lamotrigine

出典: meddic

ラモトリギン

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/12/31 07:36:48」(JST)

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2017/08/18 05:54:25」(JST)

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英文文献

  • The antiepileptic drug lamotrigine is a substrate of mouse and human breast cancer resistance protein (ABCG2).
  • Römermann K1, Helmer R2, Löscher W3.
  • Neuropharmacology.Neuropharmacology.2015 Jun;93:7-14. doi: 10.1016/j.neuropharm.2015.01.015. Epub 2015 Jan 31.
  • Resistance to antiepileptic drugs (AEDs) is the major problem in the treatment of epilepsy. One hypothesis to explain AED resistance suggests that seizure-induced overexpression of efflux transporters at the blood-brain barrier (BBB) restricts AEDs to reach their brain targets. Various studies exami
  • PMID 25645391
  • Retention rate of zonisamide in intractable epilepsy.
  • Nakken KO1, Lindstrøm P, Andersen H.
  • Acta neurologica Scandinavica.Acta Neurol Scand.2015 May;131(5):268-74. doi: 10.1111/ane.12379. Epub 2015 Feb 3.
  • OBJECTIVES: To assess the effect and tolerability of zonisamide (ZNS) as adjunctive treatment for difficult-to-treat epilepsy in adult Scandinavian patients.MATERIAL AND METHODS: 151 outpatients (mean age: 42.5 years) from 18 centres in Denmark, Sweden and Norway were recruited to the study. 81.5%
  • PMID 25644477
  • Chemical inhibition of bacterial ribosome biogenesis shows efficacy in a worm infection model.
  • Stokes JM1, Selin C2, Cardona ST3, Brown ED4.
  • Antimicrobial agents and chemotherapy.Antimicrob Agents Chemother.2015 May;59(5):2918-20. doi: 10.1128/AAC.04690-14. Epub 2015 Feb 23.
  • The development of antibacterial compounds that perturb novel processes is an imperative in the challenge presented by widespread antibiotic resistance. While many antibiotics target the ribosome, molecules that inhibit ribosome assembly have yet to be used in this manner. Here we show that a novel
  • PMID 25712357

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