kallidin

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/09/24 20:07:08」(JST)

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Kallidin

Names
IUPAC name L-lysyl-L-arginyl-L-prolyl-L-prolyl-glycyl-L-phenylalanyl-L-seryl-L-prolyl-L-phenylalanyl-L-arginine
Identifiers
CAS Number	342-10-9 Y
3D model (JSmol)	Interactive image
ChemSpider	4470640 Y
ECHA InfoCard	100.005.853
IUPHAR/BPS	650
MeSH	Kallidin
PubChem CID	5311111
InChI InChI=1S/C56H85N17O12/c57-24-8-7-18-36(58)46(76)67-37(19-9-25-63-55(59)60)51(81)73-29-13-23-44(73)53(83)72-28-11-21-42(72)49(79)65-32-45(75)66-39(30-34-14-3-1-4-15-34)47(77)70-41(33-74)52(82)71-27-12-22-43(71)50(80)69-40(31-35-16-5-2-6-17-35)48(78)68-38(54(84)85)20-10-26-64-56(61)62/h1-6,14-17,36-44,74H,7-13,18-33,57-58H2,(H,65,79)(H,66,75)(H,67,76)(H,68,78)(H,69,80)(H,70,77)(H,84,85)(H4,59,60,63)(H4,61,62,64)/t36-,37-,38-,39-,40-,41-,42-,43-,44-/m0/s1 Y Key: FYSKZKQBTVLYEQ-FSLKYBNLSA-N Y InChI=1/C56H85N17O12/c57-24-8-7-18-36(58)46(76)67-37(19-9-25-63-55(59)60)51(81)73-29-13-23-44(73)53(83)72-28-11-21-42(72)49(79)65-32-45(75)66-39(30-34-14-3-1-4-15-34)47(77)70-41(33-74)52(82)71-27-12-22-43(71)50(80)69-40(31-35-16-5-2-6-17-35)48(78)68-38(54(84)85)20-10-26-64-56(61)62/h1-6,14-17,36-44,74H,7-13,18-33,57-58H2,(H,65,79)(H,66,75)(H,67,76)(H,68,78)(H,69,80)(H,70,77)(H,84,85)(H4,59,60,63)(H4,61,62,64)/t36-,37-,38-,39-,40-,41-,42-,43-,44-/m0/s1 Key: FYSKZKQBTVLYEQ-FSLKYBNLBR
SMILES O=C(N[C@H](C(=O)N[C@H](C(=O)O)CCC/N=C(\N)N)Cc1ccccc1)[C@H]5N(C(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@H]3N(C(=O)[C@H]2N(C(=O)[C@@H](NC(=O)[C@@H](N)CCCCN)CCC/N=C(\N)N)CCC2)CCC3)Cc4ccccc4)CO)CCC5
Properties
Chemical formula	C56H85N17O12
Molar mass	1188.38 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Y verify (what is YN ?)
Infobox references

Kallidin is a bioactive kinin formed in response to injury from kininogen precursors through the action of kallikreins.

Kallidin is a decapeptide whose sequence is H-Lys-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH. It can be converted to bradykinin by the aminopeptidase enzyme.

It can be a substrate for carboxypeptidase M and N.

Kallidin is identical to bradykinin with an additional lysine residue added at the N-terminal end and signals through the bradykinin receptor.

English Journal

• Involvement of Extracellular Signal-Regulated Kinase 5 in Kinin B1 Receptor Upregulation in Isolated Human Umbilical Veins.

• Kilstein Y1, Nowak W1, Errasti AE1, Feás AA1, Armesto AR1, Pelorosso FG1, Rothlin RP2.
• The Journal of pharmacology and experimental therapeutics.J Pharmacol Exp Ther.2016 Apr;357(1):114-24. doi: 10.1124/jpet.115.230169. Epub 2016 Jan 14.
• The upregulated kinin B1 receptors exert a pivotal role in modulating inflammatory processes. In isolated human umbilical veins (HUVs), kinin B1 receptor is upregulated as a function of in vitro incubation time and proinflammatory stimuli. The aim of this study was to evaluate, using functional and
• PMID 26769916

• Pre- and post-junctional bradykinin B2 receptors regulate smooth muscle tension to the pig intravesical ureter.

• Ribeiro AS1, Fernandes VS1, Martínez MP2, López-Oliva ME1, Barahona MV3, Recio P1, Martínez AC1, Blaha I4, Orensanz LM5, Bustamante S6, García-Sacristán A1, Prieto D1, Hernández M1.
• Neurourology and urodynamics.Neurourol Urodyn.2016 Jan;35(1):115-21. doi: 10.1002/nau.22685. Epub 2014 Oct 18.
• AIMS: Neuronal and non-neuronal bradykinin (BK) receptors regulate the contractility of the bladder urine outflow region. The current study investigates the role of BK receptors in the regulation of the smooth muscle contractility of the pig intravesical ureter.METHODS: Western blot and immunohistoc
• PMID 25327836

• Imaging Bradykinin B1 Receptor with 68Ga-Labeled [des-Arg10]Kallidin Derivatives: Effect of the Linker on Biodistribution and Tumor Uptake.

• Amouroux G1, Pan J1, Jenni S1, Zhang C1, Zhang Z1, Hundal-Jabal N1, Colpo N1, Liu Z2, Bénard F1,3, Lin KS1,3.
• Molecular pharmaceutics.Mol Pharm.2015 Aug 3;12(8):2879-88. doi: 10.1021/acs.molpharmaceut.5b00070. Epub 2015 Jul 2.
• Bradykinin B1 receptor (B1R) that is overexpressed in cancers but minimally expressed in normal healthy tissues represents an attractive biomarker for the development of cancer imaging agents. The goal of this study was to evaluate the effect of different linkers on the pharmacokinetics and tumor up
• PMID 26101793

Japanese Journal

• Moment Equations for Chromatography Using Superficially Porous Spherical Particles

• Analytical Sciences 27(10), 1007, 2011
• NAID 130004827050

• Involvement of kinins and tachykinins in the development of nasal hyperresponsiveness in a guinea pig pollinosis model

• Inflammation and Regeneration 30(6), 524-530, 2010
• NAID 130004482272

• Na^+/Ca^<2+> exchanger activity modulates connective tissue growth factor mRNA expression in transforming growth factor β1- and Des-Arg^<10>-kallidin-stimulated myofibroblasts

• J Biol Chem 280, 14378-14384, 2005
• NAID 30016366531

Related Links

• Kallidin | definition of kallidin by Medical dictionary

kallidin [kal´ĭ-din] lysyl-bradykinin, a kinin produced by the action of tissue and glandular kallikreins on low-molecular-weight kininogen and having physiologic effects similar to those of bradykinin. Formerly, the term was applied to ...

• kallidinの意味 - goo辞書 英和和英

kallidinとは。意味や和訳。[名詞] 〔生化学〕 カリジン：血漿けっしょう中のキニノーゲに kallikrein を作用させて得られるペプチドの一種.[語源]1950.＜ドイツ語=kalli(krein) KALLIKREIN+D(ekapeptid)デカペプチド+-in -IN2 - 80万項目以上 ...

Related Pictures

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★リンクテーブル★

リンク元	「カリジン」
拡張検索	「kallidinogenase」

「カリジン」

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英

関

英

kallidin

同

キニン10 kinin 10

「kallidinogenase」

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カリジノゲナーゼ

関

kalliginogenase、kallikrein、kininogenase