keratoderma

角皮症、角化症、角化性皮膚疾患、角皮、皮膚角化症

関: cuticle、cuticular、keratoses、keratosis

　

WordNet

any skin disorder consisting of a growth that appears horny (同)keratodermia
the dead skin at the base of a fingernail or toenail
a skin condition marked by an overgrowth of layers of horny skin
of or relating to a cuticle or cuticula (同)epidermal, epidermic, dermal

PrepTutorEJDIC

(動物の体表をおおう)表皮;(つめのつけ根の)あま皮

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/02/09 17:47:03」(JST)

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Keratoderma
Classification and external resources
ICD-10	L85.1, L86, Q82.8
ICD-9	701.1, 757.39

Keratoderma is a hornlike skin condition.^[1]

Contents

1 Classification
- 1.1 Congenital
- 1.2 Acquired
2 See also
3 References

Classification

The keratodermas are classified into the following subgroups^[2]^:506:

Congenital

Simple keratodermas
- Diffuse palmoplantar keratodermas
  - Diffuse epidermolytic palmoplantar keratoderma
  - Diffuse nonepidermolytic palmoplantar keratoderma
  - mal de Meleda
- Focal palmoplantar keratoderma
  - Striate palmoplantar keratoderma
- Punctate palmoplantar keratoderma
  - Keratosis punctata palmaris et plantaris
  - Spiny keratoderma
  - Focal acral hyperkeratosis
Complex keratodermas
- Diffuse palmoplantar keratoderma
  - Erythrokeratodermia variabilis
  - Palmoplantar keratoderma of Sybert
  - Olmsted syndrome
  - Naegeli-Franceschetti-Jadassohn syndrome
- Focal palmoplantar keratoderma
  - Papillon-Lefèvre syndrome
  - Pachyonychia congenita type I
  - Pachyonychia congenita type II
  - Focal palmoplantar keratoderma with oral mucosal hyperkeratosis
  - Camisa disease
- Ectodermal dysplasias
  - Clouston's hidrotic ectodermal dysplasia
  - Acrokeratotic poikiloderma
  - Dermatopathic pigmentosa reticularis
- Syndromic keratodermas
  - Vohwinkel syndrome
  - Palmoplantar keratoderma associated with esophageal cancer
  - Palmoplantar keratoderma and spastic paraplegia
  - Naxos disease
  - Striate palmoplantar keratoderma, woolly hair, and left ventricular dilated cardiomyopathy
  - Keratitis-ichthyosis-deafness syndrome
  - Corneodermatosseous syndrome
  - Huriez syndrome
  - Oculocutaneous tyrosinemia
  - Cardiofaciocutaneous syndrome
  - Schöpf-Schulz-Passarge syndrome

Acquired

Acquired keratodermas
- AIDS-associated keratoderma
- Arsenical keratoses
- Calluses
- Climacteric keratoderma
- Clavi (Corns)
- Eczema
- Human papillomavirus
- Keratoderma blenorrhagicum
- Lichen planus
- Norwegian scabies
- Paraneoplastic keratoderma
- Psoriasis
- Reiter's syndrome
- Secondary syphilis
- Tinea pedis
- Sézary syndrome
- Tuberculosis verrucosa cutis
- Drug-induced keratoderma^[3]

See also

Palmoplantar keratoderma
Skin lesion
List of cutaneous conditions
List of conditions caused by problems with junctional proteins

References

^ WordNet Search - 3.0
^ Freedberg, et al. (2003). Fitzpatrick's Dermatology in General Medicine. (6th ed.). McGraw-Hill. ISBN 0-07-138076-0.
^ Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. pp. 778. ISBN 1-4160-2999-0.

Cutaneous keratosis, ulcer, atrophy, and necrobiosis (L82–L94, 700–701.5)

Epidermal thickening

keratoderma: Keratoderma climactericum
Paraneoplastic keratoderma
- Acrokeratosis paraneoplastica of Bazex
Aquagenic keratoderma
Drug-induced keratoderma
Paraneoplastic keratoderma
psoriasis
- Keratoderma blennorrhagica

keratosis: Seborrheic keratosis
- Clonal seborrheic keratosis
- Common seborrheic keratosis
- Irritated seborrheic keratosis
- Seborrheic keratosis with squamous atypia
- Reticulated seborrheic keratosis
- Dermatosis papulosa nigra
Keratosis punctata of the palmar creases

other hyperkeratosis: Acanthosis nigricans
- Confluent and reticulated papillomatosis
Callus
Ichthyosis acquisita
Arsenical keratosis
Chronic scar keratosis
Hyperkeratosis lenticularis perstans
Hydrocarbon keratosis
Hyperkeratosis of the nipple and areola
Inverted follicular keratosis
Lichenoid keratosis
Multiple minute digitate hyperkeratosis
PUVA keratosis
Reactional keratosis
Stucco keratosis
Thermal keratosis
Viral keratosis
Warty dyskeratoma
Waxy keratosis of childhood

other hypertrophy: Keloid
Hypertrophic scar
Cutis verticis gyrata

Necrobiosis/granuloma

Necrobiotic/palisading	Granuloma annulare Perforating Generalized Subcutaneous Granuloma annulare in HIV disease Localized granuloma annulare Patch-type granuloma annulare Necrobiosis lipoidica Annular elastolytic giant cell granuloma Granuloma multiforme Necrobiotic xanthogranuloma Palisaded neutrophilic and granulomatous dermatitis Rheumatoid nodulosis Interstitial granulomatous dermatitis/Interstitial granulomatous drug reaction

Foreign body granuloma	Beryllium granuloma Mercury granuloma Silica granuloma Silicone granuloma Zirconium granuloma Soot tattoo Tattoo Carbon stain

Other/ungrouped	eosinophilic dermatosis Granuloma faciale

Dermis/
localized CTD

Cutaneous lupus erythematosus	chronic: Discoid Panniculitis subacute: Neonatal ungrouped: Chilblain Lupus erythematosus–lichen planus overlap syndrome Tumid Verrucous Rowell's syndrome

Scleroderma/ Morphea	Localized scleroderma Localized morphea Morphea–lichen sclerosus et atrophicus overlap Generalized morphea Atrophoderma of Pasini and Pierini Pansclerotic morphea Morphea profunda Linear scleroderma

Atrophic/ atrophoderma	Lichen sclerosus Anetoderma Schweninger–Buzzi anetoderma Jadassohn–Pellizzari anetoderma Atrophoderma of Pasini and Pierini Acrodermatitis chronica atrophicans Semicircular lipoatrophy Follicular atrophoderma Linear atrophoderma of Moulin

Perforating	Kyrle disease Reactive perforating collagenosis Elastosis perforans serpiginosa Perforating folliculitis Acquired perforating dermatosis

Skin ulcer	Pyoderma gangrenosum

Other	Calcinosis cutis Sclerodactyly Poikiloderma vasculare atrophicans Ainhum/Pseudo-ainhum

M: INT, SF, LCT

anat/phys/devp

noco (i/b/d/q/u/r/p/m/k/v/f)/cong/tumr (n/e/d), sysi/epon

proc, drug (D2/3/4/5/8/11)

Congenital malformations and deformations of integument / skin disease (Q80–Q82, 757.0–757.3)

Genodermatosis

Congenital ichthyosis/
erythrokeratodermia

AD	Ichthyosis vulgaris

AR	Congenital ichthyosiform erythroderma: Epidermolytic hyperkeratosis Lamellar ichthyosis Harlequin type ichthyosis Netherton syndrome Zunich–Kaye syndrome Sjögren–Larsson syndrome

XR	X-linked ichthyosis

Ungrouped	Ichthyosis bullosa of Siemens Ichthyosis follicularis Ichthyosis prematurity syndrome Ichthyosis–sclerosing cholangitis syndrome Nonbullous congenital ichthyosiform erythroderma Ichthyosis linearis circumflexa Ichthyosis hystrix

EB
and related

EBS
- EBS-K
- EBS-WC
- EBS-DM
- EBS-OG
- EBS-MD
- EBS-MP

JEB
- JEB-H
- Mitis
- Generalized atrophic
- JEB-PA

DEB
- DDEB
- RDEB

related: Costello syndrome
Kindler syndrome
Laryngoonychocutaneous syndrome
Skin fragility syndrome

Ectodermal dysplasia

Naegeli syndrome/Dermatopathia pigmentosa reticularis
Hay–Wells syndrome
Hypohidrotic ectodermal dysplasia
Focal dermal hypoplasia
Ellis–van Creveld syndrome
Rapp–Hodgkin syndrome/Hay–Wells syndrome

Elastic/Connective

Ehlers–Danlos syndrome
Cutis laxa (Gerodermia osteodysplastica)
Popliteal pterygium syndrome
Pseudoxanthoma elasticum
Van Der Woude syndrome

Hyperkeratosis/
keratinopathy

PPK	diffuse: Diffuse epidermolytic palmoplantar keratoderma Diffuse nonepidermolytic palmoplantar keratoderma Palmoplantar keratoderma of Sybert Mal de Meleda syndromic connexin Bart–Pumphrey syndrome Clouston's hidrotic ectodermal dysplasia Vohwinkel syndrome Corneodermatoosseous syndrome plakoglobin Naxos syndrome Scleroatrophic syndrome of Huriez Olmsted syndrome Cathepsin C Papillon–Lefèvre syndrome Haim–Munk syndrome Camisa disease focal: Focal palmoplantar keratoderma with oral mucosal hyperkeratosis Focal palmoplantar and gingival keratosis Howel–Evans syndrome Pachyonychia congenita Pachyonychia congenita type I Pachyonychia congenita type II Striate palmoplantar keratoderma Tyrosinemia type II punctate: Acrokeratoelastoidosis of Costa Focal acral hyperkeratosis Keratosis punctata palmaris et plantaris Keratosis punctata of the palmar creases Schöpf–Schulz–Passarge syndrome Porokeratosis plantaris discreta Spiny keratoderma ungrouped: Palmoplantar keratoderma and spastic paraplegia desmoplakin Carvajal syndrome connexin Erythrokeratodermia variabilis HID/KID

Other	Meleda disease Keratosis pilaris ATP2A2 Darier's disease Dyskeratosis congenita Lelis syndrome Dyskeratosis congenita Keratolytic winter erythema Keratosis follicularis spinulosa decalvans Keratosis linearis with ichthyosis congenital and sclerosing keratoderma syndrome Keratosis pilaris atrophicans faciei Keratosis pilaris

Other

cadherin
- EEM syndrome
immune system
- Hereditary lymphedema
- Mastocytosis/Urticaria pigmentosa
Hailey–Hailey

see also Template:Congenital malformations and deformations of skin appendages, Template:Phakomatoses, Template:Pigmentation disorders, Template:DNA replication and repair-deficiency disorder

Developmental
anomalies

Midline	Dermoid cyst Encephalocele Nasal glioma PHACE association Sinus pericranii

Nevus	Capillary hemangioma Port-wine stain Nevus flammeus nuchae

Other/ungrouped	Aplasia cutis congenita Amniotic band syndrome Branchial cyst Cavernous venous malformation Accessory nail of the fifth toe Bronchogenic cyst Congenital cartilaginous rest of the neck Congenital hypertrophy of the lateral fold of the hallux Congenital lip pit Congenital malformations of the dermatoglyphs Congenital preauricular fistula Congenital smooth muscle hamartoma Cystic lymphatic malformation Median raphe cyst Melanotic neuroectodermal tumor of infancy Mongolian spot Nasolacrimal duct cyst Omphalomesenteric duct cyst Poland anomaly Rapidly involuting congenital hemangioma Rosenthal–Kloepfer syndrome Skin dimple Superficial lymphatic malformation Thyroglossal duct cyst Verrucous vascular malformation Birthmark

M: INT, SF, LCT

anat/phys/devp

noco (i/b/d/q/u/r/p/m/k/v/f)/cong/tumr (n/e/d), sysi/epon

proc, drug (D2/3/4/5/8/11)

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UpToDate Contents

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1. 遺伝性皮膚症 the genodermatoses
2. 内臓悪性腫瘍の皮膚症状 cutaneous manifestations of internal malignancy
3. Sézary症候群の臨床症状、病理学的特徴、および診断 clinical presentation pathologic features and diagnosis of sezary syndrome
4. 反応性関節炎（旧ライター症候群） reactive arthritis formerly reiter syndrome
5. 好中球性皮膚症 neutrophilic dermatoses

English Journal

Two novel de novo mutations of KRT6A and KRT16 genes in two Chinese pachyonychia congenita pedigrees with fissured tongue or diffuse plantar keratoderma.

Du ZF, Xu CM, Zhao Y, Liu WT, Chen XL, Chen CY, Fang H, Ke HP, Zhang XN.SourceDepartment of Biochemistry and Genetics, Zhejiang University School of Medicine, 866 Yuhangtang Road, Hangzhou 310058, China.
European journal of dermatology : EJD.Eur J Dermatol.2012 Jun 5. [Epub ahead of print]
Mutations in the KRT6A or KRT16 gene cause pachyonychia congenita type 1 (PC-1), while mutations in KRT16 or KRT6C underlie focal palmoplantar keratoderma (FPPK). A new classification system of PC has been adopted based on the mutated gene. PC rarely presents the symptoms of diffuse plantar keratode
PMID 22668561

An appraisal of oral retinoids in the treatment of pachyonychia congenita.

Gruber R, Edlinger M, Kaspar RL, Hansen CD, Leachman S, Milstone LM, Smith FJ, Sidoroff A, Fritsch PO, Schmuth M.SourceDepartment of Dermatology, Innsbruck Medical University, Innsbruck, Austria.
Journal of the American Academy of Dermatology.J Am Acad Dermatol.2012 Jun;66(6):e193-9. Epub 2011 May 24.
BACKGROUND: Pachyonychia congenita (PC), a rare autosomal-dominant keratin disorder caused by mutations in keratin genes KRT6A/B, KRT16, or KRT17, is characterized by painful plantar keratoderma and hypertrophic nail dystrophy. Available studies assessing oral retinoid treatment for PC are limited t
PMID 21601946

Japanese Journal

Striate palmoplantar keratoderma

KAWAI Kazuhiro,FUKUSHIGE Tomoko,SAKANOUE Masanao,KANEKURA Takuro
Journal of dermatology 37(9), 854-856, 2010-09-01
NAID 10027067427

踵部の過角化病変上に生じた無色素性悪性黒色腫の1例 : 掌蹠角化症に生じた悪性黒色腫の検討

山田英枝,相馬孝光,嶋田菜々子,吉田寿斗志,伊東秀記,幸田公人,松尾光馬,石地尚興,中川秀己
日本皮膚科学会雑誌 120(2), 227-232, 2010-02-20
NAID 10028279046

Clinical, histological and genetic investigation of Buschke-Fischer-Brauer's disease in Tunisian families

BCHETNIA Mbarka,CHARFEDDINE Cherine,KASSAR Selma,HANCHI Imen,TOUNSI-GUETTITI Haifa,REBAI Ahmed,DHAHRI-BEN OSMAN Amel,KUBISCH Christian,ABDELHAK Sonia,BOUBAKER Samir,MOKNI Mourad
Journal of dermatological science 54(1), 54-56, 2009-04-01
NAID 10025333237

Related Links

Keratoderma - Wikipedia, the free encyclopedia

Keratoderma is a hornlike skin condition. ... The keratodermas are classified into the following subgroups :506: ... keratoderma: Keratoderma climactericum • Paraneoplastic keratoderma (Acrokeratosis paraneoplastica of Bazex ) • Aquagenic ...

Keratoderma blennorrhagica - Wikipedia, the free encyclopedia

Keratoderma blennorrhagica is commonly seen as an additional feature of reactive arthritis (Reiter's syndrome) in almost 15% of male patients. The appearance is usually of a vesico-pustular waxy lesion with a yellow brown colour.

Related Pictures

★リンクテーブル★

リンク元	「角皮」「cuticular」「角皮症」「皮膚角化症」「角化性皮膚疾患」
拡張検索	「palmoplantar keratoderma」「keratoderma blennorrhagicum」

「角皮」

英: cuticle、keratoderma、cuticular
関: 角質、クチクラ、角化症、角化性皮膚疾患、角皮症、皮膚角化症

「cuticular」

adj.

角質の、角皮の、クチクラの

関: corneum、cuticle、horny、keratoderma

　

「角皮症」

英: keratoderma
関: 角皮、角化症、角化性皮膚疾患、皮膚角化症

「皮膚角化症」

英: keratoderma
関: 角皮、角化症、角化性皮膚疾患、角皮症

「角化性皮膚疾患」

英: keratoderma
関: 角皮、角化症、角皮症、皮膚角化症

「palmoplantar keratoderma」

掌蹠角化症、掌蹠角皮症、手掌角化症、手掌角皮症

関: palmoplantar keratosis

「keratoderma blennorrhagicum」

膿漏性角皮症、膿漏性角化症

関: keratoderma blenorrhagica、keratosis

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