ミリスチン酸イソプロピル

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/02/27 22:28:14」(JST)

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Isopropyl myristate is the ester of isopropanol and myristic acid.

Uses

Isopropyl myristate is used in cosmetic and topical medicinal preparations where good absorption through the skin is desired. It is also used as a pesticide-free treatment against head lice which works by dissolving the wax that covers the exoskeleton of head lice, killing them by dehydration.^[2]

It is used as a solvent in perfume materials.

It is the non-aqueous component of the two-phase mouthwash, Dentyl pH, where it removes bacteria from the oral cavity.

It is also used in the removal process of prosthetic make-up.

It is also used in flea and tick products for pets.

References

^ MSDS for isopropyl myristate
^ Anti-Lice Treatments

External links

Record in the Household Products Database of NLM

UpToDate Contents

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English Journal

Development of innovative oil-core self-organized nanovesicles prepared with chitosan and lecithin using a 2(3) full-factorial design.

Haas SE1, de Andrade C, Sansone PE, Guterres S, Dalla Costa T.Author information 1Programa de Pós-graduação em Ciências Farmacêuticas, UNIPAMPA, Universidade Federal do Pampa , Uruguaiana -- RS , Brazil and.AbstractThe aim of this study was to develop innovative nanosystems with isopropyl myristate as the oil core of self-assembly nanovesicles constituted of chitosan and lecithin using a 2(3) factorial design. The factors analyzed were chitosan (X1, levels 4 and 8 mg/ml), oil (X2, levels 10 and 20 mg/ml) and lecithin (X3, levels 4 and 8 mg/ml). The responses evaluated were diameter, zeta potential, pH, viscosity, and backscattering analysis. The bioavailability was evaluated after oral administration of clozapine free and nanoencapsulated in rats. The diameter ranged from 0.348 to 1.5 µm for F2 (X1, 4; X2, 10; X3, 8 mg/ml) and F7 (X1, 8; X2, 20; X3, 4 mg/ml), respectively. Laser diffractometry analysis revealed only one diameter population for all batches. Zeta potential was positive, being influenced by X1 and X2/X3 association. Viscosity values were dependent on the X1 and X2 concentrations used. A structure proposed for the nanosystem consists of chitosan forming the hydrophilic shell layer that protects the core comprised of lecithin and the hydrophobic groups of oil. The AUC0-∞ was almost 3 times higher with the clozapine nanoencapsuted in relation to free drug. It was developed a new nanosystem which is able of improving the absorption of drugs.
Pharmaceutical development and technology.Pharm Dev Technol.2014 Nov;19(7):769-78. doi: 10.3109/10837450.2013.829094. Epub 2013 Sep 2.
The aim of this study was to develop innovative nanosystems with isopropyl myristate as the oil core of self-assembly nanovesicles constituted of chitosan and lecithin using a 2(3) factorial design. The factors analyzed were chitosan (X1, levels 4 and 8 mg/ml), oil (X2, levels 10 and 20 mg/ml)
PMID 23998248

Development and evaluation of a tacrolimus cream formulation using a binary solvent system.

Yamanaka M1, Yokota S2, Iwao Y3, Noguchi S3, Itai S4.Author information 1Astellas Pharma Inc., Project & Product Management, 180 Ozumi, Yaizu, Shizuoka 425-0072, Japan; Department of Pharmaceutical Engineering, Graduate School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan.2Astellas Pharma Inc., Project & Product Management, 180 Ozumi, Yaizu, Shizuoka 425-0072, Japan.3Department of Pharmaceutical Engineering, Graduate School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan.4Department of Pharmaceutical Engineering, Graduate School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan. Electronic address: s-itai@u-shizuoka-ken.ac.jp.AbstractWe developed an oil/water-type tacrolimus (FK506) cream formulation as an alternative to Protopic ointment for atopic dermatitis treatment. We determined the effects of solvents used in topical preparations on FK506 solubility and stability, and evaluated FK506 transdermal absorption into rat skin from solutions, emulsions, and creams. Screening indicated that diethyl sebacate (DES), isopropyl myristate (IPM), propylene glycol (PG), and oleyl alcohol (OA) were adequate FK506 solvents. When FK506 solutions prepared using these solvents were transdermally administered, AUC0-24 values for DES and IPM were higher than or similar to that for 0.1% Protopic ointment. The AUC0-24 values for PG and OA were low, so these solvents did not enhance absorption. The residual ratios of FK506 in DES and IPM solutions after incubation at 70°C for 9d were 95.6% and 88.6%, respectively, so DES and IPM were chosen for emulsion preparation. When the emulsions were transdermally administered, the IPM emulsion AUC0-24 values increased 4.6-fold; DES emulsions did not show high transdermal absorption, but showed sustained characteristics. A cream formulation prepared by mixture of IPM and DES also showed high absorption and transdermal absorption increased with increasing IPM ratio. We developed an FK506 cream formulation with a controllable transdermal absorption rate by manipulating the IPM:DES ratio.
International journal of pharmaceutics.Int J Pharm.2014 Apr 10;464(1-2):19-26. doi: 10.1016/j.ijpharm.2014.01.017. Epub 2014 Jan 20.
We developed an oil/water-type tacrolimus (FK506) cream formulation as an alternative to Protopic ointment for atopic dermatitis treatment. We determined the effects of solvents used in topical preparations on FK506 solubility and stability, and evaluated FK506 transdermal absorption into rat skin f
PMID 24456671

FA-loaded lipid drug delivery systems: preparation, characterization and biological studies.

