leber hereditary optic neuropathy

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/05/02 17:47:51」(JST)

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  • Prevalence of the primary LHON mutations in Northern Finland associated with bilateral optic atrophy and tobacco-alcohol amblyopia.
  • Korkiamäki P, Kervinen M, Karjalainen K, Majamaa K, Uusimaa J, Remes AM.SourceDepartment of Ophthalmology, Institute of Clinical Medicine, University of Oulu and Clinical Research Center, Oulu University Hospital, Oulu, Finland Department of Neurology, Institute of Clinical Medicine, University of Oulu and Clinical Research Center, Oulu University Hospital, Oulu, Finland Department of Pediatrics, Institute of Clinical Medicine, University of Oulu and Clinical Research Center, Oulu University Hospital, Oulu, Finland Department of Neurology, Institute of Clinical Medicine, University of Eastern, Finland Department of Neurology, Kuopio University Hospital, Finland.
  • Acta ophthalmologica.Acta Ophthalmol.2012 Sep 12. doi: 10.1111/j.1755-3768.2012.02506.x. [Epub ahead of print]
  • Purpose:  Leber hereditary optic neuropathy (LHON) is regarded as the most common mitochondrial disease. We have previously reported comprehensive population-based epidemiological data on common mitochondrial DNA (mtDNA) mutations including m.3243A>G, m.8344A>G and large-scale mtDNA deletion
  • PMID 22970697
  • Treatment of hereditary optic neuropathies.
  • Newman NJ.SourceNeuro-ophthalmology Unit, Department of Ophthalmology, Neurology and Neurological Surgery, Emory University School of Medicine, 1365-B Clifton Road NE, Atlanta, GA 30322, USA ophtnjn@emory.edu.
  • Nature reviews. Neurology.Nat Rev Neurol.2012 Sep 4;8(10):545-56. doi: 10.1038/nrneurol.2012.167. Epub 2012 Sep 4.
  • The hereditary optic neuropathies are inherited disorders in which optic nerve dysfunction is a prominent feature in the phenotypic expression of disease. Optic neuropathy may be primarily an isolated finding, such as in Leber hereditary optic neuropathy and dominant optic atrophy, or part of a mult
  • PMID 22945544


  • Leber遺伝性視神経症認定基準
  • 中村 誠,三村 治,若倉 雅登 [他]
  • 日本眼科学会雑誌 119(5), 339-346, 2015-05
  • NAID 40020472925
  • Macular thickness changes in a patient with Leber's hereditary optic neuropathy
  • Mizoguchi Ayako,Hashimoto Yuki,Shinmei Yasuhiro,Nozaki Mayo,Ishijima Kan,Tagawa Yoshiaki,Ishida Susumu
  • BMC ophthalmology 15, 27, 2015-03-18
  • … Background: Leber's hereditary optic neuropathy (LHON) refers to an optic nerve dysfunction due to mutations in the mitochondrial DNA, resulting in visual loss by apoptosis of retinal ganglion cells (RGC). … The macular GCC thickness map may detect the earliest morphological changes in LHON, as well as the temporal area of cpRNFL, before funduscopic examination reveals optic nerve atrophy. …
  • NAID 120005606032
  • Mitochonic Acid 5 (MA-5), a Derivative of the Plant Hormone Indole-3-Acetic Acid, Improves Survival of Fibroblasts from Patients with Mitochondrial Diseases
  • Suzuki Takehiro,Yamaguchi Hiroaki,Kikusato Motoi,Matsuhashi Tetsuro,Matsuo Akihiro,Sato Takeya,Oba Yuki,Watanabe Shun,Minaki Daichi,Saigusa Daisuke,Shimbo Hiroko,Mori Nobuyoshi,Mishima Eikan,Shima Hisato,Akiyama Yasutoshi,Takeuchi Yoichi,Yuri Akinori,Kikuchi Koichi,Toyohara Takafumi,Suzuki Chitose,Kohzuki Masahiro,Anzai Jun-ichi,Mano Nariyasu,Kure Shigeo,Yanagisawa Teruyuki,Tomioka Yoshihisa,Toyomizu Masaaki,Ito Sadayoshi,Osaka Hitoshi,Hayashi Ken-ichiro,Abe Takaaki
  • The Tohoku Journal of Experimental Medicine 236(3), 225-232, 2015
  • … Importantly, MA-5 improved the survival of fibroblasts established from patients with mitochondrial diseases under the stress-induced condition, including Leigh syndrome, MELAS (myopathy encephalopathy lactic acidosis and stroke-like episodes), Leber's hereditary optic neuropathy, and Kearns-Sayre syndrome. …
  • NAID 130005083526


Leber hereditary optic neuropathy (LHON) is an inherited form of vision loss. Although this condition usually begins in a person's teens or twenties, rare cases may appear in early childhood or later in adulthood. For ...
Summary Leber's hereditary optic neuropathy (LHON) is a mitochondrial neurodegenerative disease affecting the optic nerve and often characterized by sudden vision loss in young adult carriers. Prevalence of the disease is not well ...


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  [★] レーベル遺伝性視神経症 = レーバー遺伝性視神経萎縮症 Leber hereditary optic neuropathy




WordNet   license wordnet

「optical properties; "the optics of a telescope"」

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「the branch of physics that studies the physical properties of light」

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  • v.

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「(・・・を)選ぶ《+『for』+『名』》;(・・・するほうを)選ぶ《+『to』 do》」



  • adj.
  • 遺伝性の、遺伝の
heredityheritableinheritinheritableinheritable characterinheritanceinherited

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「世襲の,親譲りの / 遺伝的な,遺伝性の」



  • adj.
  • 視覚性の、視覚の

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  [★] ニューロパチー


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「any pathology of the peripheral nerves」