juxtaglomerular cell

傍糸球体装置、傍糸球体細胞

WordNet

1. small room in which a monk or nun lives (同)cubicle
2. a device that delivers an electric current as the result of a chemical reaction (同)electric cell
3. a room where a prisoner is kept (同)jail cell, prison cell
4. (biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
5. any small compartment; "the cells of a honeycomb"
6. a small unit serving as part of or as the nucleus of a larger political movement (同)cadre

PrepTutorEJDIC

1. (刑務所の)『独房』;(修道院の)小さい独居室 / (ミツバチの)みつ房,巣穴 / 小さい部屋 / 『細胞』 / 電池 / 花粉室 / (共産党などの)細胞

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/11/23 16:28:33」(JST)

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Not to be confused with granule cell.

Juxtaglomerular cell
Microscopic image of juxtaglomerular cells
Drawing of renal corpuscle (juxtaglomerular cells are labeled as number 8. Messenger cells in green are marked with 6.
Anatomical terminology

The juxtaglomerular cells (JG cells, or granular cells) are cells in the kidney that synthesize, store, and secrete the enzyme renin. They are specialized smooth muscle cells mainly in the walls of the afferent arterioles, and some in the efferent arterioles, that deliver blood to the glomerulus. In synthesizing renin, they play a critical role in the renin-angiotensin system and thus in autoregulation of the kidney.

Juxtaglomerular cells secrete renin in response to a drop in pressure detected by stretch receptors in the vascular walls, or when stimulated by macula densa cells. Macula densa cells are located in the distal convoluted tubule, and stimulate juxtaglomerular cells to release renin when they detect a drop in sodium concentration in tubular fluid. Together, juxtaglomerular cells and macula densa cells comprise the juxtaglomerular complex.

In appropriately stained tissue sections, juxtaglomerular cells are distinguished by their granulated cytoplasm.

Similar to cardiac tissue, juxtaglomerular cells harbor β1 adrenergic receptors. When stimulated by epinephrine or norepinephrine, these receptors induce the secretion of renin. These cells also respond directly to a decrease in systemic blood pressure which is manifested as a lower renal perfusion pressure.

See also

• Juxtaglomerular cell tumor
• Juxtaglomerular apparatus

External links

• Histology image: 16010loa – Histology Learning System at Boston University

UpToDate Contents

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English Journal

• [Renal denervation for the treatment of resistant hypertension: definition, patient selection and description of the procedure. 2012 Position paper of the Italian Society of Hypertension].

• Volpe M, Agabiti-Rosei E, Ambrosioni E, Cottone S, Cuspidi C, Borghi C, De Luca N, Fallo F, Ferri C, Mancia G, Morganti A, Muiesan ML, Sarzani R, Sechi L, Tocci G, Virdis A.AbstractHypertension is responsible for a relevant burden of cardiovascular morbidity and mortality worldwide. Although several appropriate and integrated pharmacological strategies are available, blood pressure control still remains largely unsatisfactory. Failure to achieve effective blood pressure control in treated hypertensive patients may have a substantial impact on overall cardiovascular risk, since it significantly increases the risk of both macrovascular and microvascular complications. Hypertension is arbitrarily defined as "resistant" or "refractory" when recommended blood pressure goals (clinic blood pressure <140/90 mmHg, or <130/80 mmHg in patients with type 2 diabetes mellitus) are not achieved, despite changes in lifestyle and treatment with adequate doses of at least three antihypertensive drugs from different classes, including a diuretic. A new non-pharmacological option for the treatment of patients with resistant hypertension has recently become available. Renal sympathetic denervation is a minimally invasive procedure performed via femoral access that uses radiofrequency catheter ablation to disable renal sympathetic afferent and efferent nerves. It results in isolation of renal parenchymal and juxtaglomerular cells from the abnormal enhancement of renal adrenergic nerve activity. The present position paper of the Italian Society of Hypertension provides a diagnostic and therapeutic approach to the early identification and effective clinical management of patients with resistant hypertension, who may be candidates for renal denervation. These indications may have important implications not only from a clinical viewpoint but also from an economic perspective. The accurate identification of patients with resistant hypertension and the appropriate selection of patients eligible for this procedure may help improve blood pressure control and reduce the risk of cardiovascular and cerebrovascular complications in these patients.
• Giornale italiano di cardiologia (2006).G Ital Cardiol (Rome).2012 Dec;13(12):846-52. doi: 10.1714/1188.13169.
• Hypertension is responsible for a relevant burden of cardiovascular morbidity and mortality worldwide. Although several appropriate and integrated pharmacological strategies are available, blood pressure control still remains largely unsatisfactory. Failure to achieve effective blood pressure contro
• PMID 23196688

• Connexin 40 mediates tubuloglomerular feedback paracrine signaling by coupling tubular and vascular cells in the renal juxtaglomerular apparatus.

• Arendshorst WJ.SourceDept. of Cell Biology and Physiology, #7545, Univ. of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7545(e-mail: arends@med.unc.edu.
• American journal of physiology. Renal physiology.Am J Physiol Renal Physiol.2012 Nov;303(10):F1409-11. doi: 10.1152/ajprenal.00494.2012. Epub 2012 Sep 5.
• PMID 22952283

Japanese Journal

• 腹腔鏡下腎部分切除術を施行した傍糸球体細胞腫（レニノーマ）の1例

• 日本泌尿器科學會雑誌 105(4), 202-206, 2014
• NAID 130005104860

• A Rare Case among Hypertensive Patients: How Do We Handle Reninomas?

• Internal Medicine 52(17), 1853-1853, 2013
• NAID 130003365800

• Juxtaglomerular Cell Tumor that was Preoperatively Diagnosed Using Selective Renal Venous Sampling

• Internal Medicine 52(17), 1937-1942, 2013
• NAID 130003365775

Related Links

• Juxtaglomerular cell | Define Juxtaglomerular cell at ...

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• Nonfunctioning Juxtaglomerular Cell Tumor

The juxtaglomerular cell tumor (JGCT) is a rare renal tumor characterized by excessive renin secretion causing intractable hypertension and hypokalemia. However, asymptomatic nonfunctioning JGCT is extremely rare.

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リンク元	「傍糸球体細胞」
拡張検索	「juxtaglomerular cells」
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「傍糸球体細胞」

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英

juxtaglomerular cell (SP)

同

JG細胞 JG cell、輸入細動脈顆粒細胞、糸球体傍細胞、糸球体近接細胞、類上皮細胞

関

傍糸球体装置、糸球体

• 輸入細動脈の平滑筋細胞が上皮様に変化した細胞 (SP.611)
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「juxtaglomerular cells」

　　[★] 傍糸球体装置、傍糸球体細胞

「cell」

　　[★] 細胞