Carbone C, Campisi A, Musumeci T, Raciti G, Bonfanti R, Puglisi G.AbstractThe main purpose of this research was to prepare and to characterize ferulic acid-loaded nanostructured lipid carrier (FA-NLC) to evaluate the cytotoxic effect on human glioblastoma cancer U87MG cells. First of all, the influence of different materials on mean size and homogeneity of NLC prepared by a low energy organic solvent-free method was investigated. Technological characterization (encapsulation efficiency, mean particle size, homogeneity and in vitro release profile) was performed on the selected NLC in comparison to others lipid carriers, nanoemulsion and SLN. Furthermore, the thermal behavior of NLC and SLN was investigated using Differential Scanning Calorimetry (DSC) in order to evaluate their structure. Biological studies (MTT bioassay and caspase-3 cleavage) on the selected NLC showed no cytotoxic effects of the unloaded tested NLC. Besides, the effectiveness of FA-loaded NLC was higher compared to the free drug. Cells treated with FA or FA-loaded NLC showed a greater effect compared to idebenone (IDE) or IDE-loaded NLC, respectively. These results strongly support that FA-loaded NLC could be potentially used for the treatment of glioblastoma.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.Eur J Pharm Sci.2014 Feb 14;52:12-20.
The main purpose of this research was to prepare and to characterize ferulic acid-loaded nanostructured lipid carrier (FA-NLC) to evaluate the cytotoxic effect on human glioblastoma cancer U87MG cells. First of all, the influence of different materials on mean size and homogeneity of NLC prepared by
PMID 24514450

Japanese Journal

The Effect of Submicron Emulsion Systems on Transdermal Delivery of Kaempferol

Chao Yun,Huang Chi-Te,Fu Li-Tse,Huang Yaw-Bin,Tsai Yi-Hung,Wu Pao-Chu
Chemical and Pharmaceutical Bulletin 60(9), 1171-1175, 2012
… Kaempferol dispensed in isopropyl myristate was used as the control. …
NAID 130001852538

Preparation and Evaluation of Topical Microemulsion System Containing Metronidazole for Remission in Rosacea

Tirnaksiz Figen,Kayiş Ayşegül,Çelebi Nevin,Adişen Esra,Erel Arzu
Chemical and Pharmaceutical Bulletin 60(5), 583-592, 2012
… A pseudo-ternary phase diagram (Km=2 : 1) was constructed using lecithin/butanol/isopropyl myristate/water. …
NAID 130001852454

Efficient Topical Delivery of Chlorogenic Acid by an Oil-in-Water Microemulsion to Protect Skin against UV-Induced Damage

Kitagawa Shuji,Yoshii Kenta,Morita Shin-ya,Teraoka Reiko
Chemical and Pharmaceutical Bulletin 59(6), 793-796, 2011
… Using microemulsions consisting of 150 mM NaCl solution, isopropyl myristate, polyoxyethylene sorbitan monooleate (Tween 80) and ethanol, skin accumulation as well as solubility of chlorogenic acid further increased. …
NAID 130000748011

「myristate」

Isopropyl myristate^[1]
Names
	IUPAC name Propan-2-yl tetradecanoate
	Other names Tetradecanoic acid, 1-methylethyl ester; Myristic acid isopropyl ester
Identifiers
CAS number	110-27-0
ChemSpider	7751
EC number	203-751-4
	InChI InChI=1S/C17H34O2/c1-4-5-6-7-8-9-10-11-12-13-14-15-17(18)19-16(2)3/h16H,4-15H2,1-3H3 ; Key: AXISYYRBXTVTFY-UHFFFAOYSA-N ; InChI=1/C17H34O2/c1-4-5-6-7-8-9-10-11-12-13-14-15-17(18)19-16(2)3/h16H,4-15H2,1-3H3; Key: AXISYYRBXTVTFY-UHFFFAOYAN ;
Jmol-3D images	Image
KEGG	D02296
MeSH	C008205
PubChem	8042
RTECS number	XB8600000
	SMILES CCCCCCCCCCCCCC(=O)OC(C)C ;
Properties
Molecular formula	C17H34O2
Molar mass	270.45 g·mol−1
Density	0.85 g/cm³
Boiling point	167 °C (333 °F; 440 K) at 9 mmHg
Hazards
R-phrases	R38
S-phrases	S24/25
NFPA 704	1 2 0
	Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
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	Infobox references