kanamycin kinase

カナマイシンキナーゼ

WordNet

1. an enzyme that catalyzes the conversion of a proenzyme to an active enzyme
2. antibiotic (trade name Kantrex) used to treat severe infections (同)Kantrex
3. the basic unit of money in Papua New Guinea

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/07/13 00:55:08」(JST)

wiki en

[Wiki en表示]

kanamycin kinase
Identifiers
EC number	2.7.1.95
CAS number	62213-36-9
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a kanamycin kinase also known as aminoglycoside-3'-phosphotransferase is an enzyme that catalyzes the chemical reaction

ATP + kanamycin ADP + kanamycin 3'-phosphate

Thus, the two substrates of this enzyme are ATP and kanamycin, whereas its two products are ADP and kanamycin 3'-phosphate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:kanamycin 3'-O-phosphotransferase. This enzyme is also called neomycin-kanamycin phosphotransferase.

References

Further reading

• Doi O, Ogura M, Tanaka N, Umezawa H (Sep 1968). "Inactivation of kanamycin, neomycin, and streptomycin by enzymes obtained in cells of Pseudomonas aeruginoa". Applied Microbiology 16 (9): 1276–81. PMC 547640. PMID 4970990. 
• Dolin MI (Mar 1957). "The Streptococcus faecalis oxidases for reduced diphosphopyridine nucleotide. III. Isolation and properties of a flavin peroxidase for reduced diphosphopyridine nucleotide". The Journal of Biological Chemistry 225 (1): 557–73. PMID 13416259. 

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

• 1. 腸球菌における抗菌薬耐性の機構 mechanisms of antibiotic resistance in enterococci
• 2. 成人の薬剤耐性結核の治療 treatment of drug resistant pulmonary tuberculosis in adults
• 3. Epidemiology of extensively drug-resistant tuberculosis
• 4. Diagnosis of pulmonary tuberculosis in adults
• 5. 抗結核薬：概要 antituberculous drugs an overview

English Journal

• Genetic transformation of the white-rot fungus Dichomitus squalens using a new commercial protoplasting cocktail.

• Daly P1, Slaghek GG1, Casado López S1, Wiebenga A1, Hilden KS2, de Vries RP3, Mäkelä MR4.
• Journal of microbiological methods.J Microbiol Methods.2017 Dec;143:38-43. doi: 10.1016/j.mimet.2017.10.001. Epub 2017 Oct 4.
• PMID 28987554

• Conjugal transfer of aac(6')Ie-aph(2″)Ia gene from native species and mechanism of regulation and cross resistance in Enterococcus faecalis MCC3063 by real time-PCR.

• Jaimee G1, Halami PM2.
• Microbial pathogenesis.Microb Pathog.2017 Sep;110:546-553. doi: 10.1016/j.micpath.2017.07.049. Epub 2017 Jul 31.
• PMID 28774859

• Fludarabine resistance mediated by aminoglycoside-3'-phosphotransferase-IIa and the structurally related eukaryotic cAMP-dependent protein kinase.

• Sánchez-Carrera D1, Bravo-Navas S1, Cabezón E2, Arechaga I2, Cabezas M2, Yáñez L1, Pipaón C3.
• FASEB journal : official publication of the Federation of American Societies for Experimental Biology.FASEB J.2017 Jul;31(7):3007-3017. doi: 10.1096/fj.201601245R. Epub 2017 Apr 3.
• PMID 28373209

Japanese Journal

• <i>In vitro</i> evaluation of candidate <i>Bacillus</i> spp. for animal feed

• The Journal of General and Applied Microbiology, 2017
• NAID 130005464991

• Effect of sclerin on production of the aminoglycoside antibiotics accompanied by salvage function in Streptomyces.

• Agricultural and Biological Chemistry 39(8), 1593-1598, 1975
• NAID 130003525054

Related Pictures

---

★リンクテーブル★

関連記事

「kinase」

「kinase」

　　[★] キナーゼ カイネース リン酸化酵素 phosphoenzyme phosphotransferase