WordNet

tend to or result in; "This remark lead to further arguments among the guests"
a soft heavy toxic malleable metallic element; bluish white when freshly cut but tarnishes readily to dull grey; "the children were playing with lead soldiers" (同)Pb, atomic number 82
(sports) the score by which a team or individual is winning
the angle between the direction a gun is aimed and the position of a moving target (correcting for the flight time of the missile)
thin strip of metal used to separate lines of type in printing (同)leading
mixture of graphite with clay in different degrees of hardness; the marking substance in a pencil (同)pencil lead
a position of leadership (especially in the phrase `take the lead'
an advantage held by a competitor in a race; "he took the lead at the last turn"
the playing of a card to start a trick in bridge; "the lead was in the dummy"
a news story of major importance (同)lead story
the introductory section of a story; "it was an amusing lead-in to a very serious matter" (同)lead-in, lede
evidence pointing to a possible solution; "the police are following a promising lead"; "the trail led straight to the perpetrator" (同)track, trail
(baseball) the position taken by a base runner preparing to advance to the next base; "he took a long lead off first"
travel in front of; go in advance of others; "The procession was headed by John" (同)head
take somebody somewhere; "We lead him to our chief"; "can you take me to the main entrance?"; "He conducted us to the palace" (同)take, direct, conduct, guide
be ahead of others; be the first; "she topped her class every year" (同)top
cause to undertake a certain action; "Her greed led her to forge the checks"
going or proceeding or going in advance; showing the way; "we rode in the leading car"; "the leading edge of technology"
greatest in importance or degree or significance or achievement; "our greatest statesmen"; "the countrys leading poet"; "a preeminent archeologist" (同)preeminent
indicating the most important performer or role; "the leading man"; "prima ballerina"; "prima donna"; "a star figure skater"; "the starring role"; "a stellar role"; "a stellar performance" (同)prima, star, starring, stellar
treated or mixed with lead; "leaded gasoline"; "leaded zinc"
(of panes of glass) fixed in place by means of thin strips of lead; "leaded windowpanes"
having thin strips of lead between the lines of type
a unit of length of thread or yarn

PrepTutorEJDIC

《方向を表す副詞[句]を伴って》…‘を'『導く』,案内する / 〈道・灯火などが〉…‘に'道筋を示す;(…へ)…‘を'導く《+『名』+『to』(『into』)+『名』》 / …‘の'先頭になる,1番である / …‘の'『率いる』,指揮する / 〈ある人生・生活〉‘を'経験する,生きる,送る / 『先頭に立つ』,(競技・成績などで)リードスル / 〈人が〉『案内する』,先導する / (…に)〈道などが〉『通じている』《+『to』+『名』》 / (…の)結果となる《+『to』+『名』(do『ing』)》 / 〈U〉《the~》『先頭』,首位 / 〈C〉《a~》相手を引き離した点(時間,距離) / 〈C〉模範,手本(example) / 〈C〉(問題解決の)手がかり,ヒント(clue) / 〈C〉(劇・映画などの)主役,主演俳優 / 〈C〉(新聞報道記事などの本文の前におく要約した)前文,前書き,リード / 先頭の,主要な
〈U〉『鉛』(化学記号はは『pb』) / 〈C〉鉛のおもり,測鉛 / 〈C〉《複数形で》(ガラスをはめる)鉛の枠(わく);《英》(屋根をふくのに用いる)鉛板 / 〈U〉〈C〉黒鉛,鉛筆のしん / 〈U〉《集合的に》(鉛の)弾丸 / …‘に'鉛をかぶせる,鉛を詰める,鉛のおもりを付ける
『先導する』,先頭の / 『主要な』,一流の / 指導する / 指導
(ガソリンが)四エチル鉛入りの
草原,牧草地(meadow)

UpToDate Contents

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1. 小児期の鉛中毒：臨床症状および診断 childhood lead poisoning clinical manifestations and diagnosis
2. 小児期の鉛中毒：管理 childhood lead poisoning management
3. 小児期の鉛中毒：曝露と予防 childhood lead poisoning exposure and prevention

English Journal

Cerebrovascular Dysfunction in Preeclamptic Pregnancies.

Hammer ES1, Cipolla MJ.
Current hypertension reports.Curr Hypertens Rep.2015 Aug;17(8):575. doi: 10.1007/s11906-015-0575-8.
Preeclampsia is a hypertensive, multisystem disorder of pregnancy that affects several organ systems, including the maternal brain. Cerebrovascular dysfunction during preeclampsia can lead to cerebral edema, seizures, stroke, and potentially maternal mortality. This review will discuss the effects o
PMID 26126779

Mutations in the mitochondrial cysteinyl-tRNA synthase gene, CARS2, lead to a severe epileptic encephalopathy and complex movement disorder.

Coughlin CR 2nd1, Scharer GH2, Friederich MW1, Yu HC1, Geiger EA1, Creadon-Swindell G1, Collins AE3, Vanlander AV4, Coster RV4, Powell CA5, Swanson MA1, Minczuk M5, Van Hove JL1, Shaikh TH6.
Journal of medical genetics.J Med Genet.2015 Aug;52(8):532-40. doi: 10.1136/jmedgenet-2015-103049. Epub 2015 Mar 18.
BACKGROUND: Mitochondrial disease is often suspected in cases of severe epileptic encephalopathy especially when a complex movement disorder, liver involvement and progressive developmental regression are present. Although mutations in either mitochondrial DNA or POLG are often present, other nuclea
PMID 25787132

Changing phenotypic expression in a patient with a mitochondrial encephalopathy due to 13042G>A de novo mutation-a 5 year follow up.

Schinwelski M1, Kierdaszuk B, Dulski J, Tońska K, Kodroń A, Sitek EJ, Bartnik E, Kamińska A, Kwieciński H, Sławek J.
Metabolic brain disease.Metab Brain Dis.2015 Aug;30(4):1083-5. doi: 10.1007/s11011-014-9645-x. Epub 2014 Dec 31.
Mutations in NADH dehydrogenase (ND) subunits of complex I lead to mitochondrial encephalomyopathies associated with various phenotypes. This report aims to present the patient's clinical symptomatology in the context of a very rare 13042G>A de novo mutation and with an emphasis on changing pheno
PMID 25550170

Japanese Journal

海外旅行を契機に発症した成人発症II型シトルリン血症の1例

山﨑正禎,島田拓弥,濱岡志麻 [他],柴田益成,内藤寛
臨床神経学 54(9), 747-750, 2014
症例は43歳の男性である．弟に痙攣重積で死亡の家族歴あり．3日間の海外旅行から帰った翌日から異常行動，意識障害が出現し，当科に入院した．高アンモニア血症と脳波で前頭部優位の左右差のない徐波の群発をみとめ，肝性脳症と考えた．分枝鎖アミノ酸製剤の輸液で症状は一時改善した．アミノ酸分析で血漿シトルリン高値をみとめ，遺伝子解析により成人発症II型シトルリン血症と確定診断した．食事療法と薬物療法で良好な状態 …
NAID 130004696177

｢児科雑誌｣に発表された仮称所謂脳膜炎(鉛毒性脳症)に関する研究の足跡(9)1927年から内務省令改正(1930年)まで(後編)

堀口俊一,寺本敬子,西尾久英 e 他
労働科学 = The journal of science of labour 89(2), 56-73, 2013
NAID 40019917679

「児科雑誌」に発表された仮称所謂脳膜炎（鉛毒性脳症）に関する研究の足跡（９） 1927年から内務省令改正（1930年）まで（後編）

堀口俊一,寺本敬子,西尾久英,林千代
労働科学 89(2), 56-73, 2013
我が国において，1895（明治28）年に「仮称所謂脳膜炎」と称される乳幼児の疾病が報告されて以来，その原因が母親の用いる白粉中の鉛に因る中毒であることが1923（大正12）年，京都大学小児科教授平井毓太郎によって明らかにされた。以来，小児科学領域において，該疾患に対する研究報告が堰を切ったように発表された。前報において，1927（昭和2）年以降，鉛白使用化粧品に対する規則が明文化された1930（昭 …
NAID 130004709098

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