関: isothipendyl hydrochloride

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/08/16 23:26:42」(JST)

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Isothipendyl is a 1st generation H₁ antagonist (antihistamine) and anticholinergic used as an antipruritic. It is nowadays scarcely used in the 1st line relief of allergies due to the anticholinergic side effect of somnolence but does have some limited use through topical application in the relief of insect bites and related itching (pruritus).

References[edit source | edit]

English Journal

Contact photoallergy to isothipendyl chlorhydrate.

Bibas N, Sartor V, Bulai Livideanu C, Bagheri H, Nougué J, Giordano-Labadie F, Maza A, Paul C, Chouini-Lalanne N, Marguery MC.SourcePaul Sabatier University and Department of Dermatology, Larrey Hospital, Université Toulouse III Paul Sabatier, Toulouse, France.
Dermatology (Basel, Switzerland).Dermatology.2012;224(4):289-91. doi: 10.1159/000338024. Epub 2012 Jun 1.
Isothipendyl chlorhydrate is an azaphenothiazine, an active ingredient of an antipruriginous gel, Apaisyl gel® (Merck Médication Familiale, Dijon, France). Although Apaisyl gel is registered and used worldwide, we present the first case of contact photoallergy to isothipendyl chlorhydrate to our k
PMID 22677929

Extractive spectrophotometric determination of fluoroquinolones and antiallergic drugs in pure and pharmaceutical formulations.

Gowda BG, Seetharamappa J.SourceDepartment of Chemistry, Karnatak University, Dharwad-580 003, India.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.Anal Sci.2003 Mar;19(3):461-4.
A simple, rapid and sensitive spectrophotometric procedure has been proposed for the assay of fluoroquinolones viz., ciprofloxacin (CPF) and norfloxacin (NRF), and antiallergic drugs viz., methdilazine hydrochloride (MDH) and isothipendyl hydrochloride (IPH) in bulk and pharmaceutical formulations.
PMID 12675360

Spectrophotometric studies on the investigation of chromium in environmental samples.

Melwanki MB, Seetharamappa J.SourceDepartment of Chemistry, Karnatak University, Dharwad 580 003, India.
Indian journal of environmental health.Indian J Environ Health.2003 Jan;45(1):25-8.
Isothipendyl hydrochloride is proposed as a sensitive and selective reagent for the rapid spectrophotometric determination of chromium(VI). The reagent instantaneously gives a red coloured species on reaction with chromium(VI) in phosphoric acid medium which exhibits maximum absorbance at 510 nm wit
PMID 14723280

Japanese Journal

Extractive Spectrophotometric Determination of Fluoroquinolones and Antiallergic Drugs in Pure and Pharmaceutical Formulations.

Analytical Sciences 19(3), 461-464, 2003
NAID 130004440725

Spectrophotometric Determination of Molybdenum (VI) Using Isothipendyl Hydrochloride and Pipazethate Hydrochloride in Alloy Steels and Soil Samples

Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 17(9), 1121-1123, 2001-09-10
NAID 10007177968

O/W型クリーム中のイソチペンジルの分布とその放出性

藥學雜誌 105(2), 166-170, 1985-02-25
NAID 110003649592

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Isothipendyl
Systematic (IUPAC) name
	N,N-dimethyl-1-(10H-pyrido[3,2-b][1,4]benzothiazin-10-yl)propan-2-amine
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	482-15-5 1225-65-6
ATC code	D04AA22 R06AD09
PubChem	CID 3781
DrugBank	DB08802
ChemSpider	3649
UNII	WVZ7K9P0JY
KEGG	D08091
Chemical data
Formula	C16H19N3S
Mol. mass	285.408 g/mol
	SMILES n2c1N(c3c(Sc1ccc2)cccc3)CC(N(C)C)C;
	InChI InChI=1S/C16H19N3S/c1-12(18(2)3)11-19-13-7-4-5-8-14(13)20-15-9-6-10-17-16(15)19/h4-10,12H,11H2,1-3H3 ; Key:OQJBSDFFQWMKBQ-UHFFFAOYSA-N ;
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