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an improvement that makes something more agreeable (同)sweetening

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高揚,増進

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1. 固形腫瘍による軟髄膜転移の臨床的特徴および診断 clinical features and diagnosis of leptomeningeal metastases from solid tumors
2. 成人における急性脳脊髄播種 acute disseminated encephalomyelitis in adults
3. 二次性中枢神経系リンパ腫の臨床症状および診断 clinical presentation and diagnosis of secondary central nervous system lymphoma
4. 軟髄膜転移の治療（癌性髄膜炎） treatment of leptomeningeal metastases carcinomatous meningitis
5. 多発神経根症：脊柱管狭窄症、感染症、癌、および炎症性神経根症候群 polyradiculopathy spinal stenosis infectious carcinomatous and inflammatory nerve root syndromes

English Journal

A Systematic Approach to the Diagnosis of Suspected Central Nervous System Lymphoma.

Scott BJ, Douglas VC, Tihan T, Rubenstein JL, Josephson SA.AbstractCentral nervous system (CNS) lymphoma can present a diagnostic challenge. Currently, there is no consensus regarding what presurgical evaluation is warranted or how to proceed when lesions are not surgically accessible. We conducted a review of the literature on CNS lymphoma diagnosis (1966 to October 2011) to determine whether a common diagnostic algorithm can be generated. We extracted data regarding the usefulness of brain and body imaging, serum and cerebrospinal fluid (CSF) studies, ophthalmologic examination, and tissue biopsy in the diagnosis of CNS lymphoma. Contrast enhancement on imaging is highly sensitive at the time of diagnosis: 98.9% in immunocompetent lymphoma and 96.1% in human immunodeficiency virus-related CNS lymphoma. The sensitivity of CSF cytology is low (2%-32%) but increases when combined with flow cytometry. Cerebrospinal fluid lactate dehydrogenase isozyme 5, β2-microglobulin, and immunoglobulin heavy chain rearrangement studies have improved sensitivity over CSF cytology (58%-85%) but have only moderate specificity (85%). New techniques of proteomics and microRNA analysis have more than 95% specificity in the diagnosis of CNS lymphoma. Positive CSF cytology, vitreous biopsy, or brain/leptomeningeal biopsy remain the current standard for diagnosis. A combined stepwise systematic approach outlined here may facilitate an expeditious, comprehensive presurgical evaluation for cases of suspected CNS lymphoma.
JAMA neurology.JAMA Neurol.2013 Jan 14:1-9. doi: 10.1001/jamaneurol.2013.606. [Epub ahead of print]
Central nervous system (CNS) lymphoma can present a diagnostic challenge. Currently, there is no consensus regarding what presurgical evaluation is warranted or how to proceed when lesions are not surgically accessible. We conducted a review of the literature on CNS lymphoma diagnosis (1966 to Octob
PMID 23319132

Clinical and Radiological Predictors of Outcome for Murray Valley Encephalitis.

Speers DJ, Flexman J, Blyth CC, Rooban N, Raby E, Ramaseshan G, Benson S, Smith DW.SourceDepartment of Microbiology, PathWest Laboratory Medicine WA, Nedlands, Western Australia, Australia; School of Medicine and Pharmacology, University of Western Australia, Crawley, Western Australia, Australia; Department of Microbiology, PathWest Laboratory Medicine WA, Royal Perth Hospital, Perth, Western Australia, Australia; Princess Margaret Hospital for Children, Subiaco, Western Australia, Australia; School of Paediatrics and Child Health, University of Western Australia, Crawley, Western Australia, Australia; Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia; Department of Microbiology, PathWest Laboratory Medicine WA, Fremantle Hospital, Fremantle, Western Australia, Australia; Fremantle Hospital, Fremantle, Western Australia, Australia; School of Pathology and Laboratory Medicine, University of Western Australia, Crawley, Western Australia, Australia.
The American journal of tropical medicine and hygiene.Am J Trop Med Hyg.2013 Jan 7. [Epub ahead of print]
A review of the laboratory-confirmed cases of Murray Valley encephalitis (MVE) from Western Australia between 2009 and 2011 was conducted to describe the clinical, laboratory, and radiological features of the disease. The nine encephalitis patients presented with altered mental state and seizures, t
PMID 23296449

Japanese Journal

Focal Leptomeningeal Metastasis Following Curative Surgery for Lung Cancer : Case Report

TAKAHASHI Mayu,SOEJIMA Yoshiteru,YAMAMOTO Junkoh,SAITO Takeshi,NISHIZAWA Shigeru
Neurologia medico-chirurgica = 神経外科 51(3), 247-250, 2011-03-15
… Magnetic resonance (MR) imaging of the brain, taken 10 months after the curative surgery, disclosed focal enhancement along the right central sulcus. … She underwent open biopsy and the histological diagnosis was leptomeningeal metastasis from adenocarcinoma. …
NAID 10029137774

動眼神経麻痺，内耳神経麻痺で発症した肺癌による癌性髄膜症の1例

鈴木妙子,濱口俊一,神田響,須谷顕尚,久良木隆繁,礒部威
肺癌 51(6), 730-735, 2011
背景．脳神経症状を初発症状とした癌性髄膜症は非常にまれであるとされる．症例．89歳，男性．2007年秋より左難聴を自覚し，翌年1月より急激に悪化，右眼瞼下垂，眼痛も出現し，当院脳外科を紹介され受診した．頭部単純MRIで陳旧性脳梗塞と診断されたが，その後も右眼瞼下垂の進行と右眼球運動障害の出現を認め，Tolosa-Hunt syndromeの疑いでステロイド治療が開始された．しかしその後も症状は悪化 …
NAID 130001284831