesto S, Peiró E, Arias M, Pina T, González-Gay MA, Blanco R.Author information Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV, Santander, Spain. fiorelfa@hotmail.com.AbstractOBJECTIVES: Hypersensitivity vasculitis (HV) and Henoch-Schönlein purpura (HSP) are the most common entities included within the category of cutaneous vasculitis (CV). Palpable purpura and histological changes characterised by the presence of leukocytoclastic vasculitis are common in both conditions. Therefore, considerable overlap between them is often seen. It is especially true when the CV occurs in adults. To further establish clinical differences between these two conditions, in the present study we assessed the main clinical differences between HV and HSP in a wide and unselected series of adults with CV from a defined population. METHODS:We reviewed the clinical records of 297 consecutive adults (age >20 years) seen at a single centre between January 1975 and December 2012 that were classified as having HSP or HV according to the criteria proposed by Michel et al. (J Rheumatol 1992; 19: 721-8).
- Clinical and experimental rheumatology.Clin Exp Rheumatol.2014 Feb 11. [Epub ahead of print]
- OBJECTIVES: Hypersensitivity vasculitis (HV) and Henoch-Schönlein purpura (HSP) are the most common entities included within the category of cutaneous vasculitis (CV). Palpable purpura and histological changes characterised by the presence of leukocytoclastic vasculitis are common in both condition
- PMID 24528895
- The correlation between cutaneous IgM deposition and renal involvement in adult patients with Henoch-Schönlein purpura.
- Belli AA1, Dervis E2.Author information 1Haseki Training, Research Hospital, Department of Dermatology Adivar Caddesi Aksaray, 34096 Istanbul, Turkey.2Kafkas University, Kafkas Medical School, Department of Dermatology.AbstractBackground: Henoch-Schönlein purpura (HSP) is a systemic and immune complex-related leukocytoclastic vasculitis. A positive correlation has been found between IgM deposition along with IgA in skin lesions diagnosed by direct immunofluorescence (DIF) and renal involvement with HSP. Objectives: We sought to investigate the relationship between the systemic associations of the disease and the severity of the skin lesions, as well as the immune deposition findings of the lesional skin provided by DIF in patients with HSP. Materials & Methods: Between 2001 and 2012, 47 patients with HSP were investigated at our dermatology clinic. Epidemiologic data, laboratory findings, localizations of the palpable purpura, existence of bulla or necrosis in the skin lesions, accompanying systemic involvement, and DIF findings of skin biopsy specimens were recorded. Results: Of the 47 patients 22 were men and 25 were women (age range 16-88 years, mean 42.2). Among all cases with skin involvement, we found 22 (46.8%) articular involvement, 20 (42.6%) renal involvement and 12 (25.5%) gastrointestinal tract involvement. The frequency of bulla and/or necrosis in the skin lesions was significantly high in patients with gastrointestinal and renal involvement (p<0.05). The risk of renal involvement was significantly high in patients whose DIF examination revealed IgM deposition (p<0.05). No association was found between systemic involvement and IgG, complement 3 (C3) and fibrinogen deposition. Conclusion: Patients with HSP, having bullous and/or necrotic lesions and whose skin DIF investigations reveal IgM deposition along with IgA, should be surveyed for the risk of renal involvement.
- European journal of dermatology : EJD.Eur J Dermatol.2014 Feb 8. [Epub ahead of print]
- Background: Henoch-Schönlein purpura (HSP) is a systemic and immune complex-related leukocytoclastic vasculitis. A positive correlation has been found between IgM deposition along with IgA in skin lesions diagnosed by direct immunofluorescence (DIF) and renal involvement with HSP. Objectives: We so
- PMID 24509447
- Urticarial vasculitis and Schnitzler syndrome.
- Zuberbier HC, Maurer M.Author information Department of Dermatology and Allergy, Allergy Center, Charité-Universitätsmedizin Berlin, Charitéplatz 1, Berlin 10117, Germany. Electronic address: torsten.zuberbier@charite.de.AbstractBoth urticarial vasculitis and Schnitzler syndrome are serious diseases but a recently gained better understanding of their underlying pathomechanism allows better treatment options than only a decade ago.
- Immunology and allergy clinics of North America.Immunol Allergy Clin North Am.2014 Feb;34(1):141-7. doi: 10.1016/j.iac.2013.09.007. Epub 2013 Oct 25.
- Both urticarial vasculitis and Schnitzler syndrome are serious diseases but a recently gained better understanding of their underlying pathomechanism allows better treatment options than only a decade ago. Copyright © 2014 Elsevier Inc. All rights reserved.
- PMID 24262694
Japanese Journal
- 皮膚科的な視点からみた血管炎症候群 : 皮膚症状から発症機序まで
- 川上 民裕
- 日本臨床免疫学会会誌 = Japanese journal of clinical immunology 30(3), 156-164, 2007-06-28
- 一般に血管炎症候群の分野で，皮膚科が関連するのはChapel Hill Consensus Conferenceにおける小血管レベルの各疾患と中血管レベルの結節性多発動脈炎（特に皮膚型結節性多発動脈炎）である．過去に経験した血管炎症候群の症例を振り返り，その皮膚症状，特に病初期における，を検討した．まず，ANCA関連血管炎では，顕微鏡的多発血管炎でリベド症状，Churg-S …
- NAID 10019552848
- 症例 Infliximab使用中の関節リウマチ患者に生じたLeucocytoclastic Vasculitis
Related Links
- 1. Scand J Rheumatol. 2001;30(6):315-22. Leucocytoclastic vasculitis: an update for the clinician. Koutkia P, Mylonakis E, Rounds S, Erickson A. Leucocytoclastic vasculitis is a small vessel inflammatory disease mediated mostly by ...
- A condition that the horse owner can be forgiven for confusing with mud fever is leucocytoclastic vasculitis. Although not as common as heel mange it is seen frequently by vets. It affects only white parts of the lower limb and usually ...