関: lamin type B

WordNet

the 2nd letter of the Roman alphabet (同)b
the blood group whose red cells carry the B antigen (同)type_B, group B

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…‘を'打つ,たたく,なぐる / 打つ,たたく,なぐる
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/01/12 16:51:34」(JST)

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Lamin B2 is a protein that in humans is encoded by the LMNB2 gene. It is the second of two type B nuclear lamins, and it is associated with laminopathies.

Model organisms

*Lmnb2* knockout mouse phenotype
Characteristic	Phenotype
Homozygote viability	Abnormal
Recessive lethal study	Abnormal
Fertility	Normal
Body weight	Normal
Anxiety	Normal
Neurological assessment	Normal
Grip strength	Normal
Hot plate	Normal
Dysmorphology	Normal
Indirect calorimetry	Normal
Glucose tolerance test	Normal
Auditory brainstem response	Normal
DEXA	Normal
Radiography	Normal
Body temperature	Normal
Eye morphology	Normal
Clinical chemistry	Abnormal^[1]
Haematology	Normal
Peripheral blood lymphocytes	Normal
Micronucleus test	Normal
Heart weight	Normal
Brain histopathology	Normal
Salmonella infection	Abnormal^[2]
Citrobacter infection	Normal^[3]
All tests and analysis from^[4]^[5]

Model organisms have been used in the study of Lamin B2 function. A conditional knockout mouse line, called Lmnb2^{tm1a(KOMP)Wtsi}^[6]^[7] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.^[8]^[9]^[10]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.^[4]^[11] Twenty four tests were carried out on mutant mice and four significant abnormalities were observed.^[4] No homozygous mutant embryos were identified during gestation, and therefore none survived until weaning. The remaining tests were carried out on heterozygous mutant adult mice. Male heterozygotes displayed increased circulating creatinine levels and an increased susceptibility to Salmonella infection.^[4]

External links

Lamin B at the US National Library of Medicine Medical Subject Headings (MeSH)

References

^ "Clinical chemistry data for Lmnb2". Wellcome Trust Sanger Institute.
^ "Salmonella infection data for Lmnb2". Wellcome Trust Sanger Institute.
^ "Citrobacter infection data for Lmnb2". Wellcome Trust Sanger Institute.
^ ^a ^b ^c ^d Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x.
^ Mouse Resources Portal, Wellcome Trust Sanger Institute.
^ "International Knockout Mouse Consortium".
^ "Mouse Genome Informatics".
^ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature 474 (7351): 337–342. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
^ Dolgin E (2011). "Mouse library set to be knockout". Nature 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
^ Collins FS, Rossant J, Wurst W (2007). "A Mouse for All Reasons". Cell 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
^ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism.". Genome Biol 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.

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UpToDate Contents

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English Journal

A novel desmin mutation leading to autosomal recessive limb-girdle muscular dystrophy: distinct histopathological outcomes compared with desminopathies.

Cetin N, Balci-Hayta B, Gundesli H, Korkusuz P, Purali N, Talim B, Tan E, Selcen D, Erdem-Ozdamar S, Dincer P.SourceDepartment of Medical Biology, Hacettepe University Faculty of Medicine, Sihhiye Ankara 06100, Turkey; pdincer@hacettepe.edu.tr.
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PMID 23687351

Nuclear structures in Tribolium castaneum oocytes.

Bogolyubov DS, Batalova FM, Kiselyov AM, Stepanova IS.SourceInstitute of Cytology, Russian Academy of Sciences, Tikhoretsky Ave. 4, St. Petersburg, 194064, Russia.
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The first ultrastructural and immunomorphological characteristics of the karyosphere (karyosome) and extrachromosomal nuclear bodies in the red flour beetle, Tribolium castaneum, are presented. The karyosphere forms early in the diplotene stage of meiotic prophase by the gathering of all oocyte chro
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When untethered, something silent inside comes.

Politz JC, Ragoczy T, Groudine M.SourceDivision of Basic Sciences; Fred Hutchinson Cancer Research Center; Seattle, WA USA.
Nucleus (Austin, Tex.).Nucleus.2013 May 15;4(3). [Epub ahead of print]
Heterochromatin usually is sequestered near the periphery and the nucleoli in mammalian nuclei. However, in terminally differentiated retinal rod cells of nocturnal mammals, heterochromatin instead accumulates in the interior, to give a so-called inside-out nuclear architecture. Solovei et al. now r
PMID 23714733

Related Pictures

★リンクテーブル★

リンク元	「カスパーゼ」「ラミンB」
関連記事	「B」

「カスパーゼ」

Lamin B2
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	2LLL
Identifiers
Symbols	LMNB2 ; LAMB2; LMN2
External IDs	OMIM: 150341 HomoloGene: 7818 GeneCards: LMNB2 Gene
Gene ontology
Molecular function	• molecular_function; • structural molecule activity;
Cellular component	• nuclear inner membrane; • lamin filament;
Biological process	• biological_process;
	Sources: Amigo / QuickGO
Orthologs
	v; t; e;

　　[★]

英: caspase
同: ICEファミリープロテアーゼ ICE family protease

ヒトICEプロテアーゼスーパーファミリー

Family	Caspase	Other Name	Recognition	Target (Truncation site)
caspase-1	caspase-1	ICE	WEHD	pro IL-1β (FEAD/G, YVHD/A), procaspase-3, procaspase-4
	caspase-4	ICErel-II, TX, ICH-2
	caspase-5	ICErel-III, TY
caspase-2	caspase-2	ICH-1	DEHD	PARP (DEVD/G)
caspase-2	caspase-9	ICE-LAP6, Mch6	LEHD	PARP, procaspase-3
caspase-3	caspase-3	CPP32, Yama	DEVD	PARP, SREBP (DEPD/S), U1snRNP (DGPD/G), lamin B, D4-GDI (DELD/S), DNA-PK (DEVD/N), DFF (DETD/S, DAVD/T), actin (ELPD/G) ?, PKCδ (DMQD/N) ?]]
	caspase-7	Mch3, ICE-LAP3, CMH-1	DEVD	PARP, procaspase-6
	caspase-6	Mch2	VEHD	lamin A (VEID/N)]]
	caspase-8	FLICE, MACH, Mch5	LETD	procaspase-3, Bid
	caspase-10	Mch4	LEXD
	caspase-11	Ich3

「ラミンB」

　　[★]

英: lamin B、lamin type B

「B」

　　[★]

気管分岐部下緑
補体のalternative pathwayに関わる蛋白質

Mg2+存在下でC3, B, Dが反応してC3bBbとなり、これがC3転換酵素(C3bBb)あるいはC5転換酵素(C3bBb3b)を形成する。これらはP(properdin)と結合して活性化し、それぞれC3、C5を活性化する

[Clinical_chemistry-1] "Clinical chemistry data for Lmnb2". Wellcome Trust Sanger Institute.

[.27.27Salmonella.27.27_infection-2] "Salmonella infection data for Lmnb2". Wellcome Trust Sanger Institute.

[.27.27Citrobacter.27.27_infection-3] "Citrobacter infection data for Lmnb2". Wellcome Trust Sanger Institute.

[mgp_reference-4] Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x.

[5] Mouse Resources Portal, Wellcome Trust Sanger Institute.

[allele_ref-6] "International Knockout Mouse Consortium".

[mgi_allele_ref-7] "Mouse Genome Informatics".

[pmid21677750-8] Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature 474 (7351): 337–342. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.

[mouse_library-9] Dolgin E (2011). "Mouse library set to be knockout". Nature 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.

[mouse_for_all_reasons-10] Collins FS, Rossant J, Wurst W (2007). "A Mouse for All Reasons". Cell 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247.

[pmid21722353-11] van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism.". Genome Biol 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.

匿名

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案内

案内

lamin